ID   TNNT3_COTJA             Reviewed;         253 AA.
AC   P06398; P06397;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 4.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Troponin T, fast skeletal muscle isoforms;
GN   Name=TNNT3;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2745456; DOI=10.1016/s0021-9258(18)63884-0;
RA   Bucher E.A., de la Brousse F.C., Emerson C.P. Jr.;
RT   "Developmental and muscle-specific regulation of avian fast skeletal
RT   troponin T isoform expression by mRNA splicing.";
RL   J. Biol. Chem. 264:12482-12491(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 109-253.
RX   PubMed=3840482; DOI=10.1016/s0021-9258(17)38782-3;
RA   Hastings K.E.M., Bucher E.A., Emerson C.P. Jr.;
RT   "Generation of troponin T isoforms by alternative RNA splicing in avian
RT   skeletal muscle. Conserved and divergent features in birds and mammals.";
RL   J. Biol. Chem. 260:13699-13703(1985).
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=P06398-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P06398-2; Sequence=VSP_006637;
CC       Name=3;
CC         IsoId=P06398-3; Sequence=VSP_006638;
CC   -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR   EMBL; M26600; AAA49506.1; -; mRNA.
DR   EMBL; M26599; AAA49505.1; -; mRNA.
DR   EMBL; M11685; AAA49504.1; -; mRNA.
DR   EMBL; M11684; AAA49503.1; -; mRNA.
DR   PIR; A03084; TPQJT1.
DR   PIR; A03085; TPQJT2.
DR   PIR; A34327; A34327.
DR   PIR; B34327; B34327.
DR   AlphaFoldDB; P06398; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR   GO; GO:0006942; P:regulation of striated muscle contraction; IEA:InterPro.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR027708; Tnnt3.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; PTHR11521; 1.
DR   PANTHER; PTHR11521:SF4; PTHR11521:SF4; 1.
DR   Pfam; PF00992; Troponin; 1.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Muscle protein; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..253
FT                   /note="Troponin T, fast skeletal muscle isoforms"
FT                   /id="PRO_0000186184"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         28..31
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_006637"
FT   VAR_SEQ         226..238
FT                   /note="LTLRCRLQELSKF -> VTLRNRIDQAQKH (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_006638"
SQ   SEQUENCE   253 AA;  30098 MW;  5E37D1A587FAC997 CRC64;
     MSDTEEVEHG EEEYEEEEEV QEEEVHEPAP PPEEKPRIKL TAPKIPEGEK VDFDDIQKKR
     QNKDLIELQA LIDSHFEARR KEEEELVALK ERIEKRRAER AEQQRIRAEK EKERQARLAE
     EKARREEEDA KRKAEDDLKK KKALSSMGAS YSSYLAKADQ KRGKKQTARE TKKKVLAERR
     KPLNIDHLNE DKLRDKAKEL WDWLYQLQTE KYDFTEQIKR KKYEILTLRC RLQELSKFSK
     KAGAKGKVGG RWK