BSDC1_MOUSE
ID BSDC1_MOUSE Reviewed; 427 AA.
AC Q80Y55; B2KGE2; Q8BI04; Q8VDP1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=BSD domain-containing protein 1;
GN Name=Bsdc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NOD;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21480.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK037201; BAC29751.1; -; mRNA.
DR EMBL; AK144053; BAE25672.1; -; mRNA.
DR EMBL; CU302431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466552; EDL30194.1; -; Genomic_DNA.
DR EMBL; BC021480; AAH21480.1; ALT_INIT; mRNA.
DR EMBL; BC049111; AAH49111.1; -; mRNA.
DR CCDS; CCDS18692.1; -.
DR RefSeq; NP_598650.2; NM_133889.2.
DR AlphaFoldDB; Q80Y55; -.
DR BioGRID; 221441; 7.
DR IntAct; Q80Y55; 7.
DR STRING; 10090.ENSMUSP00000048742; -.
DR iPTMnet; Q80Y55; -.
DR PhosphoSitePlus; Q80Y55; -.
DR EPD; Q80Y55; -.
DR jPOST; Q80Y55; -.
DR MaxQB; Q80Y55; -.
DR PaxDb; Q80Y55; -.
DR PeptideAtlas; Q80Y55; -.
DR PRIDE; Q80Y55; -.
DR ProteomicsDB; 273802; -.
DR Antibodypedia; 16954; 120 antibodies from 20 providers.
DR DNASU; 100383; -.
DR Ensembl; ENSMUST00000048162; ENSMUSP00000048742; ENSMUSG00000040859.
DR GeneID; 100383; -.
DR KEGG; mmu:100383; -.
DR UCSC; uc008uxb.1; mouse.
DR CTD; 55108; -.
DR MGI; MGI:1913466; Bsdc1.
DR VEuPathDB; HostDB:ENSMUSG00000040859; -.
DR eggNOG; KOG2690; Eukaryota.
DR GeneTree; ENSGT00390000009361; -.
DR HOGENOM; CLU_053864_0_0_1; -.
DR InParanoid; Q80Y55; -.
DR OMA; PCANVKF; -.
DR OrthoDB; 787655at2759; -.
DR PhylomeDB; Q80Y55; -.
DR TreeFam; TF313210; -.
DR BioGRID-ORCS; 100383; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Bsdc1; mouse.
DR PRO; PR:Q80Y55; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80Y55; protein.
DR Bgee; ENSMUSG00000040859; Expressed in embryonic brain and 254 other tissues.
DR ExpressionAtlas; Q80Y55; baseline and differential.
DR Genevisible; Q80Y55; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.10.3970.10; -; 1.
DR InterPro; IPR005607; BSD_dom.
DR InterPro; IPR035925; BSD_dom_sf.
DR Pfam; PF03909; BSD; 1.
DR SMART; SM00751; BSD; 1.
DR SUPFAM; SSF140383; SSF140383; 1.
DR PROSITE; PS50858; BSD; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..427
FT /note="BSD domain-containing protein 1"
FT /id="PRO_0000282640"
FT DOMAIN 146..198
FT /note="BSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00036"
FT REGION 208..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..343
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW68"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW68"
FT MOD_RES 353
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW68"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW68"
FT MOD_RES 415
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NW68"
FT CONFLICT 338
FT /note="G -> S (in Ref. 4; AAH21480)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="D -> G (in Ref. 1; BAC29751)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 427 AA; 46953 MW; 0261E1E9AFBB2BA1 CRC64;
MAEGEDVGWW RSWLQQSYQA VKEKSTEALE FMKRDLTEFT QVVQHDTACT IAATASVVKE
KLATEGSSGA TEKVKKGLSD FLGVISDTFA PSPDKTIDCD VITLMGTPSG TAEPYDGTKA
RLYSLQSDPA TYCNEPDGPP ELFDAWLSEF CLEEKKGEIS ELLVGSPSIR ALYTKMVPAA
VSHSEFWHRY FYKVHQLEQE QARRDALKQR ADQSISEEPG WEEEEEELEG IVPSPKEAKI
PKETKTTTSP EDEPAPQSPC EETPVEPPAE ATPSESSESI SLVTQVANPA AAPEAPELPK
DLSQKLFEAS LEEQSLAEDE GETGPPPPPP SKPLTPAGRA SGPEPRPPAR VETLREEVPT
DLRVFELNSD SGKSTPSNNG KKGSSTDISE DWEKDFDLDM TEEEVQMALS KVDASGELED
VEWEDWE
