ID   BTG3_RAT                Reviewed;         252 AA.
AC   O88677;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Protein BTG3;
DE            Short=rBTG3;
DE   AltName: Full=BTG family member 3;
GN   Name=Btg3 {ECO:0000312|RGD:2226};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAC34894.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Fischer {ECO:0000312|EMBL:AAC34894.1};
RC   TISSUE=Fibroblast {ECO:0000269|PubMed:10564823};
RX   PubMed=10564823; DOI=10.1016/s0378-1119(99)00415-1;
RA   Seo M.S., Lee M.S., Lim I.K.;
RT   "Expression of rat BTG3 gene, Rbtg3, is regulated by redox changes.";
RL   Gene 240:165-173(1999).
CC   -!- FUNCTION: Overexpression impairs serum-induced cell cycle progression
CC       from the G0/G1 to S phase. {ECO:0000250|UniProtKB:P50615}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the brain.
CC       {ECO:0000269|PubMed:10564823}.
CC   -!- INDUCTION: By 12-O-tetradecanoylphorbol-13-acetate (TPA). Induced at
CC       higher levels by TPA and cycloheximide together. Also induced by redox
CC       changes after stimulation by hydrogen peroxide or menadione.
CC       {ECO:0000269|PubMed:10564823}.
CC   -!- SIMILARITY: Belongs to the BTG family. {ECO:0000255}.
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DR   EMBL; AF087037; AAC34894.1; -; mRNA.
DR   RefSeq; NP_062163.1; NM_019290.1.
DR   AlphaFoldDB; O88677; -.
DR   SMR; O88677; -.
DR   STRING; 10116.ENSRNOP00000002121; -.
DR   iPTMnet; O88677; -.
DR   PhosphoSitePlus; O88677; -.
DR   PaxDb; O88677; -.
DR   GeneID; 54230; -.
DR   KEGG; rno:54230; -.
DR   UCSC; RGD:2226; rat.
DR   CTD; 10950; -.
DR   RGD; 2226; Btg3.
DR   eggNOG; KOG4006; Eukaryota.
DR   InParanoid; O88677; -.
DR   OrthoDB; 1455216at2759; -.
DR   PhylomeDB; O88677; -.
DR   PRO; PR:O88677; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0006979; P:response to oxidative stress; IEP:RGD.
DR   Gene3D; 3.90.640.90; -; 1.
DR   InterPro; IPR002087; Anti_prolifrtn.
DR   InterPro; IPR033332; BTG.
DR   InterPro; IPR036054; BTG-like_sf.
DR   PANTHER; PTHR22978; PTHR22978; 1.
DR   Pfam; PF07742; BTG; 1.
DR   PRINTS; PR00310; ANTIPRLFBTG1.
DR   SMART; SM00099; btg1; 1.
DR   SUPFAM; SSF160696; SSF160696; 1.
DR   PROSITE; PS00960; BTG_1; 1.
DR   PROSITE; PS01203; BTG_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..252
FT                   /note="Protein BTG3"
FT                   /id="PRO_0000143809"
FT   REGION          138..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  28914 MW;  D66C22A659F9A3FB CRC64;
     MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK PSKGQAYRCI
     RVNKFQRVDP DVLKACEDSC ILYSDLGLPK ELTLWVDPCE VCCRYGKKNN AFIVASFENE
     DENKDEISKK VSRALDKVTS DYHSGSSSSD EDTSKEVEVK PSAVATTPSP VYQISELIFP
     PLPMWHPLPR KKPGMYRGGG HQSHYPPPVP FAYPSPGRKN KAFRPIPVTW VPPPGMHCDR
     NHWINPHMLA PH