ID   TEG7_VZVO               Reviewed;         259 AA.
AC   Q4JQW8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   02-DEC-2020, entry version 27.
DE   RecName: Full=Tegument protein UL51 homolog;
DE   AltName: Full=Protein ORF7;
GN   ORFNames=ORF7;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28356523; DOI=10.1128/jvi.00127-17;
RA   Jiang H.F., Wang W., Jiang X., Zeng W.B., Shen Z.Z., Song Y.G., Yang H.,
RA   Liu X.J., Dong X., Zhou J., Sun J.Y., Yu F.L., Guo L., Cheng T., Rayner S.,
RA   Zhao F., Zhu H., Luo M.H.;
RT   "ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic
RT   Envelopment in Differentiated Neuronal Cells.";
RL   J. Virol. 91:0-0(2017).
RN   [4]
RP   FUNCTION, INTERACTION WITH PROTEIN ORF53, AND SUBCELLULAR LOCATION.
RX   PubMed=29116592; DOI=10.1007/s12250-017-4048-x;
RA   Wang W., Fu W., Pan D., Cai L., Ye J., Liu J., Liu C., Que Y., Xia N.,
RA   Zhu H., Cheng T.;
RT   "Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its
RT   trans-Golgi network localization.";
RL   Virol. Sin. 32:387-395(2017).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes (PubMed:28356523).
CC       Localizes its binding partner ORF53 to the host trans-Golgi network
CC       (TGN) (PubMed:29116592). {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000269|PubMed:28356523, ECO:0000269|PubMed:29116592}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with ORF53; this interaction mediates
CC       ORF53 localization to the host trans-Golgi network (TGN) and subsequent
CC       incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000250|UniProtKB:P16823, ECO:0000269|PubMed:29116592}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:28356523}. Virion
CC       tegument {ECO:0000250|UniProtKB:P10235}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000269|PubMed:29116592}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57625.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57696.1; -; Genomic_DNA.
DR   RefSeq; NP_040130.1; NC_001348.1.
DR   SMR; Q4JQW8; -.
DR   IntAct; Q4JQW8; 2.
DR   GeneID; 1487677; -.
DR   KEGG; vg:1487677; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007625; Herpes_UL51.
DR   Pfam; PF04540; Herpes_UL51; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Virion; Virion tegument.
FT   CHAIN           1..259
FT                   /note="Tegument protein UL51 homolog"
FT                   /id="PRO_0000385158"
FT   LIPID           9
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   259 AA;  28246 MW;  B35A744D0217D285 CRC64;
     MQTVCASLCG YARIPTEEPS YEEVRVNTHP QGAALLRLQE ALTAVNGLLP APLTLEDVVA
     SADNTRRLVR AQALARTYAA CSRNIECLKQ HHFTEDNPGL NAVVRSHMEN SKRLADMCLA
     AITHLYLSVG AVDVTTDDIV DQTLRMTAES EVVMSDVVLL EKTLGVVAKP QASFDVSHNH
     ELSIAKGENV GLKTSPIKSE ATQLSEIKPP LIEVSDNNTS NLTKKTYPTE TLQPVLTPKQ
     TQDVQRTTPA IKKSHVMLV