ID   TNNT1_BOVIN             Reviewed;         263 AA.
AC   Q8MKH6; Q148J9; Q8MKH5;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Troponin T, slow skeletal muscle;
DE            Short=TnTs;
DE   AltName: Full=Slow skeletal muscle troponin T;
DE            Short=sTnT;
GN   Name=TNNT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC   STRAIN=Holstein; TISSUE=Skeletal muscle;
RX   PubMed=12772845; DOI=10.2527/2003.8151185x;
RA   Muroya S., Nakajima I., Chikuni K.;
RT   "Amino acid sequences of multiple fast and slow troponin T isoforms
RT   expressed in adult bovine skeletal muscles.";
RL   J. Anim. Sci. 81:1185-1192(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=sTnT1;
CC         IsoId=Q8MKH6-1; Sequence=Displayed;
CC       Name=2; Synonyms=sTnT2;
CC         IsoId=Q8MKH6-2; Sequence=VSP_013785;
CC   -!- TISSUE SPECIFICITY: Expressed dominantly in slow muscles, like
CC       masseter, diaphragm, psoas major and spinnalis. Isoform 2 is also
CC       expressed in fast muscles. {ECO:0000269|PubMed:12772845}.
CC   -!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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DR   EMBL; AB085601; BAB92984.1; -; mRNA.
DR   EMBL; AB085600; BAB92983.1; -; mRNA.
DR   EMBL; BC118248; AAI18249.1; -; mRNA.
DR   RefSeq; NP_776899.1; NM_174474.1. [Q8MKH6-1]
DR   RefSeq; XP_005219724.1; XM_005219667.3. [Q8MKH6-1]
DR   RefSeq; XP_005219728.1; XM_005219671.3. [Q8MKH6-2]
DR   RefSeq; XP_010813770.1; XM_010815468.1. [Q8MKH6-1]
DR   AlphaFoldDB; Q8MKH6; -.
DR   SMR; Q8MKH6; -.
DR   STRING; 9913.ENSBTAP00000008420; -.
DR   PaxDb; Q8MKH6; -.
DR   PRIDE; Q8MKH6; -.
DR   Ensembl; ENSBTAT00000008420; ENSBTAP00000008420; ENSBTAG00000006419. [Q8MKH6-1]
DR   Ensembl; ENSBTAT00000064903; ENSBTAP00000054828; ENSBTAG00000006419. [Q8MKH6-1]
DR   GeneID; 282095; -.
DR   KEGG; bta:282095; -.
DR   CTD; 7138; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006419; -.
DR   eggNOG; KOG3634; Eukaryota.
DR   GeneTree; ENSGT00940000160609; -.
DR   HOGENOM; CLU_076377_0_0_1; -.
DR   InParanoid; Q8MKH6; -.
DR   OMA; EWIYELE; -.
DR   OrthoDB; 1480247at2759; -.
DR   TreeFam; TF313321; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000006419; Expressed in laryngeal cartilage and 89 other tissues.
DR   ExpressionAtlas; Q8MKH6; baseline.
DR   GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR   GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR   GO; GO:0031014; F:troponin T binding; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR   GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR   GO; GO:0031444; P:slow-twitch skeletal muscle fiber contraction; IBA:GO_Central.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; PTHR11521; 1.
DR   Pfam; PF00992; Troponin; 2.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Muscle protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Troponin T, slow skeletal muscle"
FT                   /id="PRO_0000186167"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         26..36
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12772845"
FT                   /id="VSP_013785"
SQ   SEQUENCE   263 AA;  31284 MW;  0BA8E503EE3DE885 CRC64;
     MSDAEEQEYE EEQPEEEEAA EEEEEAPEEP EPAAEPEEER PKPSRPVVPP LIPPKIPEGE
     RVDFDDIHRK RMEKDLLELQ TLIDVHFEQR KKEEEELVAL KERIERRRAE RAEQQRFRTE
     KERERQAKLA EEKMRKEEEE AKKRAEDDAK KKKVLSNMGA HFGGYLVKAE QKRGKRQTGR
     EMKLRILSER KKPLNIDHMG EEQLREKAQE LSDWIHQLES EKFDLMAKLK QQKYEINVLY
     NRISHAQKFR KGAGKGRVGG RWK