ID   TB22B_MACFA             Reviewed;         505 AA.
AC   Q95LL3;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=TBC1 domain family member 22B;
GN   Name=TBC1D22B; ORFNames=QtsA-20424;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE,
CC       YWHAG, YWHAH, YWHAQ and YWHAZ. {ECO:0000250|UniProtKB:Q9NU19}.
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DR   EMBL; AB072775; BAB69744.1; -; mRNA.
DR   RefSeq; NP_001306535.1; NM_001319606.1.
DR   AlphaFoldDB; Q95LL3; -.
DR   SMR; Q95LL3; -.
DR   STRING; 9541.XP_005553185.1; -.
DR   GeneID; 102126123; -.
DR   CTD; 55633; -.
DR   eggNOG; KOG1092; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; GTPase activation; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NU19"
FT   CHAIN           2..505
FT                   /note="TBC1 domain family member 22B"
FT                   /id="PRO_0000208055"
FT   DOMAIN          210..434
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          105..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NU19"
FT   MOD_RES         58
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NU19"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NU19"
FT   MOD_RES         154
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NU19"
SQ   SEQUENCE   505 AA;  59005 MW;  4C74983AD55CBC33 CRC64;
     MAADNSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVGTVP LKNKKASSFH
     EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV LENHSKLRVK PERSQSTTSD
     VPANYKVIKS SSDAQLSRNS SDTCLRNPLH KQQSLPLRPI IPLVARISDQ NASGAPPMTV
     REKTRLEKFR QLLSSHNTDL DELRKCSWPG VPREVRPVTW RLLSGYLPAN TERRKLTLQR
     KREEYFGFIE QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI
     RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD SFWCMSKLLD
     GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV EYLQFAFRWM NNLLMRELPL
     RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE
     EIGLLLAEAY RLKYMFADAP NHYRR