TNNT1_PIG
ID TNNT1_PIG Reviewed; 262 AA.
AC Q75ZZ6; Q75ZZ5;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Troponin T, slow skeletal muscle;
DE Short=TnTs;
DE AltName: Full=Slow skeletal muscle troponin T;
DE Short=sTnT;
GN Name=TNNT1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Large white X Landrace X Duroc; TISSUE=Skeletal muscle;
RX PubMed=16556993; DOI=10.1271/bbb.70.726;
RA Kitamura S., Muroya S., Nakajima I., Chikuni K., Nishimura T.;
RT "Amino acid sequences of porcine fast and slow troponin T isoforms.";
RL Biosci. Biotechnol. Biochem. 70:726-728(2006).
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=sTnT1;
CC IsoId=Q75ZZ6-1; Sequence=Displayed;
CC Name=2; Synonyms=sTnT2;
CC IsoId=Q75ZZ6-2; Sequence=VSP_013788;
CC -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR EMBL; AB118908; BAC82459.1; -; mRNA.
DR EMBL; AB118909; BAC82460.1; -; mRNA.
DR RefSeq; NP_998913.1; NM_213748.2. [Q75ZZ6-1]
DR RefSeq; XP_005656022.1; XM_005655965.2. [Q75ZZ6-1]
DR RefSeq; XP_005656023.1; XM_005655966.2. [Q75ZZ6-2]
DR AlphaFoldDB; Q75ZZ6; -.
DR SMR; Q75ZZ6; -.
DR STRING; 9823.ENSSSCP00000026745; -.
DR PaxDb; Q75ZZ6; -.
DR PeptideAtlas; Q75ZZ6; -.
DR PRIDE; Q75ZZ6; -.
DR Ensembl; ENSSSCT00000044398; ENSSSCP00000035280; ENSSSCG00000025353. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00025083627; ENSSSCP00025036385; ENSSSCG00025060477. [Q75ZZ6-1]
DR Ensembl; ENSSSCT00030072701; ENSSSCP00030033179; ENSSSCG00030052097. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00035050051; ENSSSCP00035020037; ENSSSCG00035037707. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00040027807; ENSSSCP00040011724; ENSSSCG00040020546. [Q75ZZ6-1]
DR Ensembl; ENSSSCT00040027904; ENSSSCP00040011781; ENSSSCG00040020546. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00045018072; ENSSSCP00045012446; ENSSSCG00045010614. [Q75ZZ6-1]
DR Ensembl; ENSSSCT00045018117; ENSSSCP00045012478; ENSSSCG00045010614. [Q75ZZ6-1]
DR Ensembl; ENSSSCT00050084414; ENSSSCP00050036241; ENSSSCG00050061966. [Q75ZZ6-1]
DR Ensembl; ENSSSCT00050084454; ENSSSCP00050036260; ENSSSCG00050061966. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00055027328; ENSSSCP00055021740; ENSSSCG00055013544. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00060053453; ENSSSCP00060022776; ENSSSCG00060039415. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00065027045; ENSSSCP00065011108; ENSSSCG00065020272. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00070045443; ENSSSCP00070038307; ENSSSCG00070022767. [Q75ZZ6-2]
DR Ensembl; ENSSSCT00070046027; ENSSSCP00070038811; ENSSSCG00070022767. [Q75ZZ6-1]
DR GeneID; 396579; -.
DR KEGG; ssc:396579; -.
DR CTD; 7138; -.
DR eggNOG; KOG3634; Eukaryota.
DR GeneTree; ENSGT00940000160609; -.
DR HOGENOM; CLU_076377_0_0_1; -.
DR InParanoid; Q75ZZ6; -.
DR OMA; EWIYELE; -.
DR OrthoDB; 1480247at2759; -.
DR TreeFam; TF313321; -.
DR Reactome; R-SSC-390522; Striated Muscle Contraction.
DR Proteomes; UP000008227; Chromosome 6.
DR Proteomes; UP000314985; Chromosome 6.
DR Bgee; ENSSSCG00000025353; Expressed in longissimus lumborum muscle and 31 other tissues.
DR ExpressionAtlas; Q75ZZ6; baseline.
DR Genevisible; Q75ZZ6; SS.
DR GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR GO; GO:0031014; F:troponin T binding; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR GO; GO:0031444; P:slow-twitch skeletal muscle fiber contraction; IBA:GO_Central.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; PTHR11521; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Muscle protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..262
FT /note="Troponin T, slow skeletal muscle"
FT /id="PRO_0000186170"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 25..35
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16556993"
FT /id="VSP_013788"
SQ SEQUENCE 262 AA; 31243 MW; 60620D5AB505C400 CRC64;
MSDAEEQEYE EEQPEEEEAA EEEEAPEEPE PVAEREEERP KPSRPVVPPL IPPKIPEGER
VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRAER AEQQRFRTEK
ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE
MKQRILSERK KPLNIDHMGE DQLREKAQEL SDWIHQLESE KFDLMAKLKQ QKYEINVLYN
RISHAQKFRK GAGKGRVGGR WK
