TNR12_MOUSE
ID TNR12_MOUSE Reviewed; 129 AA.
AC Q9CR75; Q3TVG8; Q9QZW3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 12A;
DE AltName: Full=Fibroblast growth factor-inducible immediate-early response protein 14;
DE Short=FGF-inducible 14;
DE AltName: Full=Fibroblast growth factor-regulated protein 2;
DE AltName: Full=Tweak-receptor;
DE Short=TweakR;
DE AltName: CD_antigen=CD266;
DE Flags: Precursor;
GN Name=Tnfrsf12a; Synonyms=Fgfrp2, Fn14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Fibroblast;
RX PubMed=10551889; DOI=10.1074/jbc.274.46.33166;
RA Meighan-Mantha R.L., Hsu D.K.W., Guo Y., Brown S.A.N., Feng S.-L.Y.,
RA Peifley K.A., Alberts G.F., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA Richards C.M., Winkles J.A.;
RT "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein
RT that modulates fibroblast adhesion and migration.";
RL J. Biol. Chem. 274:33166-33176(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of
CC apoptosis in some cell types. Promotes angiogenesis and the
CC proliferation of endothelial cells. May modulate cellular adhesion to
CC matrix proteins. {ECO:0000250}.
CC -!- SUBUNIT: Associates with TRAF1 and TRAF2, and probably also with TRAF3.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in fetal heart, intestine, kidney,
CC liver, lung and skin, and in adult heart and ovary. Intermediate
CC expression in adult kidney, lung and skin.
CC -!- INDUCTION: By FGF-1.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF156164; AAF07882.1; -; mRNA.
DR EMBL; AK005382; BAB23989.1; -; mRNA.
DR EMBL; AK005530; BAB24101.1; -; mRNA.
DR EMBL; AK160136; BAE35650.1; -; mRNA.
DR EMBL; BC025860; AAH25860.1; -; mRNA.
DR CCDS; CCDS28456.1; -.
DR RefSeq; NP_001155218.1; NM_001161746.1.
DR RefSeq; NP_038777.2; NM_013749.2.
DR AlphaFoldDB; Q9CR75; -.
DR SMR; Q9CR75; -.
DR BioGRID; 205159; 4.
DR STRING; 10090.ENSMUSP00000024698; -.
DR iPTMnet; Q9CR75; -.
DR PhosphoSitePlus; Q9CR75; -.
DR MaxQB; Q9CR75; -.
DR PaxDb; Q9CR75; -.
DR PeptideAtlas; Q9CR75; -.
DR PRIDE; Q9CR75; -.
DR ProteomicsDB; 259287; -.
DR DNASU; 27279; -.
DR Ensembl; ENSMUST00000024698; ENSMUSP00000024698; ENSMUSG00000023905.
DR GeneID; 27279; -.
DR KEGG; mmu:27279; -.
DR UCSC; uc008asv.2; mouse.
DR CTD; 51330; -.
DR MGI; MGI:1351484; Tnfrsf12a.
DR VEuPathDB; HostDB:ENSMUSG00000023905; -.
DR eggNOG; ENOG502SFZC; Eukaryota.
DR GeneTree; ENSGT00960000191910; -.
DR HOGENOM; CLU_164863_0_0_1; -.
DR InParanoid; Q9CR75; -.
DR OMA; HSDFCRG; -.
DR OrthoDB; 1502512at2759; -.
DR PhylomeDB; Q9CR75; -.
DR TreeFam; TF337901; -.
DR Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR BioGRID-ORCS; 27279; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Tnfrsf12a; mouse.
DR PRO; PR:Q9CR75; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CR75; protein.
DR Bgee; ENSMUSG00000023905; Expressed in interventricular septum and 203 other tissues.
DR ExpressionAtlas; Q9CR75; baseline and differential.
DR Genevisible; Q9CR75; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0001726; C:ruffle; IDA:MGI.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IDA:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0045773; P:positive regulation of axon extension; IDA:MGI.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0045765; P:regulation of angiogenesis; IDA:UniProtKB.
DR GO; GO:0061041; P:regulation of wound healing; ISO:MGI.
DR GO; GO:0006931; P:substrate-dependent cell migration, cell attachment to substrate; IDA:MGI.
DR CDD; cd13413; TNFRSF12A; 1.
DR InterPro; IPR022316; TNFR_12.
DR PANTHER; PTHR32037; PTHR32037; 1.
DR Pfam; PF12191; stn_TNFRSF12A; 1.
DR PRINTS; PR01962; TNFACTORR12.
PE 2: Evidence at transcript level;
KW Angiogenesis; Apoptosis; Cell adhesion; Developmental protein;
KW Differentiation; Disulfide bond; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..129
FT /note="Tumor necrosis factor receptor superfamily member
FT 12A"
FT /id="PRO_0000034612"
FT TOPO_DOM 28..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 36..67
FT /note="TNFR-Cys; atypical"
FT DISULFID 36..49
FT /evidence="ECO:0000250"
FT DISULFID 52..67
FT /evidence="ECO:0000250"
FT DISULFID 55..64
FT /evidence="ECO:0000250"
FT CONFLICT 3..4
FT /note="SA -> PG (in Ref. 1; AAF07882)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 129 AA; 13641 MW; 1665C68B4D9A9253 CRC64;
MASAWPRSLP QILVLGFGLV LMRAAAGEQA PGTSPCSSGS SWSADLDKCM DCASCPARPH
SDFCLGCAAA PPAHFRLLWP ILGGALSLVL VLALVSSFLV WRRCRRREKF TTPIEETGGE
GCPGVALIQ
