TF2B2_SACS2
ID TF2B2_SACS2 Reviewed; 293 AA.
AC P58110;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transcription initiation factor IIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
DE Short=TFIIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
GN Name=tfbB {ECO:0000255|HAMAP-Rule:MF_00383}; Synonyms=tfb-2;
GN OrderedLocusNames=SSO0946; ORFNames=C33_019;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN [2]
RP INDUCTION BY VIRUS (MICROBIAL INFECTION).
RC STRAIN=2-2-12;
RX PubMed=18337566; DOI=10.1128/jvi.02583-07;
RA Ortmann A.C., Brumfield S.K., Walther J., McInnerney K., Brouns S.J.,
RA van de Werken H.J., Bothner B., Douglas T., van de Oost J., Young M.J.;
RT "Transcriptome analysis of infection of the archaeon Sulfolobus
RT solfataricus with Sulfolobus turreted icosahedral virus.";
RL J. Virol. 82:4874-4883(2008).
CC -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC responsible for recruiting RNA polymerase II to the pre-initiation
CC complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC -!- INDUCTION: (Microbial infection) At least 4-fold induced following
CC infection by Sulfolobus turreted icosahedral virus 1 (STIV-1) in strain
CC 2-2-12. {ECO:0000269|PubMed:18337566}.
CC -!- MISCELLANEOUS: Strain 2-2-12 is a substrain of P2 that is highly
CC susceptible to infection by Sulfolobus turreted icosahedral virus 1
CC (STIV-1). {ECO:0000269|PubMed:18337566}.
CC -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC Rule:MF_00383}.
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DR EMBL; AE006641; AAK41221.1; -; Genomic_DNA.
DR PIR; F90245; F90245.
DR RefSeq; WP_009992381.1; NC_002754.1.
DR AlphaFoldDB; P58110; -.
DR SMR; P58110; -.
DR STRING; 273057.SSO0946; -.
DR EnsemblBacteria; AAK41221; AAK41221; SSO0946.
DR GeneID; 44129874; -.
DR KEGG; sso:SSO0946; -.
DR PATRIC; fig|273057.12.peg.941; -.
DR eggNOG; arCOG01981; Archaea.
DR HOGENOM; CLU_043736_0_1_2; -.
DR InParanoid; P58110; -.
DR OMA; NEYVCTR; -.
DR PhylomeDB; P58110; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 2.
DR HAMAP; MF_00383; TF2B_arch; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023484; TFIIB_arc.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618; PTHR11618; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS51134; ZF_TFIIB; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..293
FT /note="Transcription initiation factor IIB 2"
FT /id="PRO_0000119336"
FT REPEAT 107..193
FT /note="1"
FT REPEAT 204..285
FT /note="2"
FT ZN_FING 1..31
FT /note="TFIIB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 3
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 6
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ SEQUENCE 293 AA; 33284 MW; F9F4B5F0D64085F7 CRC64;
MKCPYCKTDN AITYDVEKGM YVCTNCASVI EDSAVDPGPD WRAYNAKDRN EKERVGSPST
PKVHDWGFHT IIGYGRAKDR LKTLKMQRMQ NKIRVSPKDK KLVTLLSILN DESSKLELPE
HVKETASLII RKMVETGLTK RIDQYTLIVA ALYYSCQVNN IPRHLQEFKV RYSISSSEFW
SALKRVQYVA NSIPGFRPKI KPAEYIPKIL YKLNLPPIIG TKASELVDLM HKQGLTSGKG
YLSLSAASVY LISALMDIKK TQKEVADSLD ITEVTIRNRY KDIVDNFDIV VTL
