TNNT3_CHICK
ID TNNT3_CHICK Reviewed; 263 AA.
AC P12620; P12618; P12619; P12621;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Troponin T, fast skeletal muscle isoforms;
GN Name=TNNT3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TNT-1; TNT-2; TNT-3 AND TNT-4).
RX PubMed=3198600; DOI=10.1016/s0021-9258(18)37355-1;
RA Smillie L.B., Golosinska K., Reinach F.C.;
RT "Sequences of complete cDNAs encoding four variants of chicken skeletal
RT muscle troponin T.";
RL J. Biol. Chem. 263:18816-18820(1988).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 58-112, X-RAY CRYSTALLOGRAPHY
RP (3.0 ANGSTROMS) OF 157-262, AND FUNCTION.
RX PubMed=15784741; DOI=10.1073/pnas.0408882102;
RA Vinogradova M.V., Stone D.B., Malanina G.G., Karatzaferi C., Cooke R.,
RA Mendelson R.A., Fletterick R.J.;
RT "Ca(2+)-regulated structural changes in troponin.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:5038-5043(2005).
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC {ECO:0000269|PubMed:15784741}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Comment=Additional isoforms seem to exist.;
CC Name=TNT-3;
CC IsoId=P12620-1; Sequence=Displayed;
CC Name=TNT-1;
CC IsoId=P12620-2; Sequence=VSP_006633;
CC Name=TNT-2;
CC IsoId=P12620-3; Sequence=VSP_006634, VSP_006636;
CC Name=TNT-4;
CC IsoId=P12620-4; Sequence=VSP_006634, VSP_006635;
CC -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR EMBL; M22156; AAA49102.1; -; mRNA.
DR EMBL; M22158; AAA49103.1; -; mRNA.
DR EMBL; M22155; AAA49101.1; -; mRNA.
DR EMBL; M22154; AAA49100.1; -; mRNA.
DR PIR; A31957; A31957.
DR PIR; B31957; B31957.
DR PIR; C31957; C31957.
DR PIR; D31957; D31957.
DR RefSeq; XP_015142056.1; XM_015286570.1. [P12620-1]
DR RefSeq; XP_015142059.1; XM_015286573.1. [P12620-3]
DR RefSeq; XP_015142062.1; XM_015286576.1. [P12620-4]
DR PDB; 1YTZ; X-ray; 3.00 A; T=157-263.
DR PDB; 1YV0; X-ray; 7.00 A; T=157-263.
DR PDB; 2W49; EM; 35.00 A; 1/4/7/Y=160-249.
DR PDB; 2W4U; EM; 35.00 A; 1/4/7/Y=160-249.
DR PDB; 2Z5H; X-ray; 2.89 A; T=58-112.
DR PDBsum; 1YTZ; -.
DR PDBsum; 1YV0; -.
DR PDBsum; 2W49; -.
DR PDBsum; 2W4U; -.
DR PDBsum; 2Z5H; -.
DR AlphaFoldDB; P12620; -.
DR SMR; P12620; -.
DR IntAct; P12620; 2.
DR MINT; P12620; -.
DR STRING; 9031.ENSGALP00000010605; -.
DR GeneID; 395761; -.
DR CTD; 7140; -.
DR VEuPathDB; HostDB:geneid_395761; -.
DR eggNOG; KOG3634; Eukaryota.
DR HOGENOM; CLU_076377_2_0_1; -.
DR InParanoid; P12620; -.
DR OrthoDB; 1480247at2759; -.
DR EvolutionaryTrace; P12620; -.
DR PRO; PR:P12620; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR GO; GO:0030172; F:troponin C binding; IBA:GO_Central.
DR GO; GO:0031013; F:troponin I binding; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0006942; P:regulation of striated muscle contraction; IEA:InterPro.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR027708; Tnnt3.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; PTHR11521; 1.
DR PANTHER; PTHR11521:SF4; PTHR11521:SF4; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Muscle protein;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..263
FT /note="Troponin T, fast skeletal muscle isoforms"
FT /id="PRO_0000186183"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 12..35
FT /note="EEYEEEAHEAEEVHEEEVHEPAPP -> AHEAEEVHEEAHHEEAHHAEAHHE
FT EAHAHAEEVHE (in isoform TNT-1)"
FT /evidence="ECO:0000303|PubMed:3198600"
FT /id="VSP_006633"
FT VAR_SEQ 12..17
FT /note="Missing (in isoform TNT-2 and isoform TNT-4)"
FT /evidence="ECO:0000303|PubMed:3198600"
FT /id="VSP_006634"
FT VAR_SEQ 39..44
FT /note="Missing (in isoform TNT-4)"
FT /evidence="ECO:0000303|PubMed:3198600"
FT /id="VSP_006635"
FT VAR_SEQ 236..248
FT /note="VTLRNRIDQAQKH -> LTLRCRLQELSKF (in isoform TNT-2)"
FT /evidence="ECO:0000303|PubMed:3198600"
FT /id="VSP_006636"
FT TURN 70..73
FT /evidence="ECO:0007829|PDB:2Z5H"
FT HELIX 74..77
FT /evidence="ECO:0007829|PDB:2Z5H"
FT TURN 78..84
FT /evidence="ECO:0007829|PDB:2Z5H"
FT STRAND 85..91
FT /evidence="ECO:0007829|PDB:2Z5H"
FT TURN 92..94
FT /evidence="ECO:0007829|PDB:2Z5H"
FT TURN 96..98
FT /evidence="ECO:0007829|PDB:2Z5H"
FT HELIX 164..188
FT /evidence="ECO:0007829|PDB:1YTZ"
FT STRAND 196..198
FT /evidence="ECO:0007829|PDB:1YTZ"
FT HELIX 202..244
FT /evidence="ECO:0007829|PDB:1YTZ"
SQ SEQUENCE 263 AA; 31142 MW; DBBB46419CCE6FAC CRC64;
MSDTEEVEHG EEEYEEEAHE AEEVHEEEVH EPAPPPEEAP EEEEKPRIKL TAPKIPEGEK
VDFDDIQKKR QNKDLIELQA LIDSHFEARR KEEEELVALK ERIEKRRAER AEQQRIRAEK
EKERQARLAE EKARREEEDA KRKAEDDLKK KKALSSMGAS YSSYLAKADQ KRGKKQTARE
TKKKVLAERR KPLNIDHLNE DKLRDKAKEL WDWLYQLQTE KYDFAEQIKR KKYEIVTLRN
RIDQAQKHSK KAGAKGKVGG RWK
