ID   TOM40_CAEBR             Reviewed;         301 AA.
AC   Q61Z83; A8WSI3;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40 homolog;
DE   AltName: Full=Translocase of outer membrane 40 kDa subunit homolog;
GN   Name=tomm-40 {ECO:0000312|WormBase:CBG03225};
GN   ORFNames=CBG03225 {ECO:0000312|WormBase:CBG03225};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Channel-forming protein essential for import of protein
CC       precursors into mitochondria. Specifically required for nnt-1
CC       accumulation in the mitochondria and may be involved in the secretion
CC       of daf-28/insulin from the mitochondria. Required for embryonic and
CC       larval development. {ECO:0000250|UniProtKB:Q18090}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC       mitochondrial membrane (TOM complex). Interacts with mitochondrial
CC       targeting sequences. {ECO:0000250|UniProtKB:O96008}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q18090}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q18090}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
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DR   EMBL; HE601438; CAP23442.3; -; Genomic_DNA.
DR   RefSeq; XP_002631383.1; XM_002631337.1.
DR   AlphaFoldDB; Q61Z83; -.
DR   SMR; Q61Z83; -.
DR   STRING; 6238.CBG03225; -.
DR   PRIDE; Q61Z83; -.
DR   EnsemblMetazoa; CBG03225.1; CBG03225.1; WBGene00026127.
DR   GeneID; 8573382; -.
DR   KEGG; cbr:CBG_03225; -.
DR   CTD; 8573382; -.
DR   WormBase; CBG03225; CBP14675; WBGene00026127; Cbr-tomm-40.
DR   eggNOG; KOG3296; Eukaryota.
DR   HOGENOM; CLU_054399_0_0_1; -.
DR   InParanoid; Q61Z83; -.
DR   OMA; SHQFAMG; -.
DR   OrthoDB; 1346842at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   3: Inferred from homology;
KW   Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Porin; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   CHAIN           1..301
FT                   /note="Mitochondrial import receptor subunit TOM40 homolog"
FT                   /id="PRO_0000051528"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  32417 MW;  BCE3D5B8F7EAC1D9 CRC64;
     MATPTESEFA APIPQTNPGS YEELHRKARD VFPTCFEGAK LMVNKGLSSH FQVSHTLSLS
     AMNTGYRFGA TYVGTNQVGP AEAYPILLGD TDVNGNTTAT ILHQMGIYRT KLQGQIQQGK
     LAGAQATIER KGRLSTLGLT LANIDLVNEA GILVGQFLRR LTPRLDVGTE MVYQYGKNIP
     GGQISVLSYA ARYTANHFIA AATLGASGVH LTYYHKQHDN LAFGVEFECN ANVGEAVTTL
     AYQTELPEEG VTMRASFDTN WSVGGVFEKR LSQQLPFTLA LSGTLNHVKA AGKFGIGLII
     G