SWET1_RAT
ID SWET1_RAT Reviewed; 221 AA.
AC D3ZH22;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Sugar transporter SWEET1;
DE AltName: Full=RAG1-activating protein 1;
DE AltName: Full=Solute carrier family 50 member 1;
GN Name=Slc50a1; Synonyms=Rag1ap1, Rga;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH TRPV2, AND SUBCELLULAR LOCATION.
RX PubMed=14991772; DOI=10.1002/jcb.10775;
RA Barnhill J.C., Stokes A.J., Koblan-Huberson M., Shimoda L.M., Muraguchi A.,
RA Adra C.N., Turner H.;
RT "RGA protein associates with a TRPV ion channel during biosynthesis and
RT trafficking.";
RL J. Cell. Biochem. 91:808-820(2004).
CC -!- FUNCTION: Mediates sugar transport across membranes. May stimulate
CC V(D)J recombination by the activation of RAG1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TRPV2; the interaction probably occurs
CC intracellularly and depends on TRPV2 N-glycosylation.
CC {ECO:0000269|PubMed:14991772}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:14991772}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14991772}. Cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=May also localize to the
CC endoplasmic reticulum.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH473976; EDM00646.1; -; Genomic_DNA.
DR RefSeq; NP_001099915.1; NM_001106445.1.
DR AlphaFoldDB; D3ZH22; -.
DR SMR; D3ZH22; -.
DR STRING; 10116.ENSRNOP00000027878; -.
DR PaxDb; D3ZH22; -.
DR PeptideAtlas; D3ZH22; -.
DR GeneID; 295245; -.
DR KEGG; rno:295245; -.
DR UCSC; RGD:1308478; rat.
DR CTD; 55974; -.
DR RGD; 1308478; Slc50a1.
DR VEuPathDB; HostDB:ENSRNOG00000020554; -.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_3_0_1; -.
DR InParanoid; D3ZH22; -.
DR OMA; QLNDYYI; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; D3ZH22; -.
DR TreeFam; TF313635; -.
DR Reactome; R-RNO-189200; Cellular hexose transport.
DR PRO; PR:D3ZH22; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Proteomes; UP000234681; Chromosome 2.
DR Bgee; ENSRNOG00000020554; Expressed in colon and 20 other tissues.
DR Genevisible; D3ZH22; RN.
DR GO; GO:0012505; C:endomembrane system; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0042947; F:glucoside transmembrane transporter activity; ISO:RGD.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..221
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000405430"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 10..94
FT /note="MtN3/slv 1"
FT DOMAIN 127..212
FT /note="MtN3/slv 2"
FT REGION 149..221
FT /note="Mediates interaction with TRPV2"
FT /evidence="ECO:0000269|PubMed:14991772"
SQ SEQUENCE 221 AA; 24694 MW; 53B7483FBDA003E5 CRC64;
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT DVNNLGWLSY
GVLKGDGTLI IVNTVGAVLQ TLYILAYLHY SPQKHAVLLQ TATLLAVLLL GYGYFWLLVP
DLETRLQQLG LFCSVFTISM YLSPLADLAK IIQTKSTQRL SFSLTIATLL SSTSWSIYGF
RLKDPYITVP NLPGILTGFI RLVLFYKYPP EQDTKYRLLQ T
