TCYL_SHIFL
ID TCYL_SHIFL Reviewed; 222 AA.
AC P0AFT4; O07985; P76315;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=L-cystine transport system permease protein TcyL {ECO:0000250|UniProtKB:P0AFT2};
GN Name=tcyL {ECO:0000250|UniProtKB:P0AFT2}; Synonyms=yecS;
GN OrderedLocusNames=SF1961, S2057;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the ABC transporter complex TcyJLN involved in L-
CC cystine import. Responsible for the translocation of the substrate
CC across the membrane. {ECO:0000250|UniProtKB:P0AFT2}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (TcyN),
CC two transmembrane proteins (TcyL) and a solute-binding protein (TcyJ).
CC {ECO:0000250|UniProtKB:P0AFT2}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AFT2}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. HisMQ subfamily. {ECO:0000305}.
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DR EMBL; AE005674; AAN43512.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17342.1; -; Genomic_DNA.
DR RefSeq; NP_707805.1; NC_004337.2.
DR RefSeq; WP_001158220.1; NZ_WPGW01000033.1.
DR AlphaFoldDB; P0AFT4; -.
DR SMR; P0AFT4; -.
DR STRING; 198214.SF1961; -.
DR EnsemblBacteria; AAN43512; AAN43512; SF1961.
DR EnsemblBacteria; AAP17342; AAP17342; S2057.
DR GeneID; 1025176; -.
DR GeneID; 66674192; -.
DR KEGG; sfl:SF1961; -.
DR KEGG; sfx:S2057; -.
DR PATRIC; fig|198214.7.peg.2341; -.
DR HOGENOM; CLU_019602_1_4_6; -.
DR OMA; QWEAGYS; -.
DR OrthoDB; 1523519at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR010065; AA_ABC_transptr_permease_3TM.
DR InterPro; IPR043429; ArtM/GltK/GlnP/TcyL/YhdX-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30614; PTHR30614; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR01726; HEQRo_perm_3TM; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..222
FT /note="L-cystine transport system permease protein TcyL"
FT /id="PRO_0000060252"
FT TOPO_DOM 1..22
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..182
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 19..207
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 222 AA; 24801 MW; F926C4E00C5145D5 CRC64;
MQESIQLVID SLPFLLKGAG YTLQLSIGGM FFGLLLGFIL ALMRLSPIWP VRWLARFYIS
IFRGTPLIAQ LFMIYYGLPQ FGIELDPIPS AMIGLSLNTA AYAAETLRAA ISSIDKGQWE
AAASIGMTPW QTMRRAILPQ AARVALPPLS NSFISLVKDT SLAATIQVPE LFRQAQLITS
RTLEVFTMYL AASLIYWIMA TVLSTLQNHF ENQLNRQERE PK
