ID   TNNT2_CHICK             Reviewed;         302 AA.
AC   P02642;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Troponin T, cardiac muscle isoforms;
DE            Short=TnTC;
GN   Name=TNNT2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=2993302; DOI=10.1016/s0021-9258(17)39158-5;
RA   Cooper T.A., Ordahl C.P.;
RT   "A single cardiac troponin T gene generates embryonic and adult isoforms
RT   via developmentally regulated alternate splicing.";
RL   J. Biol. Chem. 260:11140-11148(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 68-302.
RX   PubMed=6095446; DOI=10.1126/science.6095446;
RA   Cooper T.A., Ordahl C.P.;
RT   "A single troponin T gene regulated by different programs in cardiac and
RT   skeletal muscle development.";
RL   Science 226:979-982(1984).
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Embryonic;
CC         IsoId=P02642-1; Sequence=Displayed;
CC       Name=2; Synonyms=Adult;
CC         IsoId=P02642-2; Sequence=VSP_006632;
CC   -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR   EMBL; M10013; AAA49099.1; -; mRNA.
DR   EMBL; K02263; AAA49098.1; -; mRNA.
DR   PIR; A25373; TPCHTC.
DR   RefSeq; NP_990780.1; NM_205449.1. [P02642-1]
DR   AlphaFoldDB; P02642; -.
DR   STRING; 9031.ENSGALP00000000400; -.
DR   PaxDb; P02642; -.
DR   GeneID; 396433; -.
DR   KEGG; gga:396433; -.
DR   CTD; 7139; -.
DR   VEuPathDB; HostDB:geneid_396433; -.
DR   eggNOG; KOG3634; Eukaryota.
DR   InParanoid; P02642; -.
DR   OrthoDB; 1480247at2759; -.
DR   PhylomeDB; P02642; -.
DR   PRO; PR:P02642; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR   GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR   GO; GO:0030172; F:troponin C binding; IBA:GO_Central.
DR   GO; GO:0031013; F:troponin I binding; IBA:GO_Central.
DR   GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR   GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; PTHR11521; 1.
DR   Pfam; PF00992; Troponin; 1.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Muscle protein; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..302
FT                   /note="Troponin T, cardiac muscle isoforms"
FT                   /id="PRO_0000186182"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..53
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         23..32
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:2993302"
FT                   /id="VSP_006632"
SQ   SEQUENCE   302 AA;  35986 MW;  7CCE0112906D5FA8 CRC64;
     MSDSEEVVEE YEQEQEEEYV EEEEEEWLEE DDGQEDQVDE EEEETEETTA EEQEDETKAP
     GEGGEGDREQ EPGEGESKPK PKPFMPNLVP PKIPDGERLD FDDIHRKRME KDLNELQALI
     EAHFESRKKE EEELISLKDR IEQRRAERAE QQRIRSEREK ERQARMAEER ARKEEEEARK
     KAEKEARKKK AFSNMLHFGG YMQKSEKKGG KKQTEREKKK KILSERRKPL NIDHLSEDKL
     RDKAKELWQT IRDLEAEKFD LQEKFKRQKY EINVLRNRVS DHQKVKGSKA ARGKTMVGGR
     WK