TCYP_ALKCK
ID TCYP_ALKCK Reviewed; 465 AA.
AC Q5WDX9;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=L-cystine uptake protein TcyP;
DE AltName: Full=Transporter of cystine TcyP;
GN OrderedLocusNames=ABC2897;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates uptake of L-cystine, the oxidized form of L-
CC cysteine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR EMBL; AP006627; BAD65431.1; -; Genomic_DNA.
DR RefSeq; WP_011247739.1; NC_006582.1.
DR AlphaFoldDB; Q5WDX9; -.
DR SMR; Q5WDX9; -.
DR STRING; 66692.ABC2897; -.
DR EnsemblBacteria; BAD65431; BAD65431; ABC2897.
DR KEGG; bcl:ABC2897; -.
DR eggNOG; COG1823; Bacteria.
DR HOGENOM; CLU_019375_0_1_9; -.
DR OMA; YFCTTII; -.
DR OrthoDB; 781228at2; -.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3860.10; -; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..465
FT /note="L-cystine uptake protein TcyP"
FT /id="PRO_0000279739"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 465 AA; 48930 MW; CDD4A8F64954FD53 CRC64;
MDLFLTLLII AIVLAVAGLL FYMQKKHVSF SIRVLLALGA GVVYGLLLQF FFAPDSSVIQ
QSMDWVNILG TGYVRFLQMI VMPLIFISIL SAFTRMTLTK NLGKISALIL GTLIATTAIA
AAIGITASSV FQLEAIDIPA GEAELSHGDA LEESYAGMEA ATLPQQIVEL IPANPFLDLT
GERPTSAIGV VIFSAFLGVA YLGVRRKQPE AADTFKGIVN ALYAIIMRVV TLILRLTPYG
VLAIMTRTVA TSDLQAISTL GTFVLASYAA LIVMFVIHLI ILAATGLSPI TYVKKAFPVL
AFAFTSRTSA GALPMNIQTQ KKLGVPEGIA NFAGSFGLSI GQNGCAGIYP AMLAVMIAPT
VGQNPLEPTF ILLLIVVIAI SSFGVAGVGG GATFAAILVL SALDFPIALA GLLISIEPLI
DMGRTALNVS GSMVSGIFTS KVTGSLDKEV FSDPNEQLDT QDMQG
