ID   TNP3_ECOLX              Reviewed;        1015 AA.
AC   P03008;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transposase for transposon Tn3;
GN   Name=tnpA;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn3;
RX   PubMed=391406; DOI=10.1016/0092-8674(79)90228-9;
RA   Heffron F., McCarthy B.J., Ohtsubo H., Ohtsubo E.;
RT   "DNA sequence analysis of the transposon Tn3: three genes and three sites
RT   involved in transposition of Tn3.";
RL   Cell 18:1153-1163(1979).
CC   -!- FUNCTION: Required for transposition of transposon Tn3.
CC   -!- SIMILARITY: Belongs to the transposase 7 family. {ECO:0000305}.
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DR   EMBL; V00613; CAA23884.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A03538; TQECT.
DR   RefSeq; NP_943293.1; NC_005248.1.
DR   RefSeq; WP_011154510.1; NC_005248.1.
DR   AlphaFoldDB; P03008; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004803; F:transposase activity; IEA:InterPro.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR   InterPro; IPR025296; DUF4158.
DR   InterPro; IPR002513; Tn3_Tnp_DDE_dom.
DR   Pfam; PF01526; DDE_Tnp_Tn3; 1.
DR   Pfam; PF13700; DUF4158; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..1015
FT                   /note="Transposase for transposon Tn3"
FT                   /id="PRO_0000075427"
SQ   SEQUENCE   1015 AA;  114530 MW;  571A442203B5FACA CRC64;
     MLKKPSGREA DMPVDFLTTE QVESYGRFTG EPDELQLARY FHLDEADKEF IGKSRGDHNR
     LGIALQIGCV RFLGTFLTDM NHIPSGVRHF TARQLGIRDI TVLAEYGQRE NTRREHAALI
     RQHYQYREFA WPWTFRLTRL LYTRSWISNE RPGLLFDLAT GWLMQHRIIL PGATTLTRLI
     SEVREKATLR LWNKLALIPS AEQRSQLEML LGPTDCSRLS LLESLKKGPV TISGPAFNEA
     IERWKTLNDF GLHAENLSTL PAVRLKNLAR YAGMTSVFNI ARMSPQKRMA VLVAFVLAWE
     TLALDDALEV LDAMLAVIIR DARKIGQKKR LRSLKDLDKS ALALASACSY LLKEETPDES
     IRAEVFSYIP RQKLAEIITL VREIARPSDD NFHDEMVEQY GRVRRFLPHL LNTVKFSSAP
     AGVTTLNACD YLSREFSSRR QFFDDAPTEI ISQSWKRLVI NKEKHITRRG YTLCFLSKLQ
     DSLRRRDVYV TGSNRWGDPR ARLLQGADWQ ANRIKVYRSL GHPTDPQEAI KSLGHQLDSR
     YRQVAARLGE NEAVELDVSG PKPRLTISPL ASLDEPDSLK RLSKMISDLL PPVDLTELLL
     EINAHTGFAD EFFHASEASA RVDDLPVSIS AVLMAEACNI GLEPLIRSNV PALTRHRLNW
     TKANYLRAET ITSANARLVD FQATLPLAQI WGGGEVASAD GMRFVTPVRT INAGPNRKYF
     GNNRGITWYN FVSDQYSGFH GFHGIVIPGT LRDSIFVLEG LLEQETGLNP TEIMTDTAGA
     SDLVFGLFWL LGYQFSPRLA DAGASVFWRM DHDADYGVLN DIARGQSDPR KIVLQWDEMI
     RTAGSLKLGK VQASVLVRSL LKSERPSGLT QAIIEVGRIN KTLYLLNYID DEDYRRRILT
     QLNRGESRHA VARAICHGQK GEIRKRYTDG QEDQLGALGL VTNAVVLWNT IYMQAALDHL
     RAQGETLNDE DIARLSPLCH GHINMLGHYS FTLAELVTKG HLRPLKEASE AENVA