ID   TCYP_BACHK              Reviewed;         464 AA.
AC   Q6HDR9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=L-cystine uptake protein TcyP;
DE   AltName: Full=Transporter of cystine TcyP;
GN   OrderedLocusNames=BT9727_3988;
OS   Bacillus thuringiensis subsp. konkukian (strain 97-27).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=281309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=97-27;
RX   PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA   Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA   Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA   Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA   Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA   Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA   Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA   Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- FUNCTION: Mediates uptake of L-cystine, the oxidized form of L-
CC       cysteine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AE017355; AAT60793.1; -; Genomic_DNA.
DR   RefSeq; WP_001094341.1; NC_005957.1.
DR   RefSeq; YP_038307.1; NC_005957.1.
DR   AlphaFoldDB; Q6HDR9; -.
DR   SMR; Q6HDR9; -.
DR   EnsemblBacteria; AAT60793; AAT60793; BT9727_3988.
DR   KEGG; btk:BT9727_3988; -.
DR   PATRIC; fig|281309.8.peg.4253; -.
DR   HOGENOM; CLU_019375_0_1_9; -.
DR   OMA; YFCTTII; -.
DR   Proteomes; UP000001301; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..464
FT                   /note="L-cystine uptake protein TcyP"
FT                   /id="PRO_0000279742"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  49242 MW;  2A5B85FA204440C1 CRC64;
     MNTLLVGINV AVMLILVGVL YYMQRKHVSF NKRVFTALGV GIIFGLILQF IYEPTSKVII
     ESNTWFGLIG SGYVKLLQMI VMPLILVSII SAFTKLQLTK NLGKISGLII GILILTTGIA
     AAVGIAASAG FDVSATGLQQ GDAESARLKL VEERFTSIEK TTIPDKLLEL LPTNPFLDLT
     GARPTSTISV VIFAAFIGIA FIGVKRKYPE QAELFKKMLD AVYAIVMRMV TLILRLTPYG
     VLALMAKTVA GSDINAILKL GNFVLASYVA LIVMFVIHLL LIALSGLNPI QYLKKVFPVL
     TFAFTSRSSA GAMPLNIEAQ KEKLGISEGI ANFAASFGVS IGQNGCAGIY PAMLAMMVAP
     TVGIDPLQPQ FILTLIAVVA ISSFGVAGVG GGATFAALIV LSTMNLPIGI VALVISVEPL
     IDMGRTALNV SGSMTAGLIS SKWLGELDQD TYNQDDTKTG EIAS