ID   BSHC_ALKCK              Reviewed;         540 AA.
AC   Q5WFF9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=ABC2366;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; AP006627; BAD64901.1; -; Genomic_DNA.
DR   RefSeq; WP_011247209.1; NC_006582.1.
DR   AlphaFoldDB; Q5WFF9; -.
DR   SMR; Q5WFF9; -.
DR   STRING; 66692.ABC2366; -.
DR   EnsemblBacteria; BAD64901; BAD64901; ABC2366.
DR   KEGG; bcl:ABC2366; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..540
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378217"
FT   COILED          457..477
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   540 AA;  62104 MW;  1097A3BE073F5840 CRC64;
     MRFEALDTRR LTGFLAEYVN QPDQCSDLFS YRWKTNGWEQ ERSEDLAKRS FSHRQALCRL
     LEARHAPLRK REACMDNIHK LKQENALVVV AGQQAGLMTG PLYTAYKAMS VILLAKQYEA
     TLNQPVVPLF WIAGEDHDLD EVRYVHYLKG DMWKKLMLGD EPNGEAASTK VLPKKELDTF
     LAKLFASLPE TSYTNTLKAM VTQAAATAGT YTEFFKLLMH ELFYREGLLF LDSNDPELRA
     IERPFFKQLI RKVDALQECQ AAGEARFVEK GYPSPIATEK QNAHLFYTLD GKRRRLDYEA
     GRFYVRETER QFTKEELLAE VDSHPQRFSN NVVTRPLMQE WLLPTLAFVA GPGELAYWAT
     LKDVFALFDY KLTPIIPRLS ATFVPCRVEK HLRERKEAAE TYILGEGEKL KEAWLASQHS
     YPVAQRAQAA AEAIEAAHLP FRELAGEISP TLKKMGEKNR AFIQGQIAFL KERMEREIRE
     QHQVGLSKYD EAMTWLHPKD APQERILHSF ILLNTAGIDI FSRLLEKKPP HTGAHLVFYV