ID   STP_BPLZ5               Reviewed;          26 AA.
AC   P62767; P18788;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   12-AUG-2020, entry version 34.
DE   RecName: Full=Anticodon nuclease activator;
GN   Name=stp;
OS   Enterobacteria phage LZ5 (Bacteriophage LZ5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus;
OC   unclassified Tequatrovirus.
OX   NCBI_TaxID=37363;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=7791212; DOI=10.1006/jmbi.1995.0343;
RA   Penner M., Morad I., Snyder L., Kaufmann G.;
RT   "Phage T4-coded Stp: double-edged effector of coupled DNA and tRNA-
RT   restriction systems.";
RL   J. Mol. Biol. 249:857-868(1995).
CC   -!- FUNCTION: Anticodon nuclease cleaves the tRNA(Lys). It cleaves near a
CC       pyrimidine base to generate 2':3'-P> and 5'-OH termini. Stp activates
CC       the host prrC protein probably by counteracting prr masking. Stp also
CC       inhibits EcoprrI restriction. Stp probably alters the conformation of
CC       EcoprrI and, consequently, of prrC, allowing activation of the latent
CC       anticodon nuclease. Presumably, stp evolved to offset a DNA restriction
CC       system of the host cell but was turned, eventually, against the phage
CC       as an activator of the appended tRNA restriction enzyme.
CC       {ECO:0000269|PubMed:7791212}.
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DR   EMBL; Z46876; CAA86956.1; -; Genomic_DNA.
DR   PIR; S55799; S55799.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0050792; P:regulation of viral process; IEA:InterPro.
DR   InterPro; IPR012585; Stp.
DR   Pfam; PF08133; Nuclease_act; 1.
PE   4: Predicted;
KW   Hydrolase; Nuclease.
FT   PEPTIDE         1..26
FT                   /note="Anticodon nuclease activator"
FT                   /id="PRO_0000164987"
SQ   SEQUENCE   26 AA;  3184 MW;  50416719F5088D40 CRC64;
     MSNFHNEHVM QFYRNNLKTK GVFGRQ