ID   TIM16_XENTR             Reviewed;         125 AA.
AC   Q5XGJ0; Q28G77;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit tim16;
DE   AltName: Full=Presequence translocated-associated motor subunit pam16;
GN   Name=pam16; Synonyms=tim16, timm16; ORFNames=TGas144p19.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates ATP-dependent protein translocation into the
CC       mitochondrial matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC       mitochondrial HSP70 protein, GRPE, TIMM44, TIMM16/PAM16 and TIMM14.
CC       Associates with the TIM23 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- DOMAIN: The J-like region, although related to the J domain does not
CC       have co-chaperone activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIM16/PAM16 family. {ECO:0000305}.
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DR   EMBL; CR761515; CAJ83958.1; -; mRNA.
DR   EMBL; BC084449; AAH84449.1; -; mRNA.
DR   RefSeq; NP_001004771.1; NM_001004771.2.
DR   AlphaFoldDB; Q5XGJ0; -.
DR   SMR; Q5XGJ0; -.
DR   STRING; 8364.ENSXETP00000037687; -.
DR   DNASU; 447952; -.
DR   GeneID; 447952; -.
DR   KEGG; xtr:447952; -.
DR   CTD; 51025; -.
DR   Xenbase; XB-GENE-6454649; pam16.
DR   InParanoid; Q5XGJ0; -.
DR   OrthoDB; 1640138at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR005341; Tim16.
DR   PANTHER; PTHR12388; PTHR12388; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..125
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit tim16"
FT                   /id="PRO_0000214084"
FT   REGION          58..110
FT                   /note="J-like"
FT   REGION          105..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   125 AA;  13897 MW;  ECB7265C6D1639EE CRC64;
     MAKYLAQIMV MGMQVVGRAF TRALRQEFAA SRAAAEARGR AGTESAAVSS LSGISLQEAQ
     QILNVSKLTP EEIQKNYEHL FKVNDKEVGG SFYLQSKVVR AKERLDQEMD IQSKTEKPKD
     ETTQT