TNR19_HUMAN
ID TNR19_HUMAN Reviewed; 423 AA.
AC Q9NS68; A8KA09; A8KA26; B1AM40; B1AM41; B4E2I6; Q9BXZ9; Q9BY00; Q9NZV2;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 19;
DE AltName: Full=TRADE;
DE AltName: Full=Toxicity and JNK inducer;
DE Flags: Precursor;
GN Name=TNFRSF19; Synonyms=TAJ, TROY; ORFNames=UNQ1888/PRO4333;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH TRAF1; TRAF2;
RP TRAF3 AND TRAF5.
RC TISSUE=Fetal spleen;
RX PubMed=10809768; DOI=10.1074/jbc.275.20.15336;
RA Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.;
RT "TAJ, a novel member of the tumor necrosis factor receptor family,
RT activates the c-Jun N-terminal kinase pathway and mediates caspase-
RT independent cell death.";
RL J. Biol. Chem. 275:15336-15342(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Glial tumor;
RX PubMed=10764796; DOI=10.1074/jbc.m002691200;
RA Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA Senba E., Kitamura T.;
RT "TROY, a newly identified member of the tumor necrosis factor receptor
RT superfamily, exhibits a homology with Edar and is expressed in embryonic
RT skin and hair follicles.";
RL J. Biol. Chem. 275:20742-20747(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS THR-31 AND
RP ILE-405.
RA Chaudhary D., Long A.J.;
RT "TRADE, a novel TNF receptor family member associated with death
RT signaling.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS VAL-159
RP AND ILE-405.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PROTEIN SEQUENCE OF 30-44.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [10]
RP INTERACTION WITH LINGO1.
RX PubMed=15694321; DOI=10.1016/j.neuron.2004.12.040;
RA Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C.,
RA He Z.;
RT "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in
RT mediating the inhibitory activity of myelin inhibitors.";
RL Neuron 45:345-351(2005).
CC -!- FUNCTION: Can mediate activation of JNK and NF-kappa-B. May promote
CC caspase-independent cell death.
CC -!- SUBUNIT: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with
CC LINGO1. {ECO:0000269|PubMed:10809768, ECO:0000269|PubMed:15694321}.
CC -!- INTERACTION:
CC Q9NS68; P52565: ARHGDIA; NbExp=3; IntAct=EBI-530381, EBI-712693;
CC Q9NS68; P30086: PEBP1; NbExp=4; IntAct=EBI-530381, EBI-716384;
CC Q9NS68; P35232: PHB; NbExp=3; IntAct=EBI-530381, EBI-354213;
CC Q9NS68-2; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-12089038, EBI-6166686;
CC Q9NS68-2; Q8N3F0: MTURN; NbExp=3; IntAct=EBI-12089038, EBI-11980301;
CC Q9NS68-2; O43765: SGTA; NbExp=3; IntAct=EBI-12089038, EBI-347996;
CC Q9NS68-2; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-12089038, EBI-744081;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=TAJ-alpha, TRADEalpha;
CC IsoId=Q9NS68-1; Sequence=Displayed;
CC Name=2; Synonyms=TRADEbeta;
CC IsoId=Q9NS68-2; Sequence=VSP_006512;
CC Name=3;
CC IsoId=Q9NS68-3; Sequence=VSP_044886, VSP_006512;
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate. Detected at lower
CC levels in thymus, spleen, testis, uterus, small intestine, colon and
CC peripheral blood leukocytes.
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DR EMBL; AF167555; AAF71828.1; -; mRNA.
DR EMBL; AB040434; BAB03269.1; -; mRNA.
DR EMBL; AF246998; AAK28395.1; -; mRNA.
DR EMBL; AF246999; AAK28396.1; -; mRNA.
DR EMBL; AY358888; AAQ89247.1; -; mRNA.
DR EMBL; AK292874; BAF85563.1; -; mRNA.
DR EMBL; AK292891; BAF85580.1; -; mRNA.
DR EMBL; AK304290; BAG65148.1; -; mRNA.
DR EMBL; AL161422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08326.1; -; Genomic_DNA.
DR EMBL; BC047321; AAH47321.1; -; mRNA.
DR CCDS; CCDS55893.1; -. [Q9NS68-3]
DR CCDS; CCDS9301.1; -. [Q9NS68-2]
DR CCDS; CCDS9302.1; -. [Q9NS68-1]
DR RefSeq; NP_001191387.1; NM_001204458.1. [Q9NS68-2]
DR RefSeq; NP_001191388.1; NM_001204459.1. [Q9NS68-3]
DR RefSeq; NP_061117.2; NM_018647.3. [Q9NS68-1]
DR RefSeq; NP_683760.1; NM_148957.3. [Q9NS68-2]
DR RefSeq; XP_005266502.1; XM_005266445.2. [Q9NS68-1]
DR RefSeq; XP_011533448.1; XM_011535146.1. [Q9NS68-1]
DR RefSeq; XP_016876140.1; XM_017020651.1. [Q9NS68-1]
DR AlphaFoldDB; Q9NS68; -.
DR BioGRID; 120684; 61.
