ID   T150A_XENLA             Reviewed;         271 AA.
AC   Q6GPL4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Transmembrane protein 150A;
DE   AltName: Full=Transmembrane protein 150;
GN   Name=tmem150a; Synonyms=tmem150;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates localization of phosphatidylinositol 4-kinase
CC       (PI4K) to the plasma membrane. {ECO:0000250|UniProtKB:Q86TG1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86TG1};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86TG1}.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR   EMBL; BC073101; AAH73101.1; -; mRNA.
DR   RefSeq; NP_001085656.1; NM_001092187.1.
DR   AlphaFoldDB; Q6GPL4; -.
DR   DNASU; 444082; -.
DR   GeneID; 444082; -.
DR   KEGG; xla:444082; -.
DR   CTD; 444082; -.
DR   Xenbase; XB-GENE-866465; tmem150a.L.
DR   OMA; CWINTNA; -.
DR   OrthoDB; 955528at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444082; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR027315; TMEM150A.
DR   PANTHER; PTHR21324:SF6; PTHR21324:SF6; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Transmembrane protein 150A"
FT                   /id="PRO_0000274778"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..108
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..140
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..205
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q86TG1"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  29404 MW;  4CEFD965A6DA8708 CRC64;
     MTGWIVLPIS LTAFSIPGIW IVYAMAVMNH HVCPVENWTY NLTCTDDNTK AGTPKSCCTL
     EDVPLISKCG TYPPESCLFS LIGNVGAFMV VIICLLRYSQ VIEISQRSWL NTTALIAGCT
     NAAGLVMVGN FQVDYAKSLH YIGAGVAFPA GLLFVCLSSI LSYQLAASAL DYWLGHLRVS
     LTIVALISLV LTGVFFIQES FLMQHLVAIC EWIFVLDILV FYGTFAYEFG SVSTDTMMAA
     LQSSAARSCK SPGSSSTSTQ LHCNAERIAM I