TF3C3_HUMAN
ID TF3C3_HUMAN Reviewed; 886 AA.
AC Q9Y5Q9; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 192.
DE RecName: Full=General transcription factor 3C polypeptide 3;
DE AltName: Full=Transcription factor IIIC 102 kDa subunit;
DE Short=TFIIIC 102 kDa subunit;
DE Short=TFIIIC102;
DE AltName: Full=Transcription factor IIIC subunit gamma;
DE Short=TF3C-gamma;
GN Name=GTF3C3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH BRF1 AND TBP, AND
RP IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
RX PubMed=10373544; DOI=10.1128/mcb.19.7.4944;
RA Hsieh Y.-J., Wang Z., Kovelman R., Roeder R.G.;
RT "Cloning and characterization of two evolutionarily conserved subunits
RT (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in
RT functional interactions with TFIIIB and RNA polymerase III.";
RL Mol. Cell. Biol. 19:4944-4952(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Hegde R., Alnemri E.;
RT "Identification of a short isoform of hTFIIIC102 subunit.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hepatoma, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-70.
RC TISSUE=Bone marrow, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-886 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-282, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Involved in RNA polymerase III-mediated transcription.
CC Integral, tightly associated component of the DNA-binding TFIIIC2
CC subcomplex that directly binds tRNA and virus-associated RNA promoters.
CC -!- SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six
CC subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts
CC with BRF1 and TBP. {ECO:0000269|PubMed:10373544}.
CC -!- INTERACTION:
CC Q9Y5Q9; P13928: ANXA8; NbExp=3; IntAct=EBI-1054873, EBI-2556915;
CC Q9Y5Q9; P05067: APP; NbExp=3; IntAct=EBI-1054873, EBI-77613;
CC Q9Y5Q9; Q6XD76: ASCL4; NbExp=3; IntAct=EBI-1054873, EBI-10254793;
CC Q9Y5Q9; Q9H7T9: AUNIP; NbExp=3; IntAct=EBI-1054873, EBI-10693257;
CC Q9Y5Q9; P46379-2: BAG6; NbExp=3; IntAct=EBI-1054873, EBI-10988864;
CC Q9Y5Q9; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-1054873, EBI-742750;
CC Q9Y5Q9; Q5H9J7: BEX5; NbExp=3; IntAct=EBI-1054873, EBI-10243741;
CC Q9Y5Q9; Q96LL4: C8orf48; NbExp=3; IntAct=EBI-1054873, EBI-751596;
CC Q9Y5Q9; Q13191: CBLB; NbExp=3; IntAct=EBI-1054873, EBI-744027;
CC Q9Y5Q9; Q14781-2: CBX2; NbExp=3; IntAct=EBI-1054873, EBI-11974585;
CC Q9Y5Q9; Q494V2-2: CFAP100; NbExp=3; IntAct=EBI-1054873, EBI-11953200;
CC Q9Y5Q9; P48730-2: CSNK1D; NbExp=3; IntAct=EBI-1054873, EBI-9087876;
CC Q9Y5Q9; Q5TAQ9-2: DCAF8; NbExp=3; IntAct=EBI-1054873, EBI-25842815;
CC Q9Y5Q9; Q92782-2: DPF1; NbExp=3; IntAct=EBI-1054873, EBI-23669343;
CC Q9Y5Q9; Q86TI2-2: DPP9; NbExp=3; IntAct=EBI-1054873, EBI-21529239;
CC Q9Y5Q9; Q6P1L5: FAM117B; NbExp=3; IntAct=EBI-1054873, EBI-3893327;
CC Q9Y5Q9; Q17RN3: FAM98C; NbExp=3; IntAct=EBI-1054873, EBI-5461838;
CC Q9Y5Q9; Q96IJ6: GMPPA; NbExp=3; IntAct=EBI-1054873, EBI-750953;
CC Q9Y5Q9; Q9HBQ8: GOLGA2P5; NbExp=3; IntAct=EBI-1054873, EBI-22000587;
CC Q9Y5Q9; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-1054873, EBI-347538;
CC Q9Y5Q9; Q6NXT2: H3-5; NbExp=3; IntAct=EBI-1054873, EBI-2868501;
CC Q9Y5Q9; Q9HCC6: HES4; NbExp=3; IntAct=EBI-1054873, EBI-2680288;
CC Q9Y5Q9; P42858: HTT; NbExp=12; IntAct=EBI-1054873, EBI-466029;
CC Q9Y5Q9; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-1054873, EBI-2796400;
CC Q9Y5Q9; Q92615: LARP4B; NbExp=3; IntAct=EBI-1054873, EBI-1052558;
CC Q9Y5Q9; A2RU56: LOC401296; NbExp=3; IntAct=EBI-1054873, EBI-9088215;
CC Q9Y5Q9; Q14693: LPIN1; NbExp=3; IntAct=EBI-1054873, EBI-5278370;
CC Q9Y5Q9; Q8TD91-2: MAGEC3; NbExp=3; IntAct=EBI-1054873, EBI-10694180;
CC Q9Y5Q9; Q9H000: MKRN2; NbExp=3; IntAct=EBI-1054873, EBI-2341005;
CC Q9Y5Q9; Q15049: MLC1; NbExp=3; IntAct=EBI-1054873, EBI-8475277;
CC Q9Y5Q9; O95563: MPC2; NbExp=3; IntAct=EBI-1054873, EBI-719403;
CC Q9Y5Q9; P01106: MYC; NbExp=4; IntAct=EBI-1054873, EBI-447544;
CC Q9Y5Q9; O15381-5: NVL; NbExp=3; IntAct=EBI-1054873, EBI-18577082;
CC Q9Y5Q9; Q8N7B6-2: PACRGL; NbExp=3; IntAct=EBI-1054873, EBI-10694433;
CC Q9Y5Q9; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-1054873, EBI-10302990;
CC Q9Y5Q9; Q96FM1: PGAP3; NbExp=3; IntAct=EBI-1054873, EBI-22113571;
CC Q9Y5Q9; P19388: POLR2E; NbExp=3; IntAct=EBI-1054873, EBI-395189;
CC Q9Y5Q9; Q13332-6: PTPRS; NbExp=3; IntAct=EBI-1054873, EBI-25906956;
CC Q9Y5Q9; Q9Y5P3: RAI2; NbExp=3; IntAct=EBI-1054873, EBI-746228;
CC Q9Y5Q9; Q96D59: RNF183; NbExp=3; IntAct=EBI-1054873, EBI-743938;
CC Q9Y5Q9; Q969K3: RNF34; NbExp=3; IntAct=EBI-1054873, EBI-2340642;
CC Q9Y5Q9; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-1054873, EBI-366570;
CC Q9Y5Q9; P62701: RPS4X; NbExp=3; IntAct=EBI-1054873, EBI-354303;
CC Q9Y5Q9; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-1054873, EBI-6257312;
CC Q9Y5Q9; Q8N488: RYBP; NbExp=3; IntAct=EBI-1054873, EBI-752324;
CC Q9Y5Q9; O75446: SAP30; NbExp=3; IntAct=EBI-1054873, EBI-632609;
CC Q9Y5Q9; P60896: SEM1; NbExp=3; IntAct=EBI-1054873, EBI-79819;
CC Q9Y5Q9; Q8NHS9: SPATA22; NbExp=3; IntAct=EBI-1054873, EBI-7067260;
CC Q9Y5Q9; Q8TCT7-2: SPPL2B; NbExp=3; IntAct=EBI-1054873, EBI-8345366;
CC Q9Y5Q9; Q9NRL3: STRN4; NbExp=3; IntAct=EBI-1054873, EBI-717245;
CC Q9Y5Q9; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-1054873, EBI-747797;
CC Q9Y5Q9; O43615: TIMM44; NbExp=3; IntAct=EBI-1054873, EBI-861737;
CC Q9Y5Q9; O75604-3: USP2; NbExp=3; IntAct=EBI-1054873, EBI-10696113;
CC Q9Y5Q9; P40337-2: VHL; NbExp=3; IntAct=EBI-1054873, EBI-12157263;
CC Q9Y5Q9; P58304: VSX2; NbExp=3; IntAct=EBI-1054873, EBI-6427899;
CC Q9Y5Q9; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-1054873, EBI-14104088;
CC Q9Y5Q9; Q96MN9-2: ZNF488; NbExp=3; IntAct=EBI-1054873, EBI-25831733;
CC Q9Y5Q9; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-1054873, EBI-745520;
CC Q9Y5Q9; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-1054873, EBI-18036029;
CC Q9Y5Q9; Q8NBB4-2: ZSCAN1; NbExp=3; IntAct=EBI-1054873, EBI-12021938;
CC Q9Y5Q9; P10073: ZSCAN22; NbExp=3; IntAct=EBI-1054873, EBI-10178224;
CC Q9Y5Q9; A0A384ME25; NbExp=3; IntAct=EBI-1054873, EBI-10211777;
CC Q9Y5Q9; Q9H669; NbExp=3; IntAct=EBI-1054873, EBI-10307430;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5Q9-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5Q9-2; Sequence=VSP_010353, VSP_010354;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF133123; AAD41475.1; -; mRNA.
DR EMBL; AF465407; AAL73493.1; -; mRNA.
DR EMBL; AK027050; BAB15638.1; ALT_INIT; mRNA.
DR EMBL; AK314718; BAG37262.1; -; mRNA.
DR EMBL; AC012486; AAX88853.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70132.1; -; Genomic_DNA.
DR EMBL; BC015995; AAH15995.1; -; mRNA.
DR EMBL; BC043347; AAH43347.1; -; mRNA.
DR EMBL; AL137453; CAB70745.1; -; mRNA.
DR CCDS; CCDS2316.1; -. [Q9Y5Q9-1]
DR CCDS; CCDS56153.1; -. [Q9Y5Q9-2]
DR PIR; T46268; T46268.
DR RefSeq; NP_001193703.1; NM_001206774.1. [Q9Y5Q9-2]
DR RefSeq; NP_036218.1; NM_012086.4. [Q9Y5Q9-1]
DR AlphaFoldDB; Q9Y5Q9; -.
DR SMR; Q9Y5Q9; -.
DR BioGRID; 114739; 171.
DR CORUM; Q9Y5Q9; -.
DR IntAct; Q9Y5Q9; 127.
DR MINT; Q9Y5Q9; -.
DR STRING; 9606.ENSP00000263956; -.
DR GlyGen; Q9Y5Q9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y5Q9; -.
DR MetOSite; Q9Y5Q9; -.
DR PhosphoSitePlus; Q9Y5Q9; -.
DR BioMuta; GTF3C3; -.
DR DMDM; 47606223; -.
DR EPD; Q9Y5Q9; -.
DR jPOST; Q9Y5Q9; -.
DR MassIVE; Q9Y5Q9; -.
DR MaxQB; Q9Y5Q9; -.
DR PaxDb; Q9Y5Q9; -.
DR PeptideAtlas; Q9Y5Q9; -.
DR PRIDE; Q9Y5Q9; -.
DR ProteomicsDB; 86478; -. [Q9Y5Q9-1]
DR ProteomicsDB; 86479; -. [Q9Y5Q9-2]
DR Antibodypedia; 19878; 253 antibodies from 27 providers.
DR DNASU; 9330; -.
DR Ensembl; ENST00000263956.8; ENSP00000263956.3; ENSG00000119041.11. [Q9Y5Q9-1]
DR Ensembl; ENST00000409364.3; ENSP00000386465.3; ENSG00000119041.11. [Q9Y5Q9-2]
DR GeneID; 9330; -.
DR KEGG; hsa:9330; -.
DR MANE-Select; ENST00000263956.8; ENSP00000263956.3; NM_012086.5; NP_036218.1.
DR UCSC; uc002uts.4; human. [Q9Y5Q9-1]
DR CTD; 9330; -.
DR DisGeNET; 9330; -.
DR GeneCards; GTF3C3; -.
DR HGNC; HGNC:4666; GTF3C3.
DR HPA; ENSG00000119041; Low tissue specificity.
DR MIM; 604888; gene.
DR neXtProt; NX_Q9Y5Q9; -.
DR OpenTargets; ENSG00000119041; -.
DR PharmGKB; PA29054; -.
DR VEuPathDB; HostDB:ENSG00000119041; -.
DR eggNOG; KOG2076; Eukaryota.
DR GeneTree; ENSGT00390000016929; -.
DR HOGENOM; CLU_002391_1_1_1; -.
DR InParanoid; Q9Y5Q9; -.
DR OMA; HEVAFNL; -.
DR OrthoDB; 271586at2759; -.
DR PhylomeDB; Q9Y5Q9; -.
DR TreeFam; TF105955; -.
DR PathwayCommons; Q9Y5Q9; -.
DR Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR Reactome; R-HSA-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-HSA-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR SignaLink; Q9Y5Q9; -.
DR SIGNOR; Q9Y5Q9; -.