DR CORUM; Q9NS68; -.
DR IntAct; Q9NS68; 48.
DR MINT; Q9NS68; -.
DR STRING; 9606.ENSP00000371693; -.
DR GlyGen; Q9NS68; 1 site.
DR iPTMnet; Q9NS68; -.
DR PhosphoSitePlus; Q9NS68; -.
DR BioMuta; TNFRSF19; -.
DR DMDM; 21264102; -.
DR jPOST; Q9NS68; -.
DR MassIVE; Q9NS68; -.
DR MaxQB; Q9NS68; -.
DR PaxDb; Q9NS68; -.
DR PeptideAtlas; Q9NS68; -.
DR PRIDE; Q9NS68; -.
DR ProteomicsDB; 82498; -. [Q9NS68-1]
DR ProteomicsDB; 82499; -. [Q9NS68-2]
DR Antibodypedia; 2432; 379 antibodies from 33 providers.
DR DNASU; 55504; -.
DR Ensembl; ENST00000248484.9; ENSP00000248484.4; ENSG00000127863.16. [Q9NS68-2]
DR Ensembl; ENST00000382258.8; ENSP00000371693.4; ENSG00000127863.16. [Q9NS68-1]
DR Ensembl; ENST00000382263.3; ENSP00000371698.3; ENSG00000127863.16. [Q9NS68-2]
DR Ensembl; ENST00000403372.6; ENSP00000385408.2; ENSG00000127863.16. [Q9NS68-3]
DR GeneID; 55504; -.
DR KEGG; hsa:55504; -.
DR MANE-Select; ENST00000248484.9; ENSP00000248484.4; NM_148957.4; NP_683760.1. [Q9NS68-2]
DR UCSC; uc001uot.4; human. [Q9NS68-1]
DR CTD; 55504; -.
DR DisGeNET; 55504; -.
DR GeneCards; TNFRSF19; -.
DR HGNC; HGNC:11915; TNFRSF19.
DR HPA; ENSG00000127863; Tissue enhanced (salivary gland, skin).
DR MIM; 606122; gene.
DR neXtProt; NX_Q9NS68; -.
DR OpenTargets; ENSG00000127863; -.
DR PharmGKB; PA36608; -.
DR VEuPathDB; HostDB:ENSG00000127863; -.
DR eggNOG; ENOG502QQHI; Eukaryota.
DR GeneTree; ENSGT00940000153259; -.
DR HOGENOM; CLU_050058_0_0_1; -.
DR InParanoid; Q9NS68; -.
DR OMA; SHSCAFH; -.
DR PhylomeDB; Q9NS68; -.
DR TreeFam; TF331385; -.
DR PathwayCommons; Q9NS68; -.
DR SignaLink; Q9NS68; -.
DR BioGRID-ORCS; 55504; 6 hits in 1065 CRISPR screens.
DR ChiTaRS; TNFRSF19; human.
DR GeneWiki; TNFRSF19; -.
DR GenomeRNAi; 55504; -.
DR Pharos; Q9NS68; Tbio.
DR PRO; PR:Q9NS68; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9NS68; protein.
DR Bgee; ENSG00000127863; Expressed in upper arm skin and 157 other tissues.
DR ExpressionAtlas; Q9NS68; baseline and differential.
DR Genevisible; Q9NS68; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; NAS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0007254; P:JNK cascade; NAS:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR CDD; cd13418; TNFRSF19; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022342; TNFR_19.
DR InterPro; IPR034047; TNFRSF19_N.
DR PANTHER; PTHR12120:SF1; PTHR12120:SF1; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01969; TNFACTORR19.
DR SMART; SM00208; TNFR; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 30..423
FT /note="Tumor necrosis factor receptor superfamily member
FT 19"
FT /id="PRO_0000034597"
FT TOPO_DOM 30..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 33..72
FT /note="TNFR-Cys 1"
FT REPEAT 74..114
FT /note="TNFR-Cys 2"
FT REPEAT 116..149
FT /note="TNFR-Cys 3"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..46
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 49..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 52..72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 75..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 92..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 95..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 117..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 138..149
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT VAR_SEQ 1..132
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044886"
FT VAR_SEQ 416..423
FT /note="VRQRLGSL -> EA (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334,
FT ECO:0000303|Ref.3"
FT /id="VSP_006512"
FT VARIANT 31
FT /note="S -> T (in dbSNP:rs9550987)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_024278"
FT VARIANT 159
FT /note="A -> V (in dbSNP:rs61756242)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_070812"
FT VARIANT 405
FT /note="V -> I (in dbSNP:rs3751362)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.3"
FT /id="VAR_024279"
FT CONFLICT 74
FT /note="T -> A (in Ref. 1; AAF71828)"
FT /evidence="ECO:0000305"
FT CONFLICT 215..216
FT /note="GS -> ET (in Ref. 1; AAF71828)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="F -> L (in Ref. 3; AAK28396)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="T -> A (in Ref. 3; AAK28396)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 423 AA; 46015 MW; B5891CEA9ED45361 CRC64;
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK
ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG
FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT
VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD
SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV
PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQVRQRL
GSL
