ID   STS1_SORMK              Reviewed;         304 AA.
AC   D1ZMW1; F7VZ82;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=SMAC_07846;
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA   Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CABT02000014; CCC10829.1; -; Genomic_DNA.
DR   RefSeq; XP_003346369.1; XM_003346321.1.
DR   AlphaFoldDB; D1ZMW1; -.
DR   SMR; D1ZMW1; -.
DR   STRING; 771870.D1ZMW1; -.
DR   EnsemblFungi; CCC10829; CCC10829; SMAC_07846.
DR   GeneID; 10803760; -.
DR   KEGG; smp:SMAC_07846; -.
DR   VEuPathDB; FungiDB:SMAC_07846; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   InParanoid; D1ZMW1; -.
DR   OMA; SSLGWMH; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..304
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409433"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   304 AA;  33737 MW;  7E73F3BEAD41ECD9 CRC64;
     MNVLLSPQPL FFPHQHEPSR RSPPRTMSHY TMTSRKRKAD DDDNEMSVSP TGSPAINPRQ
     LSRPSKKVRA GIELAGRPLP LPRLLETLDK TQLRAVLQTI CERHPDIGHE VMTSAPRPSV
     NGALEVLGEY QDKLRAAIPF GNSSSEYTYY RVKQPLMALV DALGDFTPQF LPPVEQQTTV
     SLEYLNHATK IIHDLPDFDS QQYRHHKDGA YDEISRAWAL VITEAAKRGG GFHLHNGKWD
     QVLAKHNQQS GGKLEQAMNA MVNEVGWIGA NQNAHGQGSS SDPNSILNQL INGTYGAPVQ
     VGPF