TNR17_MOUSE
ID TNR17_MOUSE Reviewed; 185 AA.
AC O88472;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 17;
DE AltName: Full=B-cell maturation protein;
DE AltName: CD_antigen=CD269;
GN Name=Tnfrsf17; Synonyms=Bcm, Bcma;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=BALB/cJ; TISSUE=Spleen;
RX PubMed=9846698; DOI=10.1093/intimm/10.11.1693;
RA Madry C., Laabi Y., Callebaut I., Roussel J., Hatzoglou A., Le Coniat M.,
RA Mornon J.-P., Berger R., Tsapis A.;
RT "The characterization of murine BCMA gene defines it as a new member of the
RT tumor necrosis factor receptor superfamily.";
RL Int. Immunol. 10:1693-1702(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes
CC B-cell survival and plays a role in the regulation of humoral immunity.
CC Activates NF-kappa-B and JNK (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O88472-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O88472-2; Sequence=VSP_006507;
CC -!- TISSUE SPECIFICITY: Detected in spleen, thymus, bone marrow and heart,
CC and at lower levels in kidney and lung.
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DR EMBL; AF061505; AAC23799.1; -; mRNA.
DR EMBL; AK020247; BAB32038.1; -; mRNA.
DR EMBL; BC027519; AAH27519.1; -; mRNA.
DR CCDS; CCDS27962.1; -. [O88472-1]
DR RefSeq; NP_035738.1; NM_011608.1. [O88472-1]
DR AlphaFoldDB; O88472; -.
DR SMR; O88472; -.
DR BioGRID; 204247; 1.
DR STRING; 10090.ENSMUSP00000023140; -.
DR ChEMBL; CHEMBL1250345; -.
DR PhosphoSitePlus; O88472; -.
DR PaxDb; O88472; -.
DR PRIDE; O88472; -.
DR Antibodypedia; 11568; 692 antibodies from 42 providers.
DR DNASU; 21935; -.
DR Ensembl; ENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496. [O88472-1]
DR GeneID; 21935; -.
DR KEGG; mmu:21935; -.
DR UCSC; uc007yfh.1; mouse. [O88472-1]
DR CTD; 608; -.
DR MGI; MGI:1343050; Tnfrsf17.
DR VEuPathDB; HostDB:ENSMUSG00000022496; -.
DR eggNOG; ENOG502SF2N; Eukaryota.
DR GeneTree; ENSGT00940000154485; -.
DR HOGENOM; CLU_131588_0_0_1; -.
DR InParanoid; O88472; -.
DR OMA; CHLRCSN; -.
DR OrthoDB; 1334921at2759; -.
DR PhylomeDB; O88472; -.
DR TreeFam; TF337842; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 21935; 1 hit in 73 CRISPR screens.
DR PRO; PR:O88472; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; O88472; protein.
DR Bgee; ENSMUSG00000022496; Expressed in kidney vasculature and 20 other tissues.
DR Genevisible; O88472; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002260; P:lymphocyte homeostasis; IMP:MGI.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd13414; TNFRSF17; 1.
DR InterPro; IPR015337; BCMA_Tall-1-bd.
DR InterPro; IPR043521; TNFR_13C/17.
DR InterPro; IPR022320; TNFR_17.
DR PANTHER; PTHR20437; PTHR20437; 1.
DR Pfam; PF09257; BCMA-Tall_bind; 1.
DR PIRSF; PIRSF011859; BCMA_Tall-1_bd; 1.
DR PRINTS; PR01967; TNFACTORR17.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Alternative splicing; Disulfide bond; Immunity;
KW Membrane; Receptor; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..185
FT /note="Tumor necrosis factor receptor superfamily member
FT 17"
FT /id="PRO_0000058936"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 4..36
FT /note="TNFR-Cys"
FT DISULFID 5..18
FT /evidence="ECO:0000250"
FT DISULFID 21..32
FT /evidence="ECO:0000250"
FT DISULFID 25..36
FT /evidence="ECO:0000250"
FT VAR_SEQ 87..91
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9846698"
FT /id="VSP_006507"
SQ SEQUENCE 185 AA; 20442 MW; 8806352B4FD26A8E CRC64;
MAQQCFHSEY FDSLLHACKP CHLRCSNPPA TCQPYCDPSV TSSVKGTYTV LWIFLGLTLV
LSLALFTISF LLRKMNPEAL KDEPQSPGQL DGSAQLDKAD TELTRIRAGD DRIFPRSLEY
TVEECTCEDC VKSKPKGDSD HFFPLPAMEE GATILVTTKT GDYGKSSVPT ALQSVMGMEK
PTHTR
