ID   TCYP_BACLD              Reviewed;         461 AA.
AC   Q65M31; Q62XG8;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=L-cystine uptake protein TcyP;
DE   AltName: Full=Transporter of cystine TcyP;
GN   Name=tcyP; Synonyms=yhcL; OrderedLocusNames=BLi00975, BL03177;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- FUNCTION: Mediates uptake of L-cystine, the oxidized form of L-
CC       cysteine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AE017333; AAU39883.1; -; Genomic_DNA.
DR   EMBL; CP000002; AAU22540.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q65M31; -.
DR   SMR; Q65M31; -.
DR   STRING; 279010.BL03177; -.
DR   EnsemblBacteria; AAU22540; AAU22540; BL03177.
DR   KEGG; bld:BLi00975; -.
DR   KEGG; bli:BL03177; -.
DR   eggNOG; COG1823; Bacteria.
DR   HOGENOM; CLU_019375_0_1_9; -.
DR   OMA; YFCTTII; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..461
FT                   /note="L-cystine uptake protein TcyP"
FT                   /id="PRO_0000279740"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  48892 MW;  B245D3A450A0A610 CRC64;
     MTLFVVINII VMLGLMALLY MMQKKHVSFS KRVFTALGIG IVFGFALHFI YGSSSETITQ
     TSDWFNIAGG GYVKLLQMIV MPLVFISILG AFTKLKLTHN IGKISGLIIG LLIATTAVAA
     AVGIASALAF DLQAVHVDQG QAETMRGAEL EQKSQDMEAK TLPQQIVELL PGNPFLDFTG
     ARPTSTIAVV IFAAFLGIAY LGVNRKQPEQ AELFKKMVDA VYAIIMRVVT LILRLTPYGV
     LAIMTKTIAT SDLDSIAKLG KFVIASYAAL IVMFIIHLLL ITFSGLNPVT YLKKAFPVLV
     FAFTSRSSAG ALPLNIKTQR SLGVPEGIAN FAGSFGLSIG QNGCAGIYPA MLAIMIAPTV
     GQNPLDPSFL FTVIAVVAIS SFGVAGVGGG ATFAALLVLS ALNMPVALAG LLISVEPLID
     MGRTALNVSG SMTSGLVTSK VTNELEKDTY QDRTNIIEAE V