ID   T126A_BOVIN             Reviewed;         197 AA.
AC   Q32L86;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transmembrane protein 126A;
GN   Name=TMEM126A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM126 family. {ECO:0000305}.
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DR   EMBL; BC109704; AAI09705.1; -; mRNA.
DR   RefSeq; NP_001032697.1; NM_001037608.2.
DR   AlphaFoldDB; Q32L86; -.
DR   STRING; 9913.ENSBTAP00000000576; -.
DR   PaxDb; Q32L86; -.
DR   Ensembl; ENSBTAT00000000576; ENSBTAP00000000576; ENSBTAG00000000451.
DR   GeneID; 529762; -.
DR   KEGG; bta:529762; -.
DR   CTD; 84233; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000451; -.
DR   VGNC; VGNC:97318; TMEM126A.
DR   eggNOG; ENOG502RYF0; Eukaryota.
DR   GeneTree; ENSGT00520000055616; -.
DR   HOGENOM; CLU_105475_1_0_1; -.
DR   InParanoid; Q32L86; -.
DR   OMA; KMLFPIM; -.
DR   OrthoDB; 1250876at2759; -.
DR   TreeFam; TF327069; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000000451; Expressed in tongue muscle and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR   GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR   InterPro; IPR009801; TMEM126.
DR   PANTHER; PTHR16296; PTHR16296; 1.
DR   Pfam; PF07114; TMEM126; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..197
FT                   /note="Transmembrane protein 126A"
FT                   /id="PRO_0000270998"
FT   TOPO_DOM        1..35
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..58
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..107
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..160
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..197
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   197 AA;  21536 MW;  C8DC31D4516F0DE4 CRC64;
     MENHEPDGTI IKENLTDIIA RKINQLPEAE RNLLENGSTY VGLNAALCGL IANSLFRRIL
     HVTQARIAAG LPMAVIPFLT ANVSYKGFVS LPLNTGDLQC ETCTVTRGGL VGLVFGGLYP
     VFLAIPVNGG LAARYNSALL PEKGNILNYW IRISKPVFRK MLFPILLQTG FAAYLGSRQY
     KLLIKALQLP EPGLEIE