STML3_HUMAN
ID STML3_HUMAN Reviewed; 291 AA.
AC Q8TAV4; B4E285; Q5JS35;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Stomatin-like protein 3;
DE Short=SLP-3;
GN Name=STOML3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for the function of many mechanoreceptors. Modulate
CC mechanotransduction channels and acid-sensing ion channels (ASIC)
CC proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their
CC sensitivity to mechanical stimulations. {ECO:0000250|UniProtKB:Q6PE84}.
CC -!- SUBUNIT: Homodimer. Interacts with PIEZO1 and PIEZO2.
CC {ECO:0000250|UniProtKB:Q6PE84}.
CC -!- INTERACTION:
CC Q8TAV4; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-12900395, EBI-10225815;
CC Q8TAV4; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-12900395, EBI-12256978;
CC Q8TAV4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12900395, EBI-10266796;
CC Q8TAV4; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12900395, EBI-8652744;
CC Q8TAV4; O00526: UPK2; NbExp=3; IntAct=EBI-12900395, EBI-10179682;
CC Q8TAV4; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-12900395, EBI-10254561;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PE84};
CC Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q6PE84}.
CC Note=Detected in lipid rafts. {ECO:0000250|UniProtKB:Q6PE84}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAV4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAV4-2; Sequence=VSP_042937;
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000305}.
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DR EMBL; AK304159; BAG65047.1; -; mRNA.
DR EMBL; AL445590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025760; AAH25760.1; -; mRNA.
DR CCDS; CCDS45040.1; -. [Q8TAV4-2]
DR CCDS; CCDS9367.1; -. [Q8TAV4-1]
DR RefSeq; NP_001137505.1; NM_001144033.1. [Q8TAV4-2]
DR RefSeq; NP_660329.1; NM_145286.2. [Q8TAV4-1]
DR AlphaFoldDB; Q8TAV4; -.
DR SMR; Q8TAV4; -.
DR BioGRID; 127771; 8.
DR IntAct; Q8TAV4; 6.
DR STRING; 9606.ENSP00000368952; -.
DR TCDB; 8.A.21.1.3; the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family.
DR iPTMnet; Q8TAV4; -.
DR PhosphoSitePlus; Q8TAV4; -.
DR SwissPalm; Q8TAV4; -.
DR BioMuta; STOML3; -.
DR DMDM; 60415939; -.
DR jPOST; Q8TAV4; -.
DR MassIVE; Q8TAV4; -.
DR MaxQB; Q8TAV4; -.
DR PaxDb; Q8TAV4; -.
DR PeptideAtlas; Q8TAV4; -.
DR PRIDE; Q8TAV4; -.
DR ProteomicsDB; 73928; -. [Q8TAV4-1]
DR ProteomicsDB; 73929; -. [Q8TAV4-2]
DR Antibodypedia; 2442; 105 antibodies from 18 providers.
DR DNASU; 161003; -.
DR Ensembl; ENST00000379631.9; ENSP00000368952.4; ENSG00000133115.12. [Q8TAV4-1]
DR Ensembl; ENST00000423210.1; ENSP00000401989.1; ENSG00000133115.12. [Q8TAV4-2]
DR GeneID; 161003; -.
DR KEGG; hsa:161003; -.
DR MANE-Select; ENST00000379631.9; ENSP00000368952.4; NM_145286.3; NP_660329.1.
DR UCSC; uc001uwx.4; human. [Q8TAV4-1]
DR CTD; 161003; -.
DR DisGeNET; 161003; -.
DR GeneCards; STOML3; -.
DR HGNC; HGNC:19420; STOML3.
DR HPA; ENSG00000133115; Tissue enriched (fallopian).
DR MIM; 608327; gene.
DR neXtProt; NX_Q8TAV4; -.
DR OpenTargets; ENSG00000133115; -.
DR PharmGKB; PA134939552; -.
DR VEuPathDB; HostDB:ENSG00000133115; -.
DR eggNOG; KOG2621; Eukaryota.
DR GeneTree; ENSGT01030000234614; -.
DR HOGENOM; CLU_024949_3_0_1; -.
DR InParanoid; Q8TAV4; -.
DR OMA; MFQVTDP; -.
DR OrthoDB; 1062075at2759; -.
DR PhylomeDB; Q8TAV4; -.
DR TreeFam; TF105750; -.
DR PathwayCommons; Q8TAV4; -.
DR Reactome; R-HSA-2672351; Stimuli-sensing channels.
DR SignaLink; Q8TAV4; -.
DR BioGRID-ORCS; 161003; 12 hits in 1074 CRISPR screens.
DR ChiTaRS; STOML3; human.
DR GenomeRNAi; 161003; -.
DR Pharos; Q8TAV4; Tbio.
DR PRO; PR:Q8TAV4; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8TAV4; protein.
DR Bgee; ENSG00000133115; Expressed in right uterine tube and 40 other tissues.
DR Genevisible; Q8TAV4; HS.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR043202; Band-7_stomatin-like.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR018080; Band_7/stomatin-like_CS.
DR InterPro; IPR028519; SLP3.
DR InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR PANTHER; PTHR10264; PTHR10264; 1.
DR PANTHER; PTHR10264:SF49; PTHR10264:SF49; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00721; STOMATIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
DR PROSITE; PS01270; BAND_7; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Membrane; Phosphoprotein;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..291
FT /note="Stomatin-like protein 3"
FT /id="PRO_0000094033"
FT TRANSMEM 29..49
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P27105"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P27105"
FT VAR_SEQ 1..16
FT /note="MDSRVSSPEKQDKENF -> MNSRGEL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042937"
SQ SEQUENCE 291 AA; 32135 MW; B51A7DD5E96E1935 CRC64;
MDSRVSSPEK QDKENFVGVN NKRLGVCGWI LFSLSFLLVI ITFPISIWMC LKIIKEYERA
VVFRLGRIQA DKAKGPGLIL VLPCIDVFVK VDLRTVTCNI PPQEILTRDS VTTQVDGVVY
YRIYSAVSAV ANVNDVHQAT FLLAQTTLRN VLGTQTLSQI LAGREEIAHS IQTLLDDATE
LWGIRVARVE IKDVRIPVQL QRSMAAEAEA TREARAKVLA AEGEMNASKS LKSASMVLAE
SPIALQLRYL QTLSTVATEK NSTIVFPLPM NILEGIGGVS YDNHKKLPNK A
