TNNT3_RABIT
ID TNNT3_RABIT Reviewed; 279 AA.
AC P02641; P19349; P19350;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Troponin T, fast skeletal muscle;
DE Short=TnTf;
DE AltName: Full=Fast skeletal muscle troponin T;
DE Short=fTnT;
GN Name=TNNT3;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP PROTEIN SEQUENCE OF 2-11; 18-44 AND 57-279.
RX PubMed=320204; DOI=10.1016/s0021-9258(19)75195-3;
RA Pearlstone J.R., Johnson P., Carpenter M.R., Smillie L.B.;
RT "Primary structure of rabbit skeletal muscle troponin-T. Sequence
RT determination of the NH2-terminal fragment CB3 and the complete sequence of
RT troponin-T.";
RL J. Biol. Chem. 252:983-989(1977).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, AND ALTERNATIVE SPLICING.
RC STRAIN=New Zealand white; TISSUE=Skeletal muscle;
RX PubMed=8344466; DOI=10.1006/dbio.1993.1208;
RA Briggs M.M., Schachat F.;
RT "Origin of fetal troponin T: developmentally regulated splicing of a new
RT exon in the fast troponin T gene.";
RL Dev. Biol. 158:503-509(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, AND ALTERNATIVE SPLICING.
RC STRAIN=New Zealand white; TISSUE=Skeletal muscle;
RX PubMed=2373251; DOI=10.1016/0012-1606(90)90075-t;
RA Briggs M.M., McGinnis H.D., Schachat F.;
RT "Transitions from fetal to fast troponin T isoforms are coordinated with
RT changes in tropomyosin and alpha-actinin isoforms in developing rabbit
RT skeletal muscle.";
RL Dev. Biol. 140:253-260(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, AND ALTERNATIVE SPLICING.
RC STRAIN=New Zealand white; TISSUE=Skeletal muscle;
RA Briggs M.M., Schachat F.;
RL Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PROTEIN SEQUENCE OF 2-44 AND 57-66, ACETYLATION AT SER-2, AND CLEAVAGE OF
RP INITIATOR METHIONINE.
RC STRAIN=New Zealand white; TISSUE=Skeletal muscle;
RX PubMed=2704041; DOI=10.1016/0022-2836(89)90538-x;
RA Briggs M.M., Schachat F.;
RT "N-terminal amino acid sequences of three functionally different troponin T
RT isoforms from rabbit fast skeletal muscle.";
RL J. Mol. Biol. 206:245-249(1989).
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=TnT1;
CC IsoId=P02641-1; Sequence=Displayed;
CC Name=TnT1F;
CC IsoId=P02641-2; Sequence=VSP_006656;
CC Name=TnT2;
CC IsoId=P02641-3; Sequence=VSP_006655;
CC Name=TnT2F;
CC IsoId=P02641-4; Sequence=VSP_006653, VSP_006656;
CC Name=TnT2FA;
CC IsoId=P02641-5; Sequence=VSP_006655, VSP_006656;
CC Name=TnT2.5F;
CC IsoId=P02641-6; Sequence=VSP_006653, VSP_006655, VSP_006656;
CC Name=TnT3;
CC IsoId=P02641-7; Sequence=VSP_006654;
CC Name=TnT3F;
CC IsoId=P02641-8; Sequence=VSP_006654, VSP_006656;
CC Name=TnT4F;
CC IsoId=P02641-9; Sequence=VSP_006653, VSP_006654, VSP_006656;
CC -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR EMBL; U04970; AAA16023.1; -; mRNA.
DR EMBL; U04971; AAA16024.1; -; mRNA.
DR EMBL; U04972; AAA16025.1; -; mRNA.
DR EMBL; U04973; AAA16026.1; -; mRNA.
DR EMBL; U04974; AAA16027.1; -; mRNA.
DR EMBL; U04975; AAA16028.1; -; mRNA.
DR EMBL; U04976; AAA16029.1; -; mRNA.
DR EMBL; U04977; AAA16030.1; -; mRNA.
DR EMBL; U04978; AAA16031.1; -; mRNA.
DR AlphaFoldDB; P02641; -.
DR BMRB; P02641; -.
DR SMR; P02641; -.
DR CORUM; P02641; -.
DR STRING; 9986.ENSOCUP00000001509; -.
DR iPTMnet; P02641; -.
DR eggNOG; KOG3634; Eukaryota.
DR InParanoid; P02641; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0006942; P:regulation of striated muscle contraction; IEA:InterPro.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR027708; Tnnt3.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; PTHR11521; 1.
DR PANTHER; PTHR11521:SF4; PTHR11521:SF4; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Muscle protein; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2704041,
FT ECO:0000269|PubMed:320204"
FT CHAIN 2..279
FT /note="Troponin T, fast skeletal muscle"
FT /id="PRO_0000186180"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|PubMed:2704041"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZ47"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT MOD_RES 229
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P09739"
FT VAR_SEQ 12..17
FT /note="Missing (in isoform TnT2F, isoform TnT2.5F and
FT isoform TnT4F)"
FT /evidence="ECO:0000305"
FT /id="VSP_006653"
FT VAR_SEQ 23..39
FT /note="Missing (in isoform TnT3, isoform TnT3F and isoform
FT TnT4F)"
FT /evidence="ECO:0000305"
FT /id="VSP_006654"
FT VAR_SEQ 33..39
FT /note="Missing (in isoform TnT2, isoform TnT2FA and isoform
FT TnT2.5F)"
FT /evidence="ECO:0000305"
FT /id="VSP_006655"
FT VAR_SEQ 45..56
FT /note="Missing (in isoform TnT1F, isoform TnT2F, isoform
FT TnT2FA, isoform TnT2.5F, isoform TnT3F and isoform TnT4F)"
FT /evidence="ECO:0000305"
FT /id="VSP_006656"
FT CONFLICT 20
FT /note="Q -> E (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 36..37
FT /note="VH -> HV (in Ref. 1; AA sequence and 5; AA
FT sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="Missing (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 279 AA; 33034 MW; 1CF35712F2EE5281 CRC64;
MSDEEVEHVE EQYEEEEEAQ EEAPSPAEVH EPAPEVHVPE EVHEDALEDM REEEEEEEKP
RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL VALKERIEKR
RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAEE DLKKKKALSS MGANYSSYLA
KADQKRGKKQ TAREMKKKIL AERRKPLNID HLSDEKLRDK AKELWDTLYQ LETDKFEFGE
KLKRQKYDIM NVRARVEMLA KFSKKAGTTA KGKVGGRWK
