ID   BRCA2_DROSE             Reviewed;         938 AA.
AC   B4IH30;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Breast cancer type 2 susceptibility protein homolog {ECO:0000250|UniProtKB:Q9W157};
GN   Name=Brca2 {ECO:0000250|UniProtKB:Q9W157}; ORFNames=GM11870;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW49206.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW49206.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in and required for double-strand break repair by
CC       meiotic and mitotic homologous recombination. During meiosis, has a
CC       dual role in the repair of meiotic double-stranded breaks and the
CC       efficient activation of the meiotic recombination checkpoint (By
CC       similarity). {ECO:0000250|UniProtKB:Q9W157}.
CC   -!- SUBUNIT: Interacts with Rad9 and spn-A/Rad51.
CC       {ECO:0000250|UniProtKB:Q9W157}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9W157}.
CC       Note=Brca2 and spn-A become recruited to nuclear foci after DNA damage.
CC       {ECO:0000250|UniProtKB:Q9W157}.
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DR   EMBL; CH480838; EDW49206.1; -; Genomic_DNA.
DR   RefSeq; XP_002043075.1; XM_002043039.1.
DR   AlphaFoldDB; B4IH30; -.
DR   STRING; 7238.B4IH30; -.
DR   EnsemblMetazoa; FBtr0194855; FBpp0193347; FBgn0166811.
DR   HOGENOM; CLU_315529_0_0_1; -.
DR   OMA; ECFSEDM; -.
DR   PhylomeDB; B4IH30; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043150; P:DNA synthesis involved in double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0010778; P:meiotic DNA repair synthesis involved in reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:1901563; P:response to camptothecin; IEA:EnsemblMetazoa.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   PROSITE; PS50138; BRCA2_REPEAT; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA damage; DNA repair; Meiosis; Mitosis;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..938
FT                   /note="Breast cancer type 2 susceptibility protein homolog"
FT                   /id="PRO_0000392917"
FT   REPEAT          537..571
FT                   /note="BRCA2 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          638..672
FT                   /note="BRCA2 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          713..747
FT                   /note="BRCA2 3"
FT                   /evidence="ECO:0000255"
FT   REGION          320..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          870..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        871..899
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..914
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   938 AA;  105452 MW;  44752C1FC133C19E CRC64;
     MDQKGASGSR PNRLSQGKEA YACERSATVS VAANRNNIIN EMAKICEADR QTSAIARRTQ
     VHERLAVANS DFVAVEDLIL AYAEPTPEDQ VEMIMRDFCS SPTYEEDEDE PSFESEPWFR
     FRNKRIRTYS RKRDPRSYMA VRTEKPRGTS GLSVQRDLNT SFTSMACDFD AASSQKIHEV
     LLNLSQYFSA TAKTSSPTPV PSQIDLPTEA RQDSGKECFN AEVENLRDDL LQNGFTFEAS
     IYDNEHEQEG SEKFNVCSDA EIAEHKKLLK GPTQAEHVGK EENPNFILEG IPLSEWLTPM
     EPPMISKDVI KNIPDKKVKL EPSFQKEQKS SKDSNESKIR APSKPSCDIT EKNEGTTVLD
     QPYAAQQENL SNDGDLLEEF LFNEWHPMQC SNGPSTSNDA IQVPKEEINS IKRTDEEQPE
     KETPNKSRST SSHQLSFRKT SLKFIEISEE MKIKGEKFVD KVISGLYHPS HKCNLRTEEY
     SDNHSQVMES TQCVEFKSAL NKPIELLDKK ETYDMLAKVE VGEINGKCSP LNNEAIAEPE
     FCGFRTASNK AIPISEKMKI KTAEFMAEFQ YKETNHQNDY LVNQPNDNST SVGLDTVLKK
     SIEISEEMPT KASKLVVVDT RLGEPHQPTL DPVCSDLNEP QFFGFRTASK KAIEITEAME
     KRGAMFLAQS RATDQQAEWQ PSDFPDIPHT SPKNEIHSIN VENNKAVHTK TASETEFFGF
     RTASNKGIVI SENTKMKVAQ FMSEFQAADA STDSNKPIVI SEEPSNIAAK FVDEAAAEDS
     PSKSTFCNVQ SQENPLNIEH FKHDLFVKRS AKEEHPLCSQ PLVRTPRRSL EIHSSLSQLA
     GQSPLDQATK KSVIARRNLL SLKRKRKIVS STETSTSCAS PDMERFAPKP SSTSTPLADR
     DLNRSKDCAK NRQDAEDMSP ICMQPKKSRR LGLSRSRY