TNNT1_MOUSE
ID TNNT1_MOUSE Reviewed; 262 AA.
AC O88346; B7ZNV5; B7ZNV6; O88795; Q9QUP7;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Troponin T, slow skeletal muscle;
DE Short=TnTs;
DE AltName: Full=Slow skeletal muscle troponin T;
DE Short=sTnT;
GN Name=Tnnt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=129/SvJ; TISSUE=Skeletal muscle;
RX PubMed=9651500; DOI=10.1016/s0378-1119(98)00214-5;
RA Jin J.-P., Chen A., Huang Q.-Q.;
RT "Three alternatively spliced mouse slow skeletal muscle troponin T
RT isoforms: conserved primary structure and regulated expression during
RT postnatal development.";
RL Gene 214:121-129(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=11003710; DOI=10.1007/s003350010171;
RA Barton P.J.R., Mullen A.J., Cullen M.E., Dhoot G.K., Simon-Chazottes D.,
RA Guenet J.-L.;
RT "Genes encoding troponin I and troponin T are organized as three paralogous
RT pairs in the mouse genome.";
RL Mamm. Genome 11:926-929(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129; TISSUE=Skeletal muscle;
RX PubMed=10095098; DOI=10.1016/s0378-1119(99)00051-7;
RA Huang Q.-Q., Chen A., Jin J.-P.;
RT "Genomic sequence and structural organization of mouse slow skeletal muscle
RT troponin T gene.";
RL Gene 229:1-10(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=High Mr-1;
CC IsoId=O88346-1; Sequence=Displayed;
CC Name=2; Synonyms=High Mr-2;
CC IsoId=O88346-2; Sequence=VSP_013787;
CC Name=3; Synonyms=Low Mr;
CC IsoId=O88346-3; Sequence=VSP_013786;
CC -!- TISSUE SPECIFICITY: Expressed in adult soleus muscle.
CC {ECO:0000269|PubMed:9651500}.
CC -!- DEVELOPMENTAL STAGE: In masseter expression decreases during
CC development and becomes undetectable 3 weeks after birth.
CC {ECO:0000269|PubMed:9651500}.
CC -!- MISCELLANEOUS: [Isoform 1]: Major.
CC -!- MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Minor. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF020946; AAC32546.1; -; mRNA.
DR EMBL; U92883; AAC32540.1; -; mRNA.
DR EMBL; U92884; AAC32541.1; -; mRNA.
DR EMBL; AJ131711; CAB38082.1; -; mRNA.
DR EMBL; U92882; AAD00730.1; -; Genomic_DNA.
DR EMBL; BC141142; AAI41143.1; -; mRNA.
DR EMBL; BC145450; AAI45451.1; -; mRNA.
DR EMBL; BC145451; AAI45452.1; -; mRNA.
DR CCDS; CCDS51973.1; -. [O88346-2]
DR CCDS; CCDS71879.1; -. [O88346-3]
DR CCDS; CCDS71880.1; -. [O88346-1]
DR RefSeq; NP_001264832.1; NM_001277903.1. [O88346-1]
DR RefSeq; NP_001264833.1; NM_001277904.1. [O88346-3]
DR RefSeq; NP_035748.1; NM_011618.2. [O88346-2]
DR AlphaFoldDB; O88346; -.
DR SMR; O88346; -.
DR STRING; 10090.ENSMUSP00000071704; -.
DR iPTMnet; O88346; -.
DR PhosphoSitePlus; O88346; -.
DR MaxQB; O88346; -.
DR PaxDb; O88346; -.
DR PRIDE; O88346; -.
DR ProteomicsDB; 259602; -. [O88346-1]
DR ProteomicsDB; 259603; -. [O88346-2]
DR ProteomicsDB; 259604; -. [O88346-3]
DR Antibodypedia; 4195; 276 antibodies from 34 providers.
DR DNASU; 21955; -.
DR Ensembl; ENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179. [O88346-2]
DR Ensembl; ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179. [O88346-1]
DR Ensembl; ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179. [O88346-3]
DR GeneID; 21955; -.
DR KEGG; mmu:21955; -.
DR UCSC; uc009exu.2; mouse. [O88346-1]
DR UCSC; uc012ewu.2; mouse. [O88346-3]
DR CTD; 7138; -.
DR MGI; MGI:1333868; Tnnt1.
DR VEuPathDB; HostDB:ENSMUSG00000064179; -.
DR eggNOG; KOG3634; Eukaryota.
DR GeneTree; ENSGT00940000160609; -.
DR InParanoid; O88346; -.
DR OMA; EWIYELE; -.
DR OrthoDB; 1480247at2759; -.
DR PhylomeDB; O88346; -.
DR TreeFam; TF313321; -.
DR Reactome; R-MMU-390522; Striated Muscle Contraction.
DR BioGRID-ORCS; 21955; 0 hits in 74 CRISPR screens.
DR PRO; PR:O88346; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; O88346; protein.
DR Bgee; ENSMUSG00000064179; Expressed in soleus muscle and 186 other tissues.
DR ExpressionAtlas; O88346; baseline and differential.
DR Genevisible; O88346; MM.
DR GO; GO:0005861; C:troponin complex; ISO:MGI.
DR GO; GO:0005523; F:tropomyosin binding; ISO:MGI.
DR GO; GO:0031014; F:troponin T binding; ISO:MGI.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0045932; P:negative regulation of muscle contraction; ISO:MGI.
DR GO; GO:0006937; P:regulation of muscle contraction; ISO:MGI.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR GO; GO:0003009; P:skeletal muscle contraction; ISO:MGI.
DR GO; GO:0031444; P:slow-twitch skeletal muscle fiber contraction; ISO:MGI.
DR GO; GO:0014883; P:transition between fast and slow fiber; IDA:MGI.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; PTHR11521; 1.
DR Pfam; PF00992; Troponin; 2.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Muscle protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..262
FT /note="Troponin T, slow skeletal muscle"
FT /id="PRO_0000186169"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 24..35
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9651500"
FT /id="VSP_013786"
FT VAR_SEQ 38
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9651500"
FT /id="VSP_013787"
SQ SEQUENCE 262 AA; 31344 MW; E0B0FE519714FBE1 CRC64;
MSDTEEQEYE EEQAEDEEAV EEEEAPEEPE PVAEREEERP KPSRPVVPPL IPPKIPEGER
VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELIALK DRIERRRAER AEQQRFRTEK
ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE
MKLRILSERK KPLNIDYMGE DQLREKAQEL SEWIHQLESE KFDLMEKLKQ QKYEINVLYN
RISHAQKFRK GAGKGRVGGR WK
