ID   TNNT2_SHEEP             Reviewed;         287 AA.
AC   P50751;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Troponin T, cardiac muscle;
DE            Short=TnTc;
DE   AltName: Full=Cardiac muscle troponin T;
DE            Short=cTnT;
GN   Name=TNNT2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Fetal heart;
RX   PubMed=1866215; DOI=10.1203/00006450-199106010-00012;
RA   McAuliffe J.J., Robbins J.;
RT   "Troponin T expression in normal and pressure-loaded fetal sheep heart.";
RL   Pediatr. Res. 29:580-585(1991).
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC   -!- DEVELOPMENTAL STAGE: Expressed from midgestation to adult life.
CC   -!- PTM: Phosphorylation at Thr-202 by PRKCA induces significant reduction
CC       in myofilament calcium sensitivity and actomyosin ATPase activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P50751; -.
DR   PRIDE; P50751; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR   GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; PTHR11521; 1.
DR   Pfam; PF00992; Troponin; 2.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Muscle protein; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P09741"
FT   CHAIN           2..287
FT                   /note="Troponin T, cardiac muscle"
FT                   /id="PRO_0000186177"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P09741"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250|UniProtKB:P13789"
FT   MOD_RES         197
FT                   /note="Phosphoserine; by PKC/PRKCA"
FT                   /evidence="ECO:0000250|UniProtKB:P50752"
FT   MOD_RES         202
FT                   /note="Phosphothreonine; by PKC/PRKCA and RAF1"
FT                   /evidence="ECO:0000250|UniProtKB:P13789"
FT   MOD_RES         283
FT                   /note="Phosphothreonine; by PKC/PRKCA"
FT                   /evidence="ECO:0000250|UniProtKB:P13789"
SQ   SEQUENCE   287 AA;  33764 MW;  0AC80AAE862A080A CRC64;
     MSDVEETVDE YEEQEEAAVE EHEESVEEEA GGEARQGGGA SAAEDGEEEE GREAEDGPVE
     ESKPQAPGPF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQTLIEAHF ENRKKEEEEL
     VSLKDRIEKR RAERAEQQRI RTEREKERQA RLAEERARRE EEESRRKAED EARKKKALSN
     MMHFGGYIQK AQAERKSGKR QTEREKKKKI LAERRKVLAI DHLNEDQLRE KARELWQSIY
     DLEAEKFDLQ EKFKQQKYEI NVLRNRVNDN QKVSKTRGKA KVTGRWK