STPKL_ARATH
ID STPKL_ARATH Reviewed; 341 AA.
AC Q9FMY3; Q50IB8; Q50IC8; Q50ID4; Q50IE0; Q50IE8; Q50IF7; Q50IG2; Q50IG5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Serine/threonine-protein kinase-like protein At5g23170;
DE EC=2.7.11.1;
GN OrderedLocusNames=At5g23170; ORFNames=MKD15.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Aa-0, cv. Ag-0, cv. Bl-0, cv. Bla-10, cv. Cal-0, cv. Can-0,
RC cv. Cnt-1, cv. Columbia, cv. Cvi-0, cv. Di-0, cv. Di-1, cv. Di-G,
RC cv. Ema-1, cv. Ka-0, cv. Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. Ma-0,
RC cv. Mt-0, cv. No-0, cv. Oy-0, cv. Pa-1, cv. Per-1, cv. Petergof, cv. Pi-0,
RC cv. Sei-0, cv. Sorbo, cv. Su-0, cv. Tac-0, cv. Tsu-0, and cv. Yo-0;
RX PubMed=15875023; DOI=10.1038/nature03480;
RA Kroymann J., Mitchell-Olds T.;
RT "Epistasis and balanced polymorphism influencing complex trait variation.";
RL Nature 435:95-98(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP GENE FAMILY.
RX PubMed=19529822; DOI=10.1093/mp/ssn083;
RA Chae L., Sudat S., Dudoit S., Zhu T., Luan S.;
RT "Diverse transcriptional programs associated with environmental stress and
RT hormones in the Arabidopsis receptor-like kinase gene family.";
RL Mol. Plant 2:84-107(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Higher expression in mature stamina and
CC pollen. {ECO:0000269|PubMed:15875023}.
CC -!- MISCELLANEOUS: This gene is linked with a growth rate QTL (quantitative
CC trait locus).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB007648; BAB11172.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93129.1; -; Genomic_DNA.
DR EMBL; AJ864997; CAI23745.1; -; Genomic_DNA.
DR EMBL; AJ864994; CAI23739.1; -; Genomic_DNA.
DR EMBL; AJ864992; CAI23737.1; -; Genomic_DNA.
DR EMBL; AJ864991; CAI23735.1; -; Genomic_DNA.
DR EMBL; AJ864983; CAI23717.1; -; Genomic_DNA.
DR EMBL; AJ864976; CAI23703.1; -; Genomic_DNA.
DR EMBL; AJ864969; CAI23691.1; -; Genomic_DNA.
DR EMBL; AJ864968; CAI23689.1; -; Genomic_DNA.
DR EMBL; AJ864980; CAI23711.1; -; Genomic_DNA.
DR EMBL; AJ864984; CAI23720.1; -; Genomic_DNA.
DR EMBL; AJ864973; CAI23697.1; -; Genomic_DNA.
DR EMBL; AJ864996; CAI23743.1; -; Genomic_DNA.
DR EMBL; AJ864972; CAI23695.1; -; Genomic_DNA.
DR EMBL; AJ864990; CAI23733.1; -; Genomic_DNA.
DR EMBL; AJ864971; CAI23693.1; -; Genomic_DNA.
DR EMBL; AJ864989; CAI23731.1; -; Genomic_DNA.
DR EMBL; AJ864985; CAI23723.1; -; Genomic_DNA.
DR EMBL; AJ864982; CAI23715.1; -; Genomic_DNA.
DR EMBL; AJ864981; CAI23713.1; -; Genomic_DNA.
DR EMBL; AJ864970; CAI23749.1; -; Genomic_DNA.
DR EMBL; AJ864987; CAI23727.1; -; Genomic_DNA.
DR EMBL; AJ864995; CAI23741.1; -; Genomic_DNA.
DR EMBL; AJ864979; CAI23709.1; -; Genomic_DNA.
DR EMBL; AJ864975; CAI23701.1; -; Genomic_DNA.
DR EMBL; AJ864998; CAI23747.1; -; Genomic_DNA.
DR EMBL; AJ864993; CAI23751.1; -; Genomic_DNA.
DR EMBL; AJ864988; CAI23729.1; -; Genomic_DNA.
DR EMBL; AJ864986; CAI23725.1; -; Genomic_DNA.
DR EMBL; AJ864978; CAI23707.1; -; Genomic_DNA.
DR EMBL; AJ864977; CAI23705.1; -; Genomic_DNA.
DR EMBL; AJ864974; CAI23699.1; -; Genomic_DNA.
DR EMBL; BT005316; AAO63380.1; -; mRNA.
DR EMBL; AK117152; BAC41830.1; -; mRNA.
DR RefSeq; NP_197708.1; NM_122223.4.
DR AlphaFoldDB; Q9FMY3; -.
DR SMR; Q9FMY3; -.
DR BioGRID; 17656; 1.
DR IntAct; Q9FMY3; 1.
DR STRING; 3702.AT5G23170.1; -.
DR PaxDb; Q9FMY3; -.
DR PRIDE; Q9FMY3; -.
DR EnsemblPlants; AT5G23170.1; AT5G23170.1; AT5G23170.
DR GeneID; 832381; -.
DR Gramene; AT5G23170.1; AT5G23170.1; AT5G23170.
DR KEGG; ath:AT5G23170; -.
DR Araport; AT5G23170; -.
DR TAIR; locus:2166761; AT5G23170.
