ID   TCYP_BACCR              Reviewed;         464 AA.
AC   Q818K7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=L-cystine uptake protein TcyP;
DE   AltName: Full=Transporter of cystine TcyP;
GN   OrderedLocusNames=BC_4242;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
CC   -!- FUNCTION: Mediates uptake of L-cystine, the oxidized form of L-
CC       cysteine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016877; AAP11157.1; -; Genomic_DNA.
DR   RefSeq; NP_833956.1; NC_004722.1.
DR   RefSeq; WP_001094344.1; NZ_CP034551.1.
DR   AlphaFoldDB; Q818K7; -.
DR   SMR; Q818K7; -.
DR   STRING; 226900.BC_4242; -.
DR   EnsemblBacteria; AAP11157; AAP11157; BC_4242.
DR   GeneID; 67468547; -.
DR   KEGG; bce:BC4242; -.
DR   PATRIC; fig|226900.8.peg.4386; -.
DR   HOGENOM; CLU_019375_0_1_9; -.
DR   OMA; YFCTTII; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015184; F:L-cystine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="L-cystine uptake protein TcyP"
FT                   /id="PRO_0000279737"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  49283 MW;  7B9ED4F6224EA6A6 CRC64;
     MNTLLVGINV AVMLILVGVL YYMQRKHVSF NKRVFTALGV GILFGLILQF IYEPTSKVII
     ESNTWFGLIG NGYVKLLQMI VMPLILVSII SAFTKLQLTK NLGKISGLII GILILTTGIA
     AAVGIAASAG FDVSATGLQQ GDAESARLKL VEERFTSIEK TTIPDKLLEL LPTNPFLDLT
     GARPTSTISV VIFAAFIGIA FIGVKRKYPE QAELFKKMLD AVYAIVMRMV TLILRLTPYG
     VLALMAKTVA GSDINAILKL GNFVLASYVA LIVMFIIHLL LIALSGLNPI QYLKKVFPVL
     TFAFTSRSSA GAMPLNIEAQ KEKLGISEGI ANFAASFGVS IGQNGCAGIY PAMLAMMVAP
     TVGIDPLQPQ FILTLIAVVA ISSFGVAGVG GGATFAALIV LSTMNLPIGI VALVISVEPL
     IDMGRTALNV SGSMTAGLIS SKWLGELDQD TYNQDDTKTG EIAS