TNPO1_ORYSJ
ID TNPO1_ORYSJ Reviewed; 891 AA.
AC B9FDR3; Q0J8R4;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2013, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Transportin-1;
DE Short=OsTRN1;
DE AltName: Full=Importin beta-2;
DE AltName: Full=Karyopherin beta-2;
GN Name=TRN1; OrderedLocusNames=Os04g0691500, LOC_Os04g59494;
GN ORFNames=OsJ_16737;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 4-891.
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP GENE FAMILY.
RX PubMed=21556326; DOI=10.1371/journal.pone.0019308;
RA O'Reilly A.J., Dacks J.B., Field M.C.;
RT "Evolution of the karyopherin-? family of nucleocytoplasmic transport
RT factors; ancient origins and continued specialization.";
RL PLoS ONE 6:E19308-E19308(2011).
CC -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC receptor. Serves as receptor for nuclear localization signals (NLS) in
CC cargo substrates. Is thought to mediate docking of the
CC importin/substrate complex to the nuclear pore complex (NPC) through
CC binding to nucleoporin and the complex is subsequently translocated
CC through the pore by an energy requiring, Ran-dependent mechanism. At
CC the nucleoplasmic side of the NPC, Ran binds to the importin, the
CC importin/substrate complex dissociates and importin is re-exported from
CC the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The
CC directionality of nuclear import is thought to be conferred by an
CC asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC the cytoplasm and nucleus (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm
CC {ECO:0000250}. Note=Shuttles continuously between the nucleus and the
CC cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF16273.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE61964.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE61964.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP008210; BAF16273.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000141; EEE61964.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015636189.1; XM_015780703.1.
DR AlphaFoldDB; B9FDR3; -.
DR SMR; B9FDR3; -.
DR STRING; 4530.OS04T0691500-01; -.
DR iPTMnet; B9FDR3; -.
DR PaxDb; B9FDR3; -.
DR PRIDE; B9FDR3; -.
DR GeneID; 4337505; -.
DR KEGG; osa:4337505; -.
DR eggNOG; KOG2023; Eukaryota.
DR HOGENOM; CLU_008136_1_0_1; -.
DR InParanoid; B9FDR3; -.
DR OrthoDB; 525700at2759; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000007752; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR Genevisible; B9FDR3; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; PTHR10527; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..891
FT /note="Transportin-1"
FT /id="PRO_0000421802"
FT REPEAT 14..40
FT /note="HEAT 1"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT DOMAIN 35..103
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT REPEAT 45..83
FT /note="HEAT 2"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 92..125
FT /note="HEAT 3"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 131..168
FT /note="HEAT 4"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 178..208
FT /note="HEAT 5"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 221..248
FT /note="HEAT 6"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 260..287
FT /note="HEAT 7"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 303..381
FT /note="HEAT 8"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 389..420
FT /note="HEAT 9"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 432..459
FT /note="HEAT 10"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 477..510
FT /note="HEAT 11"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 518..551
FT /note="HEAT 12"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 559..597
FT /note="HEAT 13"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 605..653
FT /note="HEAT 14"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 664..695
FT /note="HEAT 15"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 703..740
FT /note="HEAT 16"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 748..784
FT /note="HEAT 17"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 792..825
FT /note="HEAT 18"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 834..866
FT /note="HEAT 19"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REGION 317..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 125
FT /note="V -> L (in Ref. 4; EEE61964)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 891 AA; 98661 MW; 49FB18C17CF3CB29 CRC64;
MAAAAALWQP QEEGLREICT LLDAHISPNS DQARIWQQLQ HYSQFPDFNN YLVFLLARGE
GKSFEARQAA GLLLKNNLRA TFSSMPPASQ QYVKSELLPC IGATNKAIRS TVGTVISVLF
QIVRVAGWIE LFQALHQCLD SNDLDHMEGA MDAIYKICED VPEELDVDVP GLPERPINVF
MPRLLQFFQS THAILRKLAL GCINQYIVVM PAALYMSMDQ YLQGLFNLAK DPSADVRKLV
CSAWVQLIEV RPSILEPHLK NVTELMLQAN KDSDDEVALE ACEFWSAYCD VSMPPEGLRE
FLPRLIPTLL SNMSYSDDDE SLADAEEDES FPDRDQDLKP RFHASRLHGS ETGEDDDDDD
AVNVWNLRKC SAAGLDVLSN VFGDDILPTL MPLIQQNLAR TDDDAWKERE AAVLSIGAIA
EGCITGLYPH LPQIVAFLIP LLDDKFPLIR SITCWTLSRY SKFIVQSLEH PNGREQFDKI
LLGLLRRVLD TNKRVQEAAC SAFATLEEEA AEELVPHLGI ILQHLMCAYG KYQRRNLRIL
YDALGTLADA VGAELNQAKY LDIFMPPLIT KWQQLANSDK DLFPLLECFT SIAQALGPGF
SQFAEPVFQR CINLIQSQHL AKVDPAAAGA LYDKEFIVCA LDLLSGLAEG LGAGIESLVS
QSSLRDILLQ CCMDEAADVR QSALALLGDL SRVCPIHLHP RLQEFLNVAA KQLNPQCVKE
AVSVANNACW AIGELAIKIG KEISPVVITV VSCLVPILKS PEGLNKSLLE NSAITLGRLC
WVCPDIVAPH MDHFMQAWCN ALCMIRDDFE KEDAFHGLCA MVAANPTGAV GSLTFICQAC
ASWNEIKSEG LHNEVCQILN GYKQMLGSGG WEQCMSTLEP AVVQRLGRYG V
