TIGD2_HUMAN
ID TIGD2_HUMAN Reviewed; 525 AA.
AC Q4W5G0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Tigger transposable element-derived protein 2;
GN Name=TIGD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000255|PROSITE-ProRule:PRU00583}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
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DR EMBL; AC104785; AAY40951.1; -; Genomic_DNA.
DR CCDS; CCDS3633.1; -.
DR RefSeq; NP_663761.1; NM_145715.2.
DR AlphaFoldDB; Q4W5G0; -.
DR SMR; Q4W5G0; -.
DR BioGRID; 127935; 3.
DR IntAct; Q4W5G0; 1.
DR STRING; 9606.ENSP00000317170; -.
DR iPTMnet; Q4W5G0; -.
DR PhosphoSitePlus; Q4W5G0; -.
DR BioMuta; TIGD2; -.
DR DMDM; 74754171; -.
DR EPD; Q4W5G0; -.
DR jPOST; Q4W5G0; -.
DR MassIVE; Q4W5G0; -.
DR PaxDb; Q4W5G0; -.
DR PeptideAtlas; Q4W5G0; -.
DR PRIDE; Q4W5G0; -.
DR ProteomicsDB; 62372; -.
DR Antibodypedia; 65566; 19 antibodies from 10 providers.
DR DNASU; 166815; -.
DR Ensembl; ENST00000603357.3; ENSP00000486687.1; ENSG00000180346.5.
DR GeneID; 166815; -.
DR KEGG; hsa:166815; -.
DR MANE-Select; ENST00000603357.3; ENSP00000486687.1; NM_145715.3; NP_663761.1.
DR CTD; 166815; -.
DR GeneCards; TIGD2; -.
DR HGNC; HGNC:18333; TIGD2.
DR HPA; ENSG00000180346; Tissue enhanced (liver).
DR MIM; 612973; gene.
DR neXtProt; NX_Q4W5G0; -.
DR OpenTargets; ENSG00000180346; -.
DR PharmGKB; PA38526; -.
DR VEuPathDB; HostDB:ENSG00000180346; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000162273; -.
DR InParanoid; Q4W5G0; -.
DR OMA; QWFDSQS; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q4W5G0; -.
DR TreeFam; TF101131; -.
DR PathwayCommons; Q4W5G0; -.
DR SignaLink; Q4W5G0; -.
DR BioGRID-ORCS; 166815; 13 hits in 1075 CRISPR screens.
DR GenomeRNAi; 166815; -.
DR Pharos; Q4W5G0; Tdark.
DR PRO; PR:Q4W5G0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q4W5G0; protein.
DR Bgee; ENSG00000180346; Expressed in amniotic fluid and 158 other tissues.
DR ExpressionAtlas; Q4W5G0; baseline and differential.
DR Genevisible; Q4W5G0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..525
FT /note="Tigger transposable element-derived protein 2"
FT /id="PRO_0000271088"
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 67..139
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 168..385
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 100..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 442..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 475
FT /note="H -> R (in dbSNP:rs2280099)"
FT /id="VAR_053036"
SQ SEQUENCE 525 AA; 59623 MW; 5FD2A8B1765D1001 CRC64;
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE RIINYANSSD
PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQAKFFF DALGMEGDFN
ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AAREFCGSFQ EFVEKENLQP EQIYGADQTG
LFWKCLPSRT LTLETDQSTS GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT
DLSNLPVTYY SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG NDPKIFWKNL
TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI DEGAILAANL ATVLQNTEEC
EHVDIENIDQ WFDSRSSDSS CQVLTDSESA EDQTKAAEQK PSSKSRKTEL NPEKHISHKA
ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRKKQKIQ NNKNH