DR eggNOG; KOG1187; Eukaryota.
DR HOGENOM; CLU_000288_21_4_1; -.
DR InParanoid; Q9FMY3; -.
DR OMA; KIGEICC; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; Q9FMY3; -.
DR PRO; PR:Q9FMY3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMY3; baseline and differential.
DR Genevisible; Q9FMY3; AT.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045271; SRF-like.
DR PANTHER; PTHR27001; PTHR27001; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..341
FT /note="Serine/threonine-protein kinase-like protein
FT At5g23170"
FT /id="PRO_0000271405"
FT DOMAIN 16..298
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 52..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 311..332
FT /evidence="ECO:0000255"
FT COMPBIAS 52..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 22..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VARIANT 40
FT /note="V -> D (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Pa-1,
FT cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-
FT 0)"
FT VARIANT 45
FT /note="Q -> R (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Pa-1,
FT cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-
FT 0)"
FT VARIANT 54
FT /note="S -> SSL (in strain: cv. Per-1, cv. Su-0 and cv. Yo-
FT 0)"
FT VARIANT 56
FT /note="L -> LSLSPS (in strain: cv. Bla-10, cv. Bl-0, cv.
FT Can-0, cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0,
FT cv. Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv.
FT Pa-1, cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv.
FT Tsu-0)"
FT VARIANT 80
FT /note="D -> N (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Pa-1,
FT cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-
FT 0)"
FT VARIANT 104
FT /note="V -> I (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Pa-1,
FT cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-
FT 0)"
FT VARIANT 111
FT /note="E -> G (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Pa-1,
FT cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-
FT 0)"
FT VARIANT 114
FT /note="Y -> H (in strain: cv. Bla-10, cv. Bl-0, cv. Cal-0,
FT cv. Can-0, cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Di-1, cv.
FT Ema-1, cv. Ka-0, cv. Kas-1, cv. Landsberg erecta, cv. Lip-
FT 0, cv. No-0, cv. Pa-1, cv. Per-1, cv. Petergof, cv. Sei-0,
FT cv. Sorbo, cv. Su-0, cv. Tac-0, cv. Tsu-0 and cv. Yo-0)"
FT VARIANT 126
FT /note="T -> A (in strain: cv. Di-1)"
FT VARIANT 142
FT /note="H -> N (in strain: cv. Bl-0, cv. Cnt-1, cv. Ema-1,
FT cv. Ka-0, cv. Kas-1, cv. No-0, cv. Sei-0 and cv. Tac-0)"
FT VARIANT 147..149
FT /note="HGI -> QGV (in strain: cv. Bla-10, cv. Bl-0, cv.
FT Can-0, cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0,
FT cv. Kas-1, cv. Landsberg erecta, cv. No-0, cv. Pa-1, cv.
FT Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-0)"
FT VARIANT 177
FT /note="D -> E (in strain: cv. Bla-10, cv. Bl-0, cv. Can-0,
FT cv. Cnt-1, cv. Cvi-0, cv. Di-G, cv. Ema-1, cv. Ka-0, cv.
FT Kas-1, cv. Landsberg erecta, cv. No-0, cv. Pa-1, cv.
FT Petergof, cv. Sei-0, cv. Sorbo, cv. Tac-0 and cv. Tsu-0)"
FT VARIANT 237
FT /note="I -> M (in strain: cv. Sorbo)"
FT VARIANT 255
FT /note="Missing (in strain: cv. Bla-10, cv. Bl-0, cv. Cnt-1,
FT cv. Ema-1, cv. Ka-0, cv. Kas-1, cv. No-0, cv. Pa-1, cv.
FT Sei-0 and cv. Tac-0)"
FT VARIANT 269
FT /note="L -> Q (in strain: cv. Bla-10, cv. Bl-0, cv. Cnt-1,
FT cv. Ema-1, cv. Ka-0, cv. Kas-1, cv. No-0, cv. Pa-1, cv.
FT Sei-0 and cv. Tac-0)"
FT VARIANT 297
FT /note="V -> M (in strain: cv. Can-0, cv. Cvi-0, cv. Di-G,
FT cv. Landsberg erecta, cv. Lip-0, cv. Petergof, cv. Sorbo
FT and cv. Tsu-0)"
FT VARIANT 301
FT /note="A -> E (in strain: cv. Can-0, cv. Cvi-0, cv. Di-G,
FT cv. Landsberg erecta, cv. Lip-0, cv. Petergof, cv. Sorbo
FT and cv. Tsu-0)"
SQ SEQUENCE 341 AA; 38003 MW; 7B742E0392C45258 CRC64;
MKEFDYDKLV TAIDRFSPSK LIGKGSHGYV YKALLHHQDV DETRQRVVAI KTPSSLSPSS
PSSSSSSKSE QTKKLENEID VMSSLPYHPH VLSFLGHAEK KLMVVEYMPN ESLYQLLHVS
TDPLPTWLKR IEIALQIASA VHFLHEHGII HRDIKSENIL FDSNWEAKLA DFGLAVDFGG
DKKIRPAPAG TIGYLDPCYT LPENLSMKTD VYSYGVVLLE IVSCRKAIDV SRSPASIVDW
AVPLIKEGRI GEICGGGGGG SGVFRGMSLR LLRMAARCVS SDVESRPCFG EITAEIVACL
AEPLKSLPLW MSVLRRVVKL KRRKKRLRET LTWPGQTCRV W
