TNPO1_ORYSI
ID TNPO1_ORYSI Reviewed; 890 AA.
AC B8ARW2; Q8H0P3;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Transportin-1;
DE Short=OsTRN1;
DE AltName: Full=Importin beta-2;
DE AltName: Full=Karyopherin beta-2;
GN ORFNames=OsI_18044;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 512-890.
RC STRAIN=cv. IR36; TISSUE=Etiolated shoot;
RX PubMed=14756317; DOI=10.1023/b:plan.0000009288.46713.1f;
RA Ziemienowicz A., Haasen D., Staiger D., Merkle T.;
RT "Arabidopsis transportin1 is the nuclear import receptor for the circadian
RT clock-regulated RNA-binding protein AtGRP7.";
RL Plant Mol. Biol. 53:201-212(2003).
CC -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC receptor. Serves as receptor for nuclear localization signals (NLS) in
CC cargo substrates. Is thought to mediate docking of the
CC importin/substrate complex to the nuclear pore complex (NPC) through
CC binding to nucleoporin and the complex is subsequently translocated
CC through the pore by an energy requiring, Ran-dependent mechanism. At
CC the nucleoplasmic side of the NPC, Ran binds to the importin, the
CC importin/substrate complex dissociates and importin is re-exported from
CC the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The
CC directionality of nuclear import is thought to be conferred by an
CC asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC the cytoplasm and nucleus (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm
CC {ECO:0000250}. Note=Shuttles continuously between the nucleus and the
CC cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC80069.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CM000129; EEC78312.1; -; Genomic_DNA.
DR EMBL; Y18343; CAC80069.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; B8ARW2; -.
DR SMR; B8ARW2; -.
DR STRING; 39946.B8ARW2; -.
DR EnsemblPlants; BGIOSGA017411-TA; BGIOSGA017411-PA; BGIOSGA017411.
DR Gramene; BGIOSGA017411-TA; BGIOSGA017411-PA; BGIOSGA017411.
DR HOGENOM; CLU_008136_1_0_1; -.
DR OMA; MFPLLEC; -.
DR Proteomes; UP000007015; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; PTHR10527; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..890
FT /note="Transportin-1"
FT /id="PRO_0000421801"
FT REPEAT 13..39
FT /note="HEAT 1"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT DOMAIN 34..102
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT REPEAT 44..82
FT /note="HEAT 2"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 91..124
FT /note="HEAT 3"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 130..167
FT /note="HEAT 4"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 177..207
FT /note="HEAT 5"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 220..247
FT /note="HEAT 6"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 259..286
FT /note="HEAT 7"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 302..380
FT /note="HEAT 8"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 388..419
FT /note="HEAT 9"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 431..458
FT /note="HEAT 10"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 476..509
FT /note="HEAT 11"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 517..550
FT /note="HEAT 12"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 558..596
FT /note="HEAT 13"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 604..652
FT /note="HEAT 14"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 663..694
FT /note="HEAT 15"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 702..739
FT /note="HEAT 16"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 747..783
FT /note="HEAT 17"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 791..824
FT /note="HEAT 18"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REPEAT 833..865
FT /note="HEAT 19"
FT /evidence="ECO:0000250|UniProtKB:Q92973"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 620
FT /note="A -> P (in Ref. 2; CAC80069)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 890 AA; 98604 MW; 44CDC0D0AECA1F33 CRC64;
MAAAALWQPQ EEGLREICTL LDAHISPNSD QARIWQQLQH YSQFPDFNNY LVFLLARGEG
KSFEARQAAG LLLKNNLRAT FSSMPPASQQ YVKSELLPCI GATNKAIRST VGTVISVLFQ
IVRVAGWIEL FQALHQCLDS NDLDHMEGAM DAIYKICEDV PEELDVDVPG LPERPINVFM
PRLLQFFQST HAILRKLALG CINQYIVVMP AALYMSMDQY LQGLFNLAKD PSADVRKLVC
SAWVQLIEVR PSILEPHLKN VTELMLQANK DSDDEVALEA CEFWSAYCDV SMPPEGLREF
LPRLIPTLLS NMSYSDDDES LADAEEEESF PDRDQDLKPR FHASRLHGSE TGEDDDDDDA
VNVWNLRKCS AAGLDVLSNV FGDDILPTLM PLIQQNLART DDDAWKEREA AVLSIGAIAE
GCITGLYPHL PQIVAFLIPL LDDKFPLIRS ITCWTLSRYS KFIVQSLEHP NGREQFDKIL
LGLLRRVLDT NKRVQEAACS AFATLEEEAA EELVPHLGII LQHLMCAYGK YQRRNLRILY
DALGTLADAV GAELNQAKYL DIFMPPLITK WQQLANSDKD LFPLLECFTS IAQALGPGFS
QFAEPVFQRC INLIQSQHLA KVDPAAAGAL YDKEFIVCAL DLLSGLAEGL GAGIESLVSQ
SSLRDILLQC CMDEAADVRQ SALALLGDLS RVCPIHLHPR LQEFLNVAAK QLNPQCVKEA
VSVANNACWA IGELAIKIGK EISPVVITVV SCLVPILKSP EGLNKSLLEN SAITLGRLCW
VCPDIVAPHM DHFMQAWCNA LCMIRDDFEK EDAFHGLCAM VAANPTGAVG SLTFICQACA
SWNEIKSEGL HNEVCQILNG YKQMLGSGGW EQCMSTLEPA VVQRLGRYGV
