TNNT1_RAT
ID TNNT1_RAT Reviewed; 261 AA.
AC Q7TNB2; Q7TNA9; Q7TNB0; Q7TNB1; Q923S7;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Troponin T, slow skeletal muscle;
DE Short=TnTs;
DE AltName: Full=Slow skeletal muscle troponin T;
DE Short=sTnT;
GN Name=Tnnt1; Synonyms=Fang2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND TISSUE
RP SPECIFICITY.
RC STRAIN=Wistar;
RX PubMed=15788488; DOI=10.1152/ajpcell.00365.2004;
RA Kischel P., Bastide B., Muller M., Dubail F., Offredi F., Jin J.-P.,
RA Mounier Y., Martial J.;
RT "Expression and functional properties of four slow skeletal troponin T
RT isoforms in rat muscles.";
RL Am. J. Physiol. 289:C437-C443(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley;
RA Chang Y.Y., Zuo J.J., Fang F.F.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=sTnT1;
CC IsoId=Q7TNB2-1; Sequence=Displayed;
CC Name=2; Synonyms=sTnT2;
CC IsoId=Q7TNB2-2; Sequence=VSP_013790;
CC Name=3; Synonyms=sTnT3;
CC IsoId=Q7TNB2-3; Sequence=VSP_013789, VSP_013790;
CC Name=4; Synonyms=sTnTx;
CC IsoId=Q7TNB2-4; Sequence=VSP_013789;
CC -!- TISSUE SPECIFICITY: Expressed in soleus muscle. Isoform 4 is
CC predominantly expressed in fast muscles. {ECO:0000269|PubMed:15788488}.
CC -!- MISCELLANEOUS: [Isoform 1]: Major.
CC -!- MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Minor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: Minor. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK94010.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY334079; AAQ19259.1; -; mRNA.
DR EMBL; AY334080; AAQ19260.1; -; mRNA.
DR EMBL; AY334081; AAQ19261.1; -; mRNA.
DR EMBL; AY334082; AAQ19262.1; -; mRNA.
DR EMBL; AF399874; AAK94010.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001264189.1; NM_001277260.1. [Q7TNB2-2]
DR RefSeq; NP_001264190.1; NM_001277261.2. [Q7TNB2-3]
DR RefSeq; NP_001264191.1; NM_001277262.2. [Q7TNB2-4]
DR RefSeq; NP_599215.2; NM_134388.2. [Q7TNB2-1]
DR AlphaFoldDB; Q7TNB2; -.
DR SMR; Q7TNB2; -.
DR STRING; 10116.ENSRNOP00000038327; -.
DR iPTMnet; Q7TNB2; -.
DR PhosphoSitePlus; Q7TNB2; -.
DR jPOST; Q7TNB2; -.
DR PaxDb; Q7TNB2; -.
DR PRIDE; Q7TNB2; -.
DR Ensembl; ENSRNOT00000034957; ENSRNOP00000038327; ENSRNOG00000028041. [Q7TNB2-1]
DR Ensembl; ENSRNOT00000058843; ENSRNOP00000055633; ENSRNOG00000028041. [Q7TNB2-4]
DR GeneID; 171409; -.
DR KEGG; rno:171409; -.
DR UCSC; RGD:621852; rat. [Q7TNB2-1]
DR CTD; 7138; -.
DR RGD; 621852; Tnnt1.
DR eggNOG; KOG3634; Eukaryota.
DR GeneTree; ENSGT00940000160609; -.
DR InParanoid; Q7TNB2; -.
DR OMA; EWIYELE; -.
DR OrthoDB; 1480247at2759; -.
DR PhylomeDB; Q7TNB2; -.
DR Reactome; R-RNO-390522; Striated Muscle Contraction.
DR PRO; PR:Q7TNB2; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000028041; Expressed in esophagus and 17 other tissues.
DR Genevisible; Q7TNB2; RN.
DR GO; GO:0005861; C:troponin complex; IDA:RGD.
DR GO; GO:0005523; F:tropomyosin binding; ISO:RGD.
DR GO; GO:0031014; F:troponin T binding; IDA:RGD.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0045932; P:negative regulation of muscle contraction; ISO:RGD.
DR GO; GO:0006937; P:regulation of muscle contraction; IDA:RGD.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR GO; GO:0003009; P:skeletal muscle contraction; ISO:RGD.
DR GO; GO:0031444; P:slow-twitch skeletal muscle fiber contraction; IDA:RGD.
DR GO; GO:0014883; P:transition between fast and slow fiber; ISO:RGD.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; PTHR11521; 1.
DR Pfam; PF00992; Troponin; 2.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Muscle protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..261
FT /note="Troponin T, slow skeletal muscle"
FT /id="PRO_0000186171"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 24..34
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15788488"
FT /id="VSP_013789"
FT VAR_SEQ 35
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15788488"
FT /id="VSP_013790"
SQ SEQUENCE 261 AA; 31215 MW; B323364DBCAB5863 CRC64;
MSDTEEQEYE EEQAEDEEAV EEEAPEEPEP VAEREEERPK PSRPVVPPLI PPKIPEGERV
DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD RIERRRAERA EQQRFRTEKE
RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM
KLRILSERKK PLNIDYMGED QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR
ISHAQKFRKG AGKGRVGGRW K
