STR1_MEDTR
ID STR1_MEDTR Reviewed; 817 AA.
AC D3GE74;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=ABC transporter G family member STR {ECO:0000303|PubMed:20453115};
DE EC=7.6.2.-;
DE AltName: Full=Protein STUNTED ARBUSCULE {ECO:0000303|PubMed:20453115};
GN Name=STR {ECO:0000303|PubMed:20453115};
GN OrderedLocusNames=MTR_8g107450 {ECO:0000312|EMBL:AET05608.1};
GN ORFNames=MtrunA17_Chr8g0393191 {ECO:0000312|EMBL:RHN43934.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE,
RP TISSUE SPECIFICITY, INDUCTION BY GLOMUS VERSIFORME, INTERACTION WITH STR2,
RP AND SUBCELLULAR LOCATION.
RX PubMed=20453115; DOI=10.1105/tpc.110.074955;
RA Zhang Q., Blaylock L.A., Harrison M.J.;
RT "Two Medicago truncatula half-ABC transporters are essential for arbuscule
RT development in arbuscular mycorrhizal symbiosis.";
RL Plant Cell 22:1483-1497(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17;
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B.,
RA Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H.,
RA Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F.,
RA De Mita S., Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K.,
RA Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H.,
RA Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M.,
RA Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N.,
RA Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M.,
RA Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S.,
RA Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J.,
RA Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H.,
RA Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J.,
RA Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C.,
RA O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F.,
RA Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O.,
RA Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R.,
RA Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B.,
RA Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D.,
RA White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F.,
RA Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D.,
RA Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17;
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17;
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5]
RP INDUCTION BY RAM1 AND GLOMUS VERSIFORME.
RX PubMed=26511916; DOI=10.1104/pp.15.01155;
RA Park H.-J., Floss D.S., Levesque-Tremblay V., Bravo A., Harrison M.J.;
RT "Hyphal branching during arbuscule development requires reduced arbuscular
RT mycorrhiza1.";
RL Plant Physiol. 169:2774-2788(2015).
CC -!- FUNCTION: Together with STR2, required for arbuscule development in
CC arbuscular mycorrhizal (AM) symbiosis. {ECO:0000269|PubMed:20453115}.
CC -!- SUBUNIT: Heterodimerizes with STR2; the resulting transporter is
CC located in the peri-arbuscular membrane. {ECO:0000269|PubMed:20453115}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20453115};
CC Multi-pass membrane protein {ECO:0000255}. Note=Located in the peri-
CC arbuscular membrane of arbuscular mycorrhiza (AM).
CC {ECO:0000269|PubMed:20453115}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in the vascular tissue of
CC roots. {ECO:0000269|PubMed:20453115}.
CC -!- INDUCTION: Accumulates in roots cortical cells containing arbuscules,
CC in a RAM1-dependent manner, upon arbuscular mycorrhizal (AM) symbiosis
CC with Glomus versiforme (PubMed:20453115, PubMed:26511916). Triggered by
CC RAM1 (PubMed:26511916). {ECO:0000269|PubMed:20453115,
CC ECO:0000269|PubMed:26511916}.
CC -!- DISRUPTION PHENOTYPE: Stunted arbuscule phenotype due to an impaired
CC arbuscule development during arbuscular mycorrhizal (AM) symbiosis with
CC Glomus versiforme; normal initial phases of the symbiosis, including
CC hyphopodia formation and fungal entry into the cortex, as well as
CC normal arbuscule development initiation, including arbuscule-associated
CC genes expression, but strongly delayed and impaired arbuscule
CC development (PubMed:20453115). Normal nodulation in the presence of
CC Sinorhizobium meliloti (PubMed:20453115).
CC {ECO:0000269|PubMed:20453115}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Stunted arbuscule (STR) subfamily. {ECO:0000305}.
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DR EMBL; FJ659114; ACV73541.1; -; Genomic_DNA.
DR EMBL; FJ659115; ACV73542.1; -; mRNA.
DR EMBL; CM001224; AET05608.1; -; Genomic_DNA.
DR EMBL; PSQE01000008; RHN43934.1; -; Genomic_DNA.
DR RefSeq; XP_003631132.1; XM_003631084.2.
DR AlphaFoldDB; D3GE74; -.
DR SMR; D3GE74; -.
DR STRING; 3880.AET05608; -.
DR TCDB; 3.A.1.204.22; the atp-binding cassette (abc) superfamily.
DR EnsemblPlants; AET05608; AET05608; MTR_8g107450.
DR GeneID; 11412901; -.
DR Gramene; AET05608; AET05608; MTR_8g107450.
DR KEGG; mtr:MTR_8g107450; -.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR OMA; SVWVYHG; -.
DR OrthoDB; 1022017at2759; -.
DR Proteomes; UP000002051; Chromosome 8.
DR Proteomes; UP000265566; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0085042; C:periarbuscular membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0036377; P:arbuscular mycorrhizal association; IMP:UniProtKB.
DR GO; GO:0009610; P:response to symbiotic fungus; IEP:UniProtKB.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Glycoprotein; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..817
FT /note="ABC transporter G family member STR"
FT /id="PRO_0000450018"
FT TOPO_DOM 1..542
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 543..563
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 564..579
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 580..600
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 601..621
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 622..642
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 643..657
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 658..678
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 679..681
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 682..702
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 703..787
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 788..808
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 809..817
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 43..294
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 87..94
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 762
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 817 AA; 91885 MW; 70B5CE92E5EA19D6 CRC64;
MARLERDGTN KSLESLMDSH KPGGTTTNLN QLRTQKSIPG YGLEFTNLSY SIIKKQKKDG
VWINKETYLL HDISGQAIKG EIMAIMGPSG AGKSTFLDAL AGRIAKGSLQ GSVRIDGKPV
TTSYMKMVSS YVMQDDQLFP MLTVFETFMF AAEVRLPPSI SRDEKKKRVH ELLNKLGLQS
ATHTYIGDEG RRGVSGGERR RVSIGIEIIH KPSLLFLDEP TSGLDSTSAY SVVEKIKDIA
QGGSIVLMTI HQPSFRIQML LDKITILARG RLIYMGRPDA LHTHLSGFGR PVPDGENNIE
YLLDVITEYD QATVGLDPLV QYQHDGHKPD PAAMTPVPKP PRTPYRRNTP ASKHMISLRS
QGFTAGTPQP DSSQFGLDDD DNDDDENFDN SLERRSVQTS RNIVTSGVYP RLASQFYQDF
SAKDFSVWLY NGVVGTPRRP PSWTPARTPG WTPGKTPLSG PRSFVSNQHS ASYQDPYYIQ
KTNTVVGQSM DYSATSYAPS YEEFEIEEVL DEPDLGPKYA NPWLREVAVL SWRTVLNVIR
TPELFASREI VLTVMALVLS TIFKNLGDTT FIDINRLLNF YIFAVCLVFF SSNDAVPSFI
MERFIFIRET SHNAYRASSY VISSLIVYLP FFAVQGLTFA VITKLMLHLK SNLFNFWMIL
FASLITTNAY VMLVSALVPS YITGYAVVIA TTALFFLTCG FFLKRTQIPA YWKWLHYISA
IKYPFEGLLI NEFKNNRGCY SGNKADLSPG PLGDVKPSKH HNASLPLNCL LGEDVLSTMD
ITMESLWYDI LILLAWGVLY RFFFYLVLRF YSKNERK
