ID   TNPM_ECOLX              Reviewed;         116 AA.
AC   P04162;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1986, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Transposon Tn21 modulator protein;
GN   Name=tnpM;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn21;
RX   PubMed=2992807; DOI=10.1016/0092-8674(85)90120-5;
RA   Hyde D.R., Tu C.-P.T.;
RT   "tnpM: a novel regulatory gene that enhances Tn21 transposition and
RT   suppresses cointegrate resolution.";
RL   Cell 42:629-638(1985).
CC   -!- FUNCTION: This protein enhances the Tn21 transposition by activating
CC       expression of the transposase gene and decreases the resolution of the
CC       cointegrated DNA by suppressing expression of the resolvase gene.
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DR   EMBL; M10791; AAA27420.1; -; Genomic_DNA.
DR   PIR; A03567; RGECMD.
DR   RefSeq; WP_000454193.1; NZ_WVVT01000055.1.
DR   RefSeq; YP_001096415.1; NC_009133.1.
DR   RefSeq; YP_006952403.1; NC_019062.1.
DR   AlphaFoldDB; P04162; -.
DR   SMR; P04162; -.
DR   GeneID; 58464031; -.
DR   Gene3D; 3.20.20.450; -; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR021767; TnpM.
DR   Pfam; PF11809; DUF3330; 1.
DR   Pfam; PF00563; EAL; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
DR   PROSITE; PS50883; EAL; 1.
PE   4: Predicted;
KW   Activator; Repressor; Transcription; Transcription regulation;
KW   Transposable element.
FT   CHAIN           1..116
FT                   /note="Transposon Tn21 modulator protein"
FT                   /id="PRO_0000072609"
FT   DOMAIN          1..47
FT                   /note="EAL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00074"
SQ   SEQUENCE   116 AA;  12550 MW;  8CE67203952FE375 CRC64;
     MEVVAEGVET PDCLAWLRQA GCDTVQGFLF ARPMPAAAFV GFVNQWRNTT MNANEPSTSC
     CVCCKEIPLD AAFTPEGAEY VEHFCGLECY QRFQARASTA TETSVKPDAC DSPPSG