SWC3_SCHPO
ID SWC3_SCHPO Reviewed; 391 AA.
AC Q10210;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=SWR1 complex subunit swc3;
GN Name=swc3; ORFNames=SPAC4H3.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP IDENTIFICATION IN THE SWR1 COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=19040720; DOI=10.1186/gb-2008-9-11-r167;
RA Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C.,
RA Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.;
RT "Chromatin Central: towards the comparative proteome by accurate mapping of
RT the yeast proteomic environment.";
RL Genome Biol. 9:R167.1-R167.22(2008).
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant H2A.Z leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex.
CC {ECO:0000269|PubMed:19040720}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the SWC3 family. {ECO:0000305}.
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DR EMBL; CU329670; CAA93341.1; -; Genomic_DNA.
DR PIR; T38882; T38882.
DR RefSeq; NP_594338.1; NM_001019759.2.
DR AlphaFoldDB; Q10210; -.
DR SMR; Q10210; -.
DR BioGRID; 280081; 77.
DR STRING; 4896.SPAC4H3.02c.1; -.
DR MaxQB; Q10210; -.
DR PaxDb; Q10210; -.
DR EnsemblFungi; SPAC4H3.02c.1; SPAC4H3.02c.1:pep; SPAC4H3.02c.
DR GeneID; 2543667; -.
DR KEGG; spo:SPAC4H3.02c; -.
DR PomBase; SPAC4H3.02c; swc3.
DR VEuPathDB; FungiDB:SPAC4H3.02c; -.
DR HOGENOM; CLU_702405_0_0_1; -.
DR OMA; CILLHNE; -.
DR PRO; PR:Q10210; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000812; C:Swr1 complex; IDA:PomBase.
DR GO; GO:0006338; P:chromatin remodeling; IPI:PomBase.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IC:PomBase.
DR InterPro; IPR037651; Swc3.
DR PANTHER; PTHR28108; PTHR28108; 2.
PE 1: Evidence at protein level;
KW Chromatin regulator; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..391
FT /note="SWR1 complex subunit swc3"
FT /id="PRO_0000116481"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 44717 MW; 72D8F088B15E50A8 CRC64;
MSLNGTFSHN NGLPSGEREE SETPGGSTSI ISSSFLLQPR ASDSRPDALE GKYDKNVLAR
ALKKSRDSCL NGALFEKFLP EENYKLSGGT VFSHVRYIDT ATLCVGPLRF EDTKFYFVHY
SNSPIEPFAK PNISYVNPQW NELDYRPDSQ KLSPGKEKNT LDLKHCLLPS PEYKAPPAKK
PEDYEASPGE PVEPLITDAS LQRLKSRANE DPTIFNILKR ISKGLGTPEQ CMLLHNELIG
PSTFPLPKRA KKPPRKRITL SINQQDKDEF FDSLINNKKE VRRHFDIVME FSDAPDTKWI
FPRESVLSHV FNTDKKKLEA LSLLFHVYRP TEDRNVIDVK TEIKIRDFTP TLRSAIELLT
SGTHADRLLS EKRRRMSNLE PKYYMQFHEQ T
