TNNI2_MOUSE
ID TNNI2_MOUSE Reviewed; 182 AA.
AC P13412; A2A6J9;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Troponin I, fast skeletal muscle;
DE AltName: Full=Troponin I, fast-twitch isoform;
GN Name=Tnni2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2760067; DOI=10.1016/s0021-9258(18)71681-5;
RA Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.;
RT "cDNA clone and expression analysis of rodent fast and slow skeletal muscle
RT troponin I mRNAs.";
RL J. Biol. Chem. 264:14327-14333(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC -!- SUBUNIT: Binds to actin and tropomyosin.
CC -!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; J04992; AAA40485.1; -; mRNA.
DR EMBL; AL603651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028515; AAH28515.1; -; mRNA.
DR CCDS; CCDS40192.1; -.
DR PIR; A44786; A44786.
DR RefSeq; NP_033431.1; NM_009405.2.
DR RefSeq; XP_006508602.1; XM_006508539.3.
DR AlphaFoldDB; P13412; -.
DR BMRB; P13412; -.
DR SMR; P13412; -.
DR BioGRID; 204265; 10.
DR STRING; 10090.ENSMUSP00000122733; -.
DR iPTMnet; P13412; -.
DR PhosphoSitePlus; P13412; -.
DR SWISS-2DPAGE; P13412; -.
DR MaxQB; P13412; -.
DR PaxDb; P13412; -.
DR PRIDE; P13412; -.
DR ProteomicsDB; 259142; -.
DR Antibodypedia; 4359; 449 antibodies from 34 providers.
DR DNASU; 21953; -.
DR Ensembl; ENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
DR Ensembl; ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
DR GeneID; 21953; -.
DR KEGG; mmu:21953; -.
DR UCSC; uc033jdj.1; mouse.
DR CTD; 7136; -.
DR MGI; MGI:105070; Tnni2.
DR VEuPathDB; HostDB:ENSMUSG00000031097; -.
DR eggNOG; KOG3977; Eukaryota.
DR GeneTree; ENSGT01030000234588; -.
DR InParanoid; P13412; -.
DR OMA; KRHRAIT; -.
DR OrthoDB; 1566919at2759; -.
DR PhylomeDB; P13412; -.
DR TreeFam; TF313374; -.
DR Reactome; R-MMU-390522; Striated Muscle Contraction.
DR BioGRID-ORCS; 21953; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tnni2; mouse.
DR PRO; PR:P13412; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P13412; protein.
DR Bgee; ENSMUSG00000031097; Expressed in digastric muscle group and 129 other tissues.
DR ExpressionAtlas; P13412; baseline and differential.
DR Genevisible; P13412; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005861; C:troponin complex; ISO:MGI.
DR GO; GO:0003779; F:actin binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031014; F:troponin T binding; ISO:MGI.
DR GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006937; P:regulation of muscle contraction; ISO:MGI.
DR GO; GO:0003009; P:skeletal muscle contraction; ISO:MGI.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; SSF90250; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Actin-binding; Muscle protein; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02643"
FT CHAIN 2..182
FT /note="Troponin I, fast skeletal muscle"
FT /id="PRO_0000186144"
FT REGION 2..48
FT /note="Involved in binding TNC"
FT REGION 29..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..117
FT /note="Involved in binding TNC and actin"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylglycine"
FT /evidence="ECO:0000250|UniProtKB:P02643"
FT MOD_RES 12
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P02643"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02643"
SQ SEQUENCE 182 AA; 21358 MW; B09B6657CC85F73C CRC64;
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP PLHIPGSMSE
VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD
AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES
ES
