ID   TNNI4_CAEEL             Reviewed;         194 AA.
AC   O44572; Q5FBV3;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Troponin I 4;
DE            Short=CeTNI-4;
DE            Short=TnI 4;
GN   Name=tni-4; ORFNames=W03F8.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=15743415; DOI=10.1111/j.1365-2443.2005.00829.x;
RA   Ruksana R., Kuroda K., Terami H., Bando T., Kitaoka S., Takaya T.,
RA   Sakube Y., Kagawa H.;
RT   "Tissue expression of four troponin I genes and their molecular
RT   interactions with two troponin C isoforms in Caenorhabditis elegans.";
RL   Genes Cells 10:261-276(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=14747334; DOI=10.1016/s0006-3495(04)74174-0;
RA   Burkeen A.K., Maday S.L., Rybicka K.K., Sulcove J.A., Ward J., Huang M.M.,
RA   Barstead R., Franzini-Armstrong C., Allen T.S.;
RT   "Disruption of Caenorhabditis elegans muscle structure and function caused
RT   by mutation of troponin I.";
RL   Biophys. J. 86:991-1001(2004).
CC   -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC       filament regulatory complex which confers calcium-sensitivity to muscle
CC       actomyosin ATPase activity. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expression is detected only in pharyngeal muscle
CC       cells from embryos to adults. {ECO:0000269|PubMed:14747334,
CC       ECO:0000269|PubMed:15743415}.
CC   -!- DISRUPTION PHENOTYPE: Worms exhibit developmental arrest at
CC       gastrulation. {ECO:0000269|PubMed:15743415}.
CC   -!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB107583; BAD89381.1; -; Genomic_DNA.
DR   EMBL; FO080652; CCD65507.1; -; Genomic_DNA.
DR   PIR; T15106; T15106.
DR   RefSeq; NP_500741.2; NM_068340.6.
DR   AlphaFoldDB; O44572; -.
DR   SMR; O44572; -.
DR   BioGRID; 42420; 6.
DR   DIP; DIP-25124N; -.
DR   STRING; 6239.W03F8.1; -.
DR   iPTMnet; O44572; -.
DR   EPD; O44572; -.
DR   PaxDb; O44572; -.
DR   PeptideAtlas; O44572; -.
DR   PRIDE; O44572; -.
DR   EnsemblMetazoa; W03F8.1.1; W03F8.1.1; WBGene00006586.
DR   GeneID; 177295; -.
DR   KEGG; cel:CELE_W03F8.1; -.
DR   UCSC; W03F8.1; c. elegans.
DR   CTD; 177295; -.
DR   WormBase; W03F8.1; CE29829; WBGene00006586; tni-4.
DR   eggNOG; KOG3977; Eukaryota.
DR   GeneTree; ENSGT01030000234588; -.
DR   HOGENOM; CLU_053937_2_0_1; -.
DR   InParanoid; O44572; -.
DR   OMA; WDLEFEV; -.
DR   OrthoDB; 1566919at2759; -.
DR   PhylomeDB; O44572; -.
DR   Reactome; R-CEL-5578775; Ion homeostasis.
DR   PRO; PR:O44572; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006586; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0030017; C:sarcomere; IDA:WormBase.
DR   GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030172; F:troponin C binding; IPI:WormBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0043050; P:pharyngeal pumping; IMP:WormBase.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   Pfam; PF00992; Troponin; 1.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Muscle protein; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Troponin I 4"
FT                   /id="PRO_0000186164"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  23060 MW;  838CBD45510A1FB8 CRC64;
     MSDVDADEAR KMAERERKKE EVRKRLEEAS RMKKAKKGFL TPERKKKLRK LLMMKAAEDL
     KQQQMLKEQE RQRILQERII PLPDLDNEDD LEAVYDEIRE RLIDLESENY DVSYIVRQKD
     FEINELTIAV NDLRGKFVKP TLKKVSKTEG KFDKLKKKEA TKVDFRAQLK VVDKNEFALD
     EEDTEKKEKA AWAK