ID   TNP2_ECOLX              Reviewed;         988 AA.
AC   P06694;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Transposase for transposon Tn21;
GN   Name=tnpA;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3029727; DOI=10.1093/nar/15.4.1799;
RA   Ward E., Grinsted J.;
RT   "The nucleotide sequence of the tnpA gene of Tn21.";
RL   Nucleic Acids Res. 15:1799-1806(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
RX   PubMed=2992807; DOI=10.1016/0092-8674(85)90120-5;
RA   Hyde D.R., Tu C.-P.T.;
RT   "tnpM: a novel regulatory gene that enhances Tn21 transposition and
RT   suppresses cointegrate resolution.";
RL   Cell 42:629-638(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
RX   PubMed=6312271; DOI=10.1007/bf00334812;
RA   Diver W.P., Grinsted J., Fritzinger D.C., Brown N.L., Altenbuchner J.,
RA   Rogowsky P., Schmitt R.;
RT   "DNA sequences of and complementation by the tnpR genes of Tn21, Tn501 and
RT   Tn1721.";
RL   Mol. Gen. Genet. 191:189-193(1983).
CC   -!- FUNCTION: Required for transposition of transposon Tn21.
CC   -!- MISCELLANEOUS: Tn21 is a transposon encoding resistance to sulfonamide,
CC       streptomycin, and mercuric ion.
CC   -!- SIMILARITY: Belongs to the transposase 7 family. {ECO:0000305}.
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DR   EMBL; X04891; CAA28579.1; -; Genomic_DNA.
DR   EMBL; M10791; AAA27422.1; -; Genomic_DNA.
DR   EMBL; X01298; CAA25627.1; -; Genomic_DNA.
DR   PIR; A26673; TQEC21.
DR   AlphaFoldDB; P06694; -.
DR   SMR; P06694; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004803; F:transposase activity; IEA:InterPro.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR   InterPro; IPR025296; DUF4158.
DR   InterPro; IPR002513; Tn3_Tnp_DDE_dom.
DR   Pfam; PF01526; DDE_Tnp_Tn3; 1.
DR   Pfam; PF13700; DUF4158; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..988
FT                   /note="Transposase for transposon Tn21"
FT                   /id="PRO_0000075428"
FT   REGION          672..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   988 AA;  110824 MW;  E962E405B6FBE941 CRC64;
     MPRRSILSAA ERESLLALPD SKDDLIRHYT FNDTDLSIIR QRRGPANRLG FAVQLCYLRF
     PGVILGVDEL PFPPLLKPVA DQPKVGVESW NEYGQREQTR REHLSELQTV FGFRPFTMSH
     YRQAVQMLTE LAMQTDKGIV LASALIGHLR RQSVILPALN AVERASAEAI TRANRRIYDA
     LAEPLADAHR RRLDDLLKRR DNGKTTWLAW LRQSPAKPNS RHMLEHIERL KAWQALDLPT
     GIERLVHQNR LLKIAREGGQ MTPADLAKFE PQRRYATLVA LATEGMATVT DEIIDLHDRI
     LGKLFNAAKN KHQQQFQASG KAINAKVRLY GRIGQALIDA KQSGRDAFAA IEAVMSWDSF
     AESVTEAQKL AQPGGFGFLH RIGESYATLR RYAPEFLAVL KLRAAPAAKN VLDAIEVLRG
     MNTDNARKLP ADAPTGFIKP RWQKLVMTDA GIDRAYYELC ALSELKNSLR SGDIWVQGSR
     QFKDFEDYLV PPEKFTSLKQ SSELPLAVAT GCEQYLHERL TLLEAQLATV NRMAAANDLP
     DAIITESGLK ITPLDAAVPD TAQALIDQTA MVLPHVKITE LLLEVDEWTG FTRHFTHLKS
     GDLAKDKNLL LTTILADAIN LGLTKMAESC PGTTYAKLAW LQAWHTRDET YSTALAELVN
     AQFRHPFAGH WGDGTTSSSD EQNFRTASKA KSTGHINPKY GSSPGRTFYT HISDQYAPFH
     TKVVNVGLRD STYVLDDLLY HESDLRIEEH YTDTAGFTDH VFALMHLLGF RFAPRIRDLG
     DTKLYIPKGD AAYDALKPMI GGTLNIKHVR AHWDEILRLA TSIKQGTVTA SLMLRKLGSY
     PRQNGLAVAL RELGRVERTL FILDWLQGVE LRRRVHAGLN KGEARNALAR AVFFNRLGEI
     RDRSFEQQRY RASGLNLVTA AIVLWNTVYL ERAAHALRGN GHAVDDSLLQ YLSPLGWEHI
     NLTGDYLWRS SAKIGAGKFR PLRPLQPA