ID   TNPA_BACFR              Reviewed;         519 AA.
AC   Q64NF0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transposase for insertion sequence element IS21-like;
GN   Name=tnpA; OrderedLocusNames=BF4241;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the transposase IS21/IS408/IS1162 family.
CC       {ECO:0000305}.
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DR   EMBL; AP006841; BAD50983.1; -; Genomic_DNA.
DR   RefSeq; WP_011203618.1; NC_006347.1.
DR   RefSeq; YP_101517.1; NC_006347.1.
DR   AlphaFoldDB; Q64NF0; -.
DR   STRING; 295405.BF4241; -.
DR   PRIDE; Q64NF0; -.
DR   EnsemblBacteria; BAD50983; BAD50983; BF4241.
DR   KEGG; bfr:BF4241; -.
DR   PATRIC; fig|295405.11.peg.4091; -.
DR   HOGENOM; CLU_020626_1_4_10; -.
DR   OMA; CMRTENG; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR017894; HTH_IS21_transposase_type.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50531; HTH_IS21; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..519
FT                   /note="Transposase for insertion sequence element IS21-
FT                   like"
FT                   /id="PRO_0000075462"
FT   DOMAIN          13..78
FT                   /note="HTH IS21-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00615"
FT   DOMAIN          135..311
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   519 AA;  61367 MW;  5E996BFF6593CDF4 CRC64;
     MEIRKQYFKE KQYMWHKVRE LQLKGLNKTQ IGIYLGVNRK TVRRYLNMTM EEFVKKQSSH
     RKYRLKLENY EQYVRANLEE YPYISAARIH DWLKECYPDF PRVCNRTISG FVERVRKKYG
     IGKKVETHKR NYEKQPDTPY GEYAQADFGE KCMRTENGKS IKVYFFAIVL SRSRYKFIYF
     SRRPFDTGLA VYAHELAFEY FGGRPQKIIY DQDKVLIARA NMGDLILTGK FQAFVKEQHF
     HPVFCHKADP ESKGRVENVV KYVKTNFLTA RIFQNVDRLN EEARLWLERT GNGKEYGTTH
     RIPLEEFAQE REYLVPYHGT PHSPGGEMKE YHVRKDNTVQ YRGNYYSLPC GTYRGGETTV
     WLHETDGCLE LYNKETGKLV CRHDLCELKG KTIYGEGHRR QRNIGAQKLA ERILIYVSYN
     REVALWLENL QRRKERYYRE NLEVILRIIP GYDKAILTEA VSVCLDKGIY NGESVKSLCG
     HIWKKKMRES DVGKNPASRT QSTGLVKTYN EIFRNNGKV