BTG3_HUMAN
ID BTG3_HUMAN Reviewed; 252 AA.
AC Q14201; D3DSC4; Q53XV1; Q96ET7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2002, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Protein BTG3;
DE AltName: Full=Abundant in neuroepithelium area protein;
DE AltName: Full=BTG family member 3;
DE AltName: Full=Protein Tob5;
GN Name=BTG3; Synonyms=ANA, TOB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9632145; DOI=10.1038/sj.onc.1201805;
RA Yoshida Y., Matsuda S., Ikematsu N., Kawamura-Tsuzuku J., Inazawa J.,
RA Umemori H., Yamamoto T.;
RT "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular
RT zone of the developing central nervous system.";
RL Oncogene 16:2687-2693(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=9067576; DOI=10.1038/sj.leu.2400599;
RA Guehenneux F., Duret L., Callanan M.B., Bouhas R., Hayette S., Berthet C.,
RA Samarut C., Rimokh R., Birot A.-M., Wang Q., Magaud J.-P., Rouault J.-P.;
RT "Cloning of the mouse BTG3 gene and definition of a new gene family (the
RT BTG family) involved in the negative control of the cell cycle.";
RL Leukemia 11:370-375(1997).
CC -!- FUNCTION: Overexpression impairs serum-induced cell cycle progression
CC from the G0/G1 to S phase.
CC -!- INTERACTION:
CC Q14201; Q01094: E2F1; NbExp=3; IntAct=EBI-948192, EBI-448924;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14201-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14201-2; Sequence=VSP_000578;
CC -!- TISSUE SPECIFICITY: Ubiquitous. High expression in the ventricular zone
CC of the developing central nervous system. High in ovary, testis,
CC prostate, thymus and lung. {ECO:0000269|PubMed:9067576}.
CC -!- DEVELOPMENTAL STAGE: Expression is cell cycle dependent with the
CC highest levels at the end of G1 phase, peaking at the G1-S transition.
CC {ECO:0000269|PubMed:9067576}.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
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DR EMBL; D64110; BAA33788.1; -; mRNA.
DR EMBL; BT007276; AAP35940.1; -; mRNA.
DR EMBL; CH471079; EAX10026.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX10029.1; -; Genomic_DNA.
DR EMBL; BC011957; AAH11957.1; -; mRNA.
DR CCDS; CCDS13569.1; -. [Q14201-1]
DR CCDS; CCDS46636.1; -. [Q14201-2]
DR PIR; T09539; T09539.
DR RefSeq; NP_001124386.1; NM_001130914.1. [Q14201-2]
DR RefSeq; NP_006797.3; NM_006806.4. [Q14201-1]
DR RefSeq; XP_016883754.1; XM_017028265.1. [Q14201-1]
DR RefSeq; XP_016883755.1; XM_017028266.1. [Q14201-1]
DR AlphaFoldDB; Q14201; -.
DR SMR; Q14201; -.
DR BioGRID; 116150; 24.
DR IntAct; Q14201; 13.
DR MINT; Q14201; -.
DR iPTMnet; Q14201; -.
DR PhosphoSitePlus; Q14201; -.
DR BioMuta; BTG3; -.
DR DMDM; 23830904; -.
DR EPD; Q14201; -.
DR jPOST; Q14201; -.
DR MassIVE; Q14201; -.
DR MaxQB; Q14201; -.
DR PeptideAtlas; Q14201; -.
DR PRIDE; Q14201; -.
DR ProteomicsDB; 59920; -. [Q14201-1]
DR ProteomicsDB; 59921; -. [Q14201-2]
DR Antibodypedia; 5926; 133 antibodies from 24 providers.
DR DNASU; 10950; -.
DR Ensembl; ENST00000339775.10; ENSP00000344609.6; ENSG00000154640.15. [Q14201-2]
DR Ensembl; ENST00000348354.7; ENSP00000284879.8; ENSG00000154640.15. [Q14201-1]
DR GeneID; 10950; -.
DR KEGG; hsa:10950; -.
DR MANE-Select; ENST00000348354.7; ENSP00000284879.8; NM_006806.5; NP_006797.3.
DR UCSC; uc002ykl.4; human. [Q14201-1]
DR CTD; 10950; -.
DR DisGeNET; 10950; -.
DR GeneCards; BTG3; -.
DR HGNC; HGNC:1132; BTG3.
DR HPA; ENSG00000154640; Low tissue specificity.
DR MIM; 605674; gene.
DR neXtProt; NX_Q14201; -.
DR OpenTargets; ENSG00000154640; -.
DR PharmGKB; PA25452; -.
DR VEuPathDB; HostDB:ENSG00000154640; -.
DR GeneTree; ENSGT00950000182952; -.
DR HOGENOM; CLU_079660_3_0_1; -.
DR InParanoid; Q14201; -.
DR OMA; HYGYRPR; -.
DR OrthoDB; 1455216at2759; -.
DR PhylomeDB; Q14201; -.
DR TreeFam; TF105272; -.
DR PathwayCommons; Q14201; -.
DR SignaLink; Q14201; -.
DR BioGRID-ORCS; 10950; 9 hits in 1078 CRISPR screens.
DR ChiTaRS; BTG3; human.
DR GeneWiki; BTG3; -.
DR GenomeRNAi; 10950; -.
DR Pharos; Q14201; Tbio.
DR PRO; PR:Q14201; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q14201; protein.
DR Bgee; ENSG00000154640; Expressed in ventricular zone and 191 other tissues.
DR ExpressionAtlas; Q14201; baseline and differential.
DR Genevisible; Q14201; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:MGI.
DR Gene3D; 3.90.640.90; -; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR033332; BTG.
DR InterPro; IPR036054; BTG-like_sf.
DR PANTHER; PTHR22978; PTHR22978; 1.
DR Pfam; PF07742; BTG; 1.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; SSF160696; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..252
FT /note="Protein BTG3"
FT /id="PRO_0000143807"
FT REGION 138..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104
FT /note="R -> RRDGVSPCWPDCSQTPDLVIRPPWPPKALDYRREPLRPASSFLIM
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_000578"
FT CONFLICT 40
FT /note="E -> G (in Ref. 1; BAA33788)"
FT /evidence="ECO:0000305"
FT CONFLICT 45
FT /note="H -> P (in Ref. 1; BAA33788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 29116 MW; BEBE7E15709D2CC7 CRC64;
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTLILQE KYKNHWYPEK PSKGQAYRCI
RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE VCCRYGEKNN AFIVASFENK
DENKDEISRK VTRALDKVTS DYHSGSSSSD EETSKEMEVK PSSVTAAASP VYQISELIFP
PLPMWHPLPR KKPGMYRGNG HQNHYPPPVP FGYPNQGRKN KPYRPIPVTW VPPPGMHCDR
NHWINPHMLA PH