DR BioGRID-ORCS; 9330; 401 hits in 1091 CRISPR screens.
DR ChiTaRS; GTF3C3; human.
DR GenomeRNAi; 9330; -.
DR Pharos; Q9Y5Q9; Tdark.
DR PRO; PR:Q9Y5Q9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9Y5Q9; protein.
DR Bgee; ENSG00000119041; Expressed in calcaneal tendon and 188 other tissues.
DR ExpressionAtlas; Q9Y5Q9; baseline and differential.
DR Genevisible; Q9Y5Q9; HS.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; IDA:HGNC-UCL.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IDA:GO_Central.
DR GO; GO:0042791; P:5S class rRNA transcription by RNA polymerase III; IC:HGNC-UCL.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IBA:GO_Central.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IC:HGNC-UCL.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR039340; Tfc4/TFIIIC-102/Sfc4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23082; PTHR23082; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; TPR repeat; Transcription.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..886
FT /note="General transcription factor 3C polypeptide 3"
FT /id="PRO_0000106363"
FT REPEAT 149..182
FT /note="TPR 1"
FT REPEAT 183..216
FT /note="TPR 2"
FT REPEAT 217..250
FT /note="TPR 3"
FT REPEAT 252..284
FT /note="TPR 4"
FT REPEAT 290..323
FT /note="TPR 5"
FT REPEAT 326..361
FT /note="TPR 6"
FT REPEAT 421..454
FT /note="TPR 7"
FT REPEAT 456..489
FT /note="TPR 8"
FT REPEAT 491..523
FT /note="TPR 9"
FT REPEAT 733..766
FT /note="TPR 10"
FT REPEAT 811..844
FT /note="TPR 11"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..115
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 282
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 407..413
FT /note="PLLTTLV -> VCNKICT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_010353"
FT VAR_SEQ 414..886
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_010354"
FT VARIANT 70
FT /note="N -> S (in dbSNP:rs11559078)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_061902"
FT CONFLICT 412..413
FT /note="LV -> HL (in Ref. 6; AAH15995)"
FT /evidence="ECO:0000305"
FT CONFLICT 589
FT /note="I -> M (in Ref. 3; BAB15638)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 886 AA; 101272 MW; 9B97269929F9765F CRC64;
MSGFSPELID YLEGKISFEE FERRREERKT REKKSLQEKG KLSAEENPDD SEVPSSSGIN
STKSQDKDVN EGETSDGVRK SVHKVFASML GENEDDEEEE EEEEEEEEEE ETPEQPTAGD
VFVLEMVLNR ETKKMMKEKR PRSKLPRALR GLMGEANIRF ARGEREEAIL MCMEIIRQAP
LAYEPFSTLA MIYEDQGDME KSLQFELIAA HLNPSDTEEW VRLAEMSLEQ DNIKQAIFCY
TKALKYEPTN VRYLWERSSL YEQMGDHKMA MDGYRRILNL LSPSDGERFM QLARDMAKSY
YEANDVTSAI NIIDEAFSKH QGLVSMEDVN IAAELYISNK QYDKALEIIT DFSGIVLEKK
TSEEGTSEEN KAPENVTCTI PDGVPIDITV KLMVCLVHLN ILEPLNPLLT TLVEQNPEDM
GDLYLDVAEA FLDVGEYNSA LPLLSALVCS ERYNLAVVWL RHAECLKALG YMERAAESYG
KVVDLAPLHL DARISLSTLQ QQLGQPEKAL EALEPMYDPD TLAQDANAAQ QELKLLLHRS
TLLFSQGKMY GYVDTLLTML AMLLKVAMNR AQVCLISSSK SGERHLYLIK VSRDKISDSN
DQESANCDAK AIFAVLTSVL TKDDWWNLLL KAIYSLCDLS RFQEAELLVD SSLEYYSFYD
DRQKRKELEY FGLSAAILDK NFRKAYNYIR IMVMENVNKP QLWNIFNQVT MHSQDVRHHR
FCLRLMLKNP ENHALCVLNG HNAFVSGSFK HALGQYVQAF RTHPDEPLYS FCIGLTFIHM
ASQKYVLRRH ALIVQGFSFL NRYLSLRGPC QESFYNLGRG LHQLGLIHLA IHYYQKALEL
PPLVVEGIEL DQLDLRRDIA YNLSLIYQSS GNTGMAQTLL YTYCSI
