TM213_HUMAN
ID TM213_HUMAN Reviewed; 107 AA.
AC A2RRL7; A4D1R3; C9JH49; C9JX41; C9K0P0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Transmembrane protein 213;
DE Flags: Precursor;
GN Name=TMEM213;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A2RRL7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RRL7-2; Sequence=VSP_039555;
CC Name=3;
CC IsoId=A2RRL7-3; Sequence=VSP_039556;
CC Name=4;
CC IsoId=A2RRL7-4; Sequence=VSP_039557;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI31698.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC018663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24042.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83898.1; -; Genomic_DNA.
DR EMBL; BC131697; AAI31698.1; ALT_INIT; mRNA.
DR CCDS; CCDS47722.1; -. [A2RRL7-1]
DR RefSeq; NP_001078898.1; NM_001085429.1. [A2RRL7-1]
DR RefSeq; XP_005250224.1; XM_005250167.3.
DR AlphaFoldDB; A2RRL7; -.
DR SMR; A2RRL7; -.
DR BioGRID; 127567; 19.
DR IntAct; A2RRL7; 5.
DR STRING; 9606.ENSP00000390407; -.
DR PhosphoSitePlus; A2RRL7; -.
DR BioMuta; TMEM213; -.
DR PaxDb; A2RRL7; -.
DR PRIDE; A2RRL7; -.
DR ProteomicsDB; 472; -. [A2RRL7-1]
DR ProteomicsDB; 473; -. [A2RRL7-2]
DR ProteomicsDB; 474; -. [A2RRL7-3]
DR ProteomicsDB; 475; -. [A2RRL7-4]
DR Antibodypedia; 64747; 37 antibodies from 12 providers.
DR DNASU; 155006; -.
DR Ensembl; ENST00000397602.7; ENSP00000380727.3; ENSG00000214128.11. [A2RRL7-3]
DR Ensembl; ENST00000413208.1; ENSP00000401570.1; ENSG00000214128.11. [A2RRL7-4]
DR Ensembl; ENST00000442682.7; ENSP00000390407.2; ENSG00000214128.11. [A2RRL7-1]
DR Ensembl; ENST00000458494.1; ENSP00000393891.1; ENSG00000214128.11. [A2RRL7-2]
DR GeneID; 155006; -.
DR KEGG; hsa:155006; -.
DR MANE-Select; ENST00000442682.7; ENSP00000390407.2; NM_001085429.2; NP_001078898.1.
DR UCSC; uc010lna.5; human. [A2RRL7-1]
DR CTD; 155006; -.
DR DisGeNET; 155006; -.
DR GeneCards; TMEM213; -.
DR HGNC; HGNC:27220; TMEM213.
DR HPA; ENSG00000214128; Group enriched (kidney, salivary gland).
DR neXtProt; NX_A2RRL7; -.
DR OpenTargets; ENSG00000214128; -.
DR PharmGKB; PA162406494; -.
DR VEuPathDB; HostDB:ENSG00000214128; -.
DR eggNOG; ENOG502SA74; Eukaryota.
DR GeneTree; ENSGT00390000014153; -.
DR HOGENOM; CLU_143213_0_0_1; -.
DR InParanoid; A2RRL7; -.
DR OMA; LEQCANV; -.
DR OrthoDB; 1521865at2759; -.
DR PhylomeDB; A2RRL7; -.
DR TreeFam; TF336187; -.
DR PathwayCommons; A2RRL7; -.
DR SignaLink; A2RRL7; -.
DR BioGRID-ORCS; 155006; 11 hits in 1059 CRISPR screens.
DR ChiTaRS; TMEM213; human.
DR GenomeRNAi; 155006; -.
DR Pharos; A2RRL7; Tdark.
DR PRO; PR:A2RRL7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A2RRL7; protein.
DR Bgee; ENSG00000214128; Expressed in kidney epithelium and 77 other tissues.
DR Genevisible; A2RRL7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028121; TMEM213.
DR PANTHER; PTHR36293; PTHR36293; 1.
DR Pfam; PF15192; TMEM213; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..107
FT /note="Transmembrane protein 213"
FT /id="PRO_0000337054"
FT TOPO_DOM 28..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 28..52
FT /note="EASSSNSSSLTAHHPDPGTLEQCLN -> D (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039555"
FT VAR_SEQ 28
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039556"
FT VAR_SEQ 52..107
FT /note="NVDFCPQAARCCRTGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPK
FT DLQA -> RSGYLANLRGEADQLWKFCTVLCFWESRRSSSRIALMREAEEWPGWRSSVE
FT LVG (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_039557"
SQ SEQUENCE 107 AA; 11520 MW; BDE87C507C11E0D3 CRC64;
MQRLPAATRA TLILSLAFAS LHSACSAEAS SSNSSSLTAH HPDPGTLEQC LNVDFCPQAA
RCCRTGVDEY GWIAAAVGWS LWFLTLILLC VDKLMKLTPD EPKDLQA
