TMUB2_HUMAN
ID TMUB2_HUMAN Reviewed; 321 AA.
AC Q71RG4; B3KU81; Q8NDI2; Q9BPZ5; Q9HAG3;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 2;
GN Name=TMUB2; ORFNames=FP2653, UNQ1897/PRO4343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain, and Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Brain, Eye, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q71RG4; Q13520: AQP6; NbExp=3; IntAct=EBI-2820477, EBI-13059134;
CC Q71RG4; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-2820477, EBI-11343438;
CC Q71RG4; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-2820477, EBI-747430;
CC Q71RG4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2820477, EBI-781551;
CC Q71RG4; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2820477, EBI-18304435;
CC Q71RG4; O75712: GJB3; NbExp=3; IntAct=EBI-2820477, EBI-3908586;
CC Q71RG4; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-2820477, EBI-712073;
CC Q71RG4; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2820477, EBI-11721746;
CC Q71RG4; Q13651: IL10RA; NbExp=3; IntAct=EBI-2820477, EBI-1031656;
CC Q71RG4; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-2820477, EBI-12820341;
CC Q71RG4; O14524-2: NEMP1; NbExp=3; IntAct=EBI-2820477, EBI-10969203;
CC Q71RG4; O43765: SGTA; NbExp=3; IntAct=EBI-2820477, EBI-347996;
CC Q71RG4; Q14973: SLC10A1; NbExp=3; IntAct=EBI-2820477, EBI-3923031;
CC Q71RG4; Q9UPZ6: THSD7A; NbExp=3; IntAct=EBI-2820477, EBI-310962;
CC Q71RG4; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-2820477, EBI-18178701;
CC Q71RG4; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-2820477, EBI-10173939;
CC Q71RG4; O75841: UPK1B; NbExp=3; IntAct=EBI-2820477, EBI-12237619;
CC Q71RG4-4; Q92870-2: APBB2; NbExp=3; IntAct=EBI-25831574, EBI-21535880;
CC Q71RG4-4; P54253: ATXN1; NbExp=3; IntAct=EBI-25831574, EBI-930964;
CC Q71RG4-4; P28329-3: CHAT; NbExp=3; IntAct=EBI-25831574, EBI-25837549;
CC Q71RG4-4; Q14203-5: DCTN1; NbExp=3; IntAct=EBI-25831574, EBI-25840379;
CC Q71RG4-4; G5E9A7: DMWD; NbExp=3; IntAct=EBI-25831574, EBI-10976677;
CC Q71RG4-4; P22607: FGFR3; NbExp=3; IntAct=EBI-25831574, EBI-348399;
CC Q71RG4-4; O15354: GPR37; NbExp=3; IntAct=EBI-25831574, EBI-15639515;
CC Q71RG4-4; P28799: GRN; NbExp=3; IntAct=EBI-25831574, EBI-747754;
CC Q71RG4-4; P28799-2: GRN; NbExp=3; IntAct=EBI-25831574, EBI-25860013;
CC Q71RG4-4; P06396: GSN; NbExp=3; IntAct=EBI-25831574, EBI-351506;
CC Q71RG4-4; P04792: HSPB1; NbExp=3; IntAct=EBI-25831574, EBI-352682;
CC Q71RG4-4; P42858: HTT; NbExp=6; IntAct=EBI-25831574, EBI-466029;
CC Q71RG4-4; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-25831574, EBI-1055254;
CC Q71RG4-4; O60333-2: KIF1B; NbExp=3; IntAct=EBI-25831574, EBI-10975473;
CC Q71RG4-4; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25831574, EBI-25882629;
CC Q71RG4-4; O60260-5: PRKN; NbExp=3; IntAct=EBI-25831574, EBI-21251460;
CC Q71RG4-4; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-25831574, EBI-396669;
CC Q71RG4-4; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25831574, EBI-5235340;
CC Q71RG4-4; Q86WV8: TSC1; NbExp=3; IntAct=EBI-25831574, EBI-12806590;
CC Q71RG4-4; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-25831574, EBI-741480;
CC Q71RG4-4; O76024: WFS1; NbExp=3; IntAct=EBI-25831574, EBI-720609;
CC Q71RG4-4; Q9Y649; NbExp=3; IntAct=EBI-25831574, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q71RG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q71RG4-2; Sequence=VSP_019700;
CC Name=3;
CC IsoId=Q71RG4-3; Sequence=VSP_019700, VSP_019703, VSP_019704;
CC Name=4;
CC IsoId=Q71RG4-4; Sequence=VSP_019700, VSP_019701, VSP_019702;
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DR EMBL; AF370373; AAQ15209.1; -; mRNA.
DR EMBL; AY358780; AAQ89140.1; -; mRNA.
DR EMBL; AK021759; BAB13886.1; -; mRNA.
DR EMBL; AK096631; BAG53343.1; -; mRNA.
DR EMBL; CR622157; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL833899; CAD38755.1; -; mRNA.
DR EMBL; BC001792; AAH01792.1; -; mRNA.
DR EMBL; BC004306; AAH04306.1; -; mRNA.
DR EMBL; BC063489; AAH63489.1; -; mRNA.
DR CCDS; CCDS11479.1; -. [Q71RG4-2]
DR CCDS; CCDS54134.1; -. [Q71RG4-1]
DR RefSeq; NP_001070142.1; NM_001076674.1. [Q71RG4-1]
DR RefSeq; NP_001317164.1; NM_001330235.1.
DR RefSeq; NP_077012.2; NM_024107.2. [Q71RG4-2]
DR RefSeq; NP_803190.2; NM_177441.2. [Q71RG4-2]
DR RefSeq; XP_011523500.1; XM_011525198.2.
DR RefSeq; XP_011523503.1; XM_011525201.2. [Q71RG4-1]
DR RefSeq; XP_011523507.1; XM_011525205.2. [Q71RG4-2]
DR RefSeq; XP_011523508.1; XM_011525206.2.
DR RefSeq; XP_011523509.1; XM_011525207.2.
DR RefSeq; XP_011523510.1; XM_011525208.2.
DR RefSeq; XP_011523511.1; XM_011525209.2.
DR RefSeq; XP_016880537.1; XM_017025048.1.
DR RefSeq; XP_016880538.1; XM_017025049.1.
DR RefSeq; XP_016880539.1; XM_017025050.1.
DR RefSeq; XP_016880540.1; XM_017025051.1.
DR AlphaFoldDB; Q71RG4; -.
DR SMR; Q71RG4; -.
DR BioGRID; 122537; 43.
DR DIP; DIP-60896N; -.
DR IntAct; Q71RG4; 50.
DR MINT; Q71RG4; -.
DR STRING; 9606.ENSP00000466971; -.
DR iPTMnet; Q71RG4; -.
DR PhosphoSitePlus; Q71RG4; -.
DR BioMuta; TMUB2; -.
DR DMDM; 110287995; -.
DR EPD; Q71RG4; -.
DR jPOST; Q71RG4; -.
DR MassIVE; Q71RG4; -.
DR MaxQB; Q71RG4; -.
DR PaxDb; Q71RG4; -.
DR PeptideAtlas; Q71RG4; -.
DR PRIDE; Q71RG4; -.
DR ProteomicsDB; 68616; -. [Q71RG4-1]
DR ProteomicsDB; 68617; -. [Q71RG4-2]
DR ProteomicsDB; 68618; -. [Q71RG4-3]
DR Antibodypedia; 29728; 80 antibodies from 16 providers.
DR DNASU; 79089; -.
DR Ensembl; ENST00000319511.6; ENSP00000313214.5; ENSG00000168591.16. [Q71RG4-2]
DR Ensembl; ENST00000357984.7; ENSP00000350672.3; ENSG00000168591.16. [Q71RG4-2]
DR Ensembl; ENST00000538716.7; ENSP00000444565.1; ENSG00000168591.16. [Q71RG4-1]
DR Ensembl; ENST00000587172.1; ENSP00000465153.1; ENSG00000168591.16. [Q71RG4-4]
DR Ensembl; ENST00000587989.1; ENSP00000466971.1; ENSG00000168591.16. [Q71RG4-1]
DR Ensembl; ENST00000589785.1; ENSP00000467364.1; ENSG00000168591.16. [Q71RG4-2]
DR Ensembl; ENST00000589856.1; ENSP00000467960.1; ENSG00000168591.16. [Q71RG4-3]
DR Ensembl; ENST00000590235.5; ENSP00000465015.1; ENSG00000168591.16. [Q71RG4-4]
DR Ensembl; ENST00000592825.1; ENSP00000466189.1; ENSG00000168591.16. [Q71RG4-4]
DR GeneID; 79089; -.
DR KEGG; hsa:79089; -.
DR MANE-Select; ENST00000538716.7; ENSP00000444565.1; NM_001076674.3; NP_001070142.1.
DR UCSC; uc002ifo.4; human. [Q71RG4-1]
DR CTD; 79089; -.
DR GeneCards; TMUB2; -.
DR HGNC; HGNC:28459; TMUB2.
DR HPA; ENSG00000168591; Low tissue specificity.
DR neXtProt; NX_Q71RG4; -.
DR OpenTargets; ENSG00000168591; -.
DR PharmGKB; PA145147917; -.
DR VEuPathDB; HostDB:ENSG00000168591; -.
DR eggNOG; ENOG502QU8U; Eukaryota.
DR GeneTree; ENSGT00390000014069; -.
DR HOGENOM; CLU_1488557_0_0_1; -.
DR InParanoid; Q71RG4; -.
DR OMA; QMKFIYQ; -.
DR OrthoDB; 1164744at2759; -.
DR PhylomeDB; Q71RG4; -.
DR TreeFam; TF329265; -.
DR PathwayCommons; Q71RG4; -.
DR SignaLink; Q71RG4; -.
DR BioGRID-ORCS; 79089; 17 hits in 1081 CRISPR screens.
DR ChiTaRS; TMUB2; human.
DR GeneWiki; TMUB2; -.
DR GenomeRNAi; 79089; -.
DR Pharos; Q71RG4; Tdark.
DR PRO; PR:Q71RG4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q71RG4; protein.
DR Bgee; ENSG00000168591; Expressed in granulocyte and 205 other tissues.
DR ExpressionAtlas; Q71RG4; baseline and differential.
DR Genevisible; Q71RG4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR InterPro; IPR040352; TMUB1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR14557; PTHR14557; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..321
FT /note="Transmembrane and ubiquitin-like domain-containing
FT protein 2"
FT /id="PRO_0000245312"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 174..247
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 87..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..20
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15498874, ECO:0000303|PubMed:17974005"
FT /id="VSP_019700"
FT VAR_SEQ 105..114
FT /note="GNDEKAEEAG -> ANTSLDKKAR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019701"
FT VAR_SEQ 115..321
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019702"
FT VAR_SEQ 201
FT /note="S -> R (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019703"
FT VAR_SEQ 202..321
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019704"
FT VARIANT 228
FT /note="R -> H (in dbSNP:rs9895154)"
FT /id="VAR_052695"
FT CONFLICT 265
FT /note="S -> R (in Ref. 5; CAD38755)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 33788 MW; C48656AD40A72454 CRC64;
MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV LAWLSTYVAD
SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP HPSEGNDEKA EEAGEGRGDS
TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA GSSSPEAPLR SEDSTCLPPS PGLITVRLKF
LNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC
HRSPPGSAVP GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA
TVSLVGVTVF FSFLVFGMYG R
