TCYP_BACAN
ID TCYP_BACAN Reviewed; 464 AA.
AC Q81LY8; Q6HTE1; Q6KMN3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=L-cystine uptake protein TcyP;
DE AltName: Full=Transporter of cystine TcyP;
GN OrderedLocusNames=BA_4469, GBAA_4469, BAS4148;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates uptake of L-cystine, the oxidized form of L-
CC cysteine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR EMBL; AE016879; AAP28181.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT33587.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT56448.1; -; Genomic_DNA.
DR RefSeq; NP_846695.1; NC_003997.3.
DR RefSeq; WP_001094329.1; NZ_WXXJ01000027.1.
DR RefSeq; YP_030397.1; NC_005945.1.
DR AlphaFoldDB; Q81LY8; -.
DR SMR; Q81LY8; -.
DR IntAct; Q81LY8; 1.
DR STRING; 260799.BAS4148; -.
DR DNASU; 1087914; -.
DR EnsemblBacteria; AAP28181; AAP28181; BA_4469.
DR EnsemblBacteria; AAT33587; AAT33587; GBAA_4469.
DR GeneID; 45024125; -.
DR KEGG; ban:BA_4469; -.
DR KEGG; bar:GBAA_4469; -.
DR KEGG; bat:BAS4148; -.
DR PATRIC; fig|198094.11.peg.4438; -.
DR eggNOG; COG1823; Bacteria.
DR HOGENOM; CLU_019375_0_1_9; -.
DR OMA; YFCTTII; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3860.10; -; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..464
FT /note="L-cystine uptake protein TcyP"
FT /id="PRO_0000279735"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 49256 MW; 6B784976A4D13A59 CRC64;
MNTLLVGINV AVMLILVGVL YYMQRKHVSF NKRVFTALGI GIIFGLILQF IYEPTSKVII
ESNTWFGLIG SGYVKLLQMI VMPLILVSII SAFTKLQLTK NLGKISGLII GILILTTGIA
AAVGIAASAG FDVSATGLQQ GDAESARLKL VEERFTSIEK TTIPDKLLEL LPTNPFLDLT
GARPTSTISV VIFAAFIGIA FIGVKRKYPE QAELFKKMLD AVYAIVMRMV TLILRLTPYG
VLALMAKTVA GSDINAILKL GNFVLASYVA LIVMFVIHLL LIALSGLNPI QYLKKVFPVL
TFAFTSRSSA GAMPLNIEAQ KEKLGISEGI ANFAASFGVS IGQNGCAGIY PAMLAMMVAP
TVGIDPLQPQ FILTLIAVVA ISSFGVAGVG GGATFAALIV LSTMNLPIGI VALVISVEPL
IDMGRTALNV SGSMTAGLIS SKWLGELDQD TYNQDDTKTG EIAS
