ID   TNPA_BACFG              Reviewed;         520 AA.
AC   Q45119;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Transposase for insertion sequence element IS21-like;
GN   Name=tnpA;
OS   Bacteroides fragilis.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RBF-103;
RX   PubMed=7517394; DOI=10.1128/jb.176.14.4376-4384.1994;
RA   Rogers M.B., Bennett T.K., Payne C.M., Smith C.J.;
RT   "Insertional activation of cepA leads to high-level beta-lactamase
RT   expression in Bacteroides fragilis clinical isolates.";
RL   J. Bacteriol. 176:4376-4384(1994).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the transposase IS21/IS408/IS1162 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA21540.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U05888; AAA21540.1; ALT_INIT; Genomic_DNA.
DR   PIR; I40198; I40198.
DR   RefSeq; WP_032573900.1; NZ_WCIJ01000009.1.
DR   AlphaFoldDB; Q45119; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017894; HTH_IS21_transposase_type.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50531; HTH_IS21; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..520
FT                   /note="Transposase for insertion sequence element IS21-
FT                   like"
FT                   /id="PRO_0000075463"
FT   DOMAIN          13..78
FT                   /note="HTH IS21-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00615"
FT   DOMAIN          136..312
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   520 AA;  61690 MW;  168CC97503E05232 CRC64;
     METKSQNLKD KLYMWYKVRE LQSKGLNKTQ IGKYLGVDRS TVRRYLRTSR EELFRKQNSH
     REYELKLGKY EEYVRGTLEE YPYISAARMH DWLKECYPDF PRVCDKTVFN FVDRIRRKYG
     IGKKSEVRIR RDYEKLPETP YGEYAQADFG EKWIPVKNGG STKVYFFAIV LTRSRYKFIH
     FSRRPFDTEL AIYAHELAFQ YFGGRPEKII YDQDRVLIAR ENLGDLILTG KFQSFIKEQH
     FQPVFCRRSD PESKGKVENV VKYVKENFLV ARVLQDIPGL NEEARKWLER TGNGKVHGTT
     RLVPSEEFAV EKGYLKPYYG LPQPPQEQMK EYHVRKDNTV QYRGNYYSLP CGTYRSGQTR
     VWLQETEGYV ELYSKETGKI VARHPLCTRK GKTIYDERHR RPKSIGAQKL AERILVYVSG
     NREVALWMEN LKRKKERYYK DNLEVVLHMM PGYDKDILIE AVHICLDKGI YNGDSVKSLC
     EHVHRRRNKE TETDRTDSCP PRQTGLIQSY NEIFHGYDKT